G. Pauli
University of Strasbourg
Internal medicineSurgeryImmunoglobulin EPathologyDermatologyImmunologyAllergyFood allergyAsthmaRespiratory diseaseSensitizationOccupational asthmaMiteAllergenPollenGynecologyMedicineBiology
Publications 303
#1Huey-Jy Huang (Medical University of Vienna)H-Index: 7
#2Yvonne Resch-Marat (Medical University of Vienna)H-Index: 7
Last. Ekaterina Potapova (Humboldt University of Berlin)H-Index: 1
view all 15 authors...
Background null House dust mite (HDM) allergens are major elicitors of allergic reactions worldwide. null Objective null Identification, characterization, and evaluation of diagnostic utility of a new important HDM allergen was performed. null Methods null A cDNA coding for a new Dermatophagoides pteronyssinus (Dp) allergen, Der p 37, was isolated from a Dp expression library with allergic patients' IgE antibodies. Recombinant Der p 37 (rDer p 37) expressed in Escherichia coli was purified, then...
#1Piotr HumeniukH-Index: 5
#2Pawel DubielaH-Index: 7
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#1Denis Charpin (AMU: Aix-Marseille University)H-Index: 34
#2Myriam RamadourH-Index: 4
Last. Isabella Annesi-MaesanoH-Index: 53
view all 8 authors...
Background: The results of international epidemiological surveys show large geographical variations in skin test reactivity but do not provide a rationale for suc
#1Y. Iwatsubo (InVS: Institut de veille sanitaire)H-Index: 6
#2L. Bénézet (InVS: Institut de veille sanitaire)H-Index: 2
Last. Ellen Imbernon (InVS: Institut de veille sanitaire)H-Index: 29
view all 12 authors...
Objectif L’Institut de veille sanitaire, en partenariat avec la Societe de pneumologie de langue francaise et la societe francaise de medecine du travail, a conduit le projet Onap II entre 2008 et 2014. L’objectif etait d’estimer l’incidence de l’asthme professionnel (AP) dans 6 departements, globalement et par secteur d’activite et profession. Methode Le recueil de donnees a ete realise grâce a un reseau de pneumologues et allergologues hospitaliers et liberaux et de specialistes de consultatio...
#1María Luisa de Lázaro y Torres (Complutense University of Madrid)H-Index: 8
Endo-β-1,3-glucanases are widespread enzymes with glycosyl hydrolitic activity involved in carbohydrate remodelling during the germination and pollen tube growth. Although members of this protein family with allergenic activity have been reported, their effective contribution to allergy is little known. In this work, we identified Fra e 9 as a novel allergenic β-1,3-glucanase from ash pollen. We produced the catalytic and carbohydrate-binding domains as two independent recombinant proteins and c...
#1Srinita Banerjee (Medical University of Vienna)H-Index: 5
#2Yvonne Resch (Medical University of Vienna)H-Index: 12
Last. Susanne Vrtala (Medical University of Vienna)H-Index: 64
view all 22 authors...
House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli a...
#1Metz Favre CH-Index: 1
#2G. PauliH-Index: 39
Last. de Blay FH-Index: 2
view all 5 authors...
We report the case of a patient who first had grass pollinosis associated to food allergy, especially melon, and who developed secondarily early spring pollinosis which could be related to sensitization to the birch profilin. This patient, whose birch pollinosis was confirmed by nasal provocation test, was not sensitized to Bet v 1, the major birch pollen allergen in North Western Europe. We demonstrated by inhibition studies using grass and birch profilins that the clinical birch allergy was in...
Immunoproteomics, IgE-inhibition assays and cDNA-cloning reveals that ash and olive allergenic protein profiles are mostly equivalent, thus explaining their high cross reactivity. Our data suggest simplifying diagnosis of patients by using indistinctly ash or olive pollen.
Background: Ash (Fraxinus excelsior) is an important source of allergenic pollen in temperate areas of Europe. Profilin and polcalcin are 2 important panallergens involved in cross-reactivity between different sources. Objective: To clone and produce Fra e 2 (profilin) and Fra e 3 (polcalcin) as recombinant proteins and evaluate their immunological properties using the natural forms obtained from ash pollen. Methods: Total RNA from ash pollen was used as a template to obtain the specific complem...
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