John T. Lafin
University of Texas Southwestern Medical Center
CancerInternal medicineRadiologyOncologymicroRNAProspective cohort studyTeratomaTesticular cancerGerm cell tumorsGonadotropinGerm cellDiseaseMalignancyRetroperitoneal lymph node dissectionFibroblastKRASOrchiectomyRetroperitoneal Lymph NodePost-chemotherapyTesticular Germ Cell TumorTesticular germ cellIn patientChemotherapy naiveSerum micrornaCancer researchCell growthMolecular medicineMedicineBiomarker (medicine)Biology
21Publications
6H-index
72Citations
Publications 23
Newest
#1Jin Piao (SC: University of Southern California)H-Index: 9
#2John T. Lafin (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
view all 14 authors...
Abstract null null Objective null : Circulating microRNAs have clear potential for improving malignant germ-cell-tumor (MGCT) diagnosis. Here, we address the central issue of whether measurement of a single microRNA is sufficient for detecting testicular MGCTs, or whether there is added benefit in quantifying other members of the four-microRNA panel previously identified (miR-371a-3p/miR-372-3p/miR-373-3p and miR-367-3p). null null null Patients/Methods null : We performed a pooled analysis of a...
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#5Gregory T. Chesnut (Walter Reed National Military Medical Center)H-Index: 1
OBJECTIVES To determine whether utilisation of a serum microRNA (miRNA) test could improve treatment appropriateness and cost-effectiveness for patients with Stage I non-seminomatous germ cell tumours (NSGCTs). PATIENTS AND METHODS A decision tree model was built to investigate treatment course, clinical and cost outcomes for patients with Stage IA (T1N0M0S0) and IB (T2-4N0M0S0) NSGCT. The model compared outcomes and cost of standard approach using histopathology, conventional serum tumour marke...
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#1Raj R. Bhanvadia (UTSW: University of Texas Southwestern Medical Center)H-Index: 5
#2Fady Baky (UTSW: University of Texas Southwestern Medical Center)
Last. Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
view all 4 authors...
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#1John T. Lafin (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
#2Matthew J. Murray (University of Cambridge)H-Index: 25
Last. Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
view all 6 authors...
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#1John T. Lafin (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
#2Alexander P. Kenigsberg (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last. Cheryl M. Lewis (UTSW: University of Texas Southwestern Medical Center)H-Index: 18
view all 23 authors...
Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma tissue. The purpose of this study was to explore the role of serum miRNA, including miR-375, in detecting the presence of teratoma at postchemotherapy retroperitoneal lymph node dissection (PC-RPLND). We prospectively collected presurgical serum from 4...
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#1Rohit R. Badia (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Dreaux Abe (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last. Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
view all 12 authors...
387Background: Current serum tumor markers (STMs) for testicular germ cell tumor (GCT) are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a superior mar...
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#1John T. Lafin (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
#2Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
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#1Rohit R. Badia (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Dreaux Abe (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last. Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
view all 24 authors...
Purpose:Current serum tumor markers for testicular germ cell tumor are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a superior marker for malignant (v...
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#1Aditya Bagrodia (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
#2Siamak Daneshmand (SC: University of Southern California)H-Index: 59
Last. John T. Lafin (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
view all 6 authors...
Testicular germ cell tumor (GCT) is the most common malignancy in 18- to 40-year-old men. Unlike most other cancers, GCT is frequently curable even when metastatic. These tumors can be classified histologically into seminoma and non-seminoma, which determines treatment. Therefore, successful treatment requires accurate diagnosis, classification, and monitoring. Serum tumor markers, including lactate dehydrogenase, α-fetoprotein, and β-human chorionic gonadotropin, aid in the classification and s...
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