Daoyu Zhang
Jilin University
PromoterDrug repositioningMessenger RNAMCF-7Gene silencingCancerDownregulation and upregulationmicroRNAGene expressionMolecular biologyTranscriptomeDNMT1ChemistryApoptosisDNA methylationFADDWestern blotPTENFLNADNA methyltransferaseTriple-negative breast cancerFLNBCell cycleMethylationCancer researchBreast cancerFlow cytometryCompeting endogenous RNAMedicineCell culturePI3K/AKT/mTOR pathwayBiologyCancer cell
4Publications
1H-index
3Citations
Publications 4
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
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Breast cancer is one of the most prevalent and reoccurring cancer types that leads to death in women. Triple-negative breast cancer (TNBC) is difficult to treat due to the lack of therapeutic targets. Many studies have focused on identifying drugs for use as alternative treatments for breast cancer. Thioguanine (6-TG) exerts antitumor effects in cancer. Increasing evidence has demonstrated that ceRNAs are involved in cancer processes. However, the mechanism by which 6-TG regulates lncRNA-miRNA-m...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 10 authors...
Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies. Chemotherapy is the main clinical therapy, but the effective screening strategy for chemotherapy drugs is poorly investigated. Drug repositioning has been the center of attention in recent years attracting numerous studies. Here, we firstly found multiple common features between leukemia and TNBC by analyzing the global transcriptome profile...
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#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Background: 6-thioguanine (6-TG), as a conventional "ancient" drug for the treatment of acute leukemia, has been proved to have extensive anti-tumor roles. This study was created to investigate the hidden function of 6-TG on the MCF-7 breast cancer cell line (ER+, PR+) and its mechanisms. Methods: MCF-7 cells were treated with 6-TG, and the IC50 value was measured by a cell counting kit-8 assay. Differentially expressed genes (DEGs) were confirmed by RNA-seq analysis. Apoptosis and cell cycle co...
2 CitationsSource
#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Sheng Zhang (JLU: Jilin University)H-Index: 9
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: Human leukocyte antigen-G (HLA-G) is highly expressed in numerous solid tumor cell types and has important roles in protecting tumor cells from host immune recognition and destruction. DNA methylation modification, which may regulate gene expression, is aberrant in numerous tumor cell types. However, whether the high expression of HLA-G in tumor cells is induced by aberrant DNA methylation has remained elusive. In the present study, HLA-G, DNA methyltransferase (DNMT) and ten-eleven translocat...
1 CitationsSource