Yan Cai
Southeast University
Endothelial stem cellInternal medicineMicrocirculationCell migrationPathologyPerfusionCellBlood flowHemodynamicsChemistryExtracellular matrixMicrovesselVascular endothelial growth factorNeovascularizationAngiogenesisTumor angiogenesisAnti angiogenicCancer researchMedicineEndostatinBiologyCell biology
42Publications
8H-index
236Citations
Publications 38
Newest
#1Jichao Pan (SEU: Southeast University)H-Index: 1
#2Yan Cai (SEU: Southeast University)H-Index: 8
Last. Zhiyong Li (QUT: Queensland University of Technology)H-Index: 29
view all 4 authors...
Growing genetic lineage mapping experiments have definitively shown a wide-ranging plasticity of vascular smooth muscle cells (VSMCs) in atherosclerotic plaque and suggested that VSMCs can modulate their phenotypes in response to plaque microenvironment. Here, a multiscale hybrid discrete-continuous (HDC) modeling system is established to investigate the complex role of VSMC phenotypic switching within atherosclerotic lesions. The cellular behaviors of VSMCs and macrophages, including proliferat...
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#1Jie Wu (SJTU: Shanghai Jiao Tong University)H-Index: 9
#2Yan Cai (SEU: Southeast University)H-Index: 8
Last. Maolan LiH-Index: 29
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Background Patients with triple-negative breast cancer (TNBC) face a major challenge of the poor prognosis, and N6-methyladenosine-(m6A) mediated regulation in cancer has been proposed. Therefore, this study aimed to explore the prognostic roles of m6A-related long non-coding RNAs (LncRNAs) in TNBC. Methods Clinical information and expression data of TNBC samples were collected from TCGA and GEO databases. Pearson correlation, univariate, and multivariate Cox regression analysis were employed to...
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#1Yan Cai (SEU: Southeast University)H-Index: 8
#2Jichao Pan (SEU: Southeast University)H-Index: 1
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
view all 3 authors...
BACKGROUND Growing experimental evidence has identified neovascularization from the adventitial vasa vasorum and induced intraplaque hemorrhage (IPH) as critical indicators during the development of vulnerable atherosclerotic plaques. In this study, we propose a mathematical model incorporating intraplaque angiogenesis and hemodynamic calculation of the microcirculation, to obtain the quantitative evaluation of the influences of intraplaque neovascularization and hemorrhage on vulnerable plaque ...
Source
#1Jichao Pan (SEU: Southeast University)H-Index: 1
#2Yan Cai (SEU: Southeast University)H-Index: 8
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
view all 7 authors...
Atherosclerotic plaque rupture is responsible for a majority of acute vascular syndromes and this study aims to develop a prediction tool for plaque progression and rupture. Based on the follow-up coronary intravascular ultrasound imaging data, we performed patient-specific multi-physical modeling study on four patients to obtain the evolutional processes of the microenvironment during plaque progression. Four main pathophysiological processes, i.e., lipid deposition, inflammatory response, migr...
2 CitationsSource
#1Mengchen Liu (SEU: Southeast University)
#2Jichao Pan (SEU: Southeast University)H-Index: 1
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
view all 4 authors...
Atherosclerosis is a complex and multi-factorial pathophysiological process. Researches over the past decades have shown that the development of atherosclerotic vulnerable plaque is closely related to its components, morphology, and stress status. Biomechanical models have been developed by combining with medical imaging, biological experiments, and mechanical analysis, to study and analyze the biomechanical factors related to plaque vulnerability. Numerical simulation could quantify the dynamic...
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#1Luping Wang (SEU: Southeast University)
#2Quan Shi (SEU: Southeast University)H-Index: 4
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
view all 6 authors...
Repairing critical-size bone defects with engineered scaffolds remains a challenge in orthopedic practice. Insufficient vascularization is a major reason causing the failure of bone regeneration within scaffolds. Loading exogenous vascular endothelial growth factor (VEGF) in biodegradable polymer scaffolds and controlling its release rate can promote vascularization in scaffolds and accelerate bone regeneration during bone repair. In this study, we developed a 3D mechanical-chemical model of bon...
1 CitationsSource
#1Heming Chen (SEU: Southeast University)H-Index: 2
#1H. Chen (SEU: Southeast University)H-Index: 1
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
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Mathematical models can provide a quantitatively sophisticated description of tumor cell (TC) behaviors under mechanical microenvironment and help us better understand the role of specific biophysical factors based on their influences on the TC behaviors. To this end, we propose an off-lattice cell-based multiscale mathematical model to describe the dynamic growth-induced solid stress during tumor progression and investigate the influence of the mechanical microenvironment on TC invasion. At the...
2 CitationsSource
#1Yang Liu (SEU: Southeast University)H-Index: 5
#1Yang Liu (SEU: Southeast University)H-Index: 79
Last. Ning Gu (SEU: Southeast University)H-Index: 64
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To address the thereapeutic challenges in clinical cancer treatment and guarantee efficient and rapid intracellular delivery of drugs while evading efflux and chemotherapy resistance, herein, we designed a liposomal nanostructure equipped with superparamagnetic iron oxide nanoparticles (SPIOs) and anethole trithione (ADT, a hydrogen sulfide (H2S) donor drug). At first, by spatially focused manipulation of the external static magnetic field (SMF), the SPIOs and ADT-loaded liposomes (SPIOs-ADT-LPs...
5 CitationsSource
#1Xinke Yao (SEU: Southeast University)H-Index: 2
#2Zhengze Dai (Nanjing Medical University)H-Index: 6
Last. Zhiyong Li (SEU: Southeast University)H-Index: 29
view all 7 authors...
Background:Carotid angioplasty and stenting (CAS) is emerging as an alternative treatment for carotid stenosis, but neointimal hyperplasia (NIH) remains a drawback of this treatment strategy. This study aimed to evaluate the effect of variations of carotid bifurcation geometry on local hemodynamics and NIH. Methods and Results:Hemodynamic and geometric effects on NIH were compared between 2 groups, by performing computational fluid dynamics (CFD) simulations both on synthetic models and patient-...
3 CitationsSource
#1Muyi Guo (SEU: Southeast University)H-Index: 2
#2Yan Cai (SEU: Southeast University)H-Index: 8
Last. Zhiyong Li (QUT: Queensland University of Technology)H-Index: 29
view all 3 authors...
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation for the quantitative evaluation of atherosclerotic plaque hemorrhage. An angiogenic microvasculature based on histology of a patient’s carotid plaque is generated by two-dimensional nine-point ...
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