Masoud Najafi
Kermanshah University of Medical Sciences
CancerInternal medicineDownregulation and upregulationmicroRNAIonizing radiationChemistryTumor microenvironmentInflammationMelatoninCurcuminFibrosisToxicityCancer researchRadiation therapyMedicineBiologyImmune systemCancer cellPharmacology
161Publications
32H-index
3,072Citations
Publications 166
Newest
#1Javid Azadbakht (KAUMS: Kashan University of Medical Sciences)H-Index: 3
#2Daryoush KhoramianH-Index: 2
Last. Hamed Bagheri (Aja University of Medical Sciences)H-Index: 4
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This study aims to review chest computed tomography (CT) scanning parameters which are utilized to evaluate patients for COVID-19-induced pneumonia. Also, some of radiation dose reduction techniques in CT would be mentioned, because using these techniques or low-dose protocol can decrease the radiation burden on the population. Chest CT scan can play a key diagnostic role in COVID-19 patients. Additionally, it can be useful to monitor imaging changes during treatment. However, CT scan overuse du...
4 CitationsSource
#1Zihong Wu (Jianghan University)
Last. Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
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Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs) release several molecules to suppress antitumor immunity and stimulate cancer cell invasion and proliferation....
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#1Xiao Fu (SYU: Shaoyang University)
#2Mu Li (SYU: Shaoyang University)
Last. Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
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Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free radicals and induction of DNA damage. However, cancer cells can acquire some new properties to adapt to anti-cancer agents. An increase in the incidence of apoptosis, mitotic catastrophe, senescence, and necrosis is in favor of overcoming tumor resistance to therapy. Although an increase in the autophagy process may help the ...
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#1Qi Mu (IMUN: Inner Mongolia University for Nationalities)
#2Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
The tumor microenvironment (TME) includes a number of non-cancerous cells that affect cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress tumor growth through induction of cell death in cancer cells, there are various immunosuppressive cells such as regulatory T cells (Tregs), tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), myeloid-derived suppressor cells (MDSCs), etc., which drive cancer cell proliferation. These cells may also su...
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#1Chong Yu (Harbin University of Commerce)
#2Bo Yang (Harbin University of Commerce)
Last. Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
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Cancer is known as a second major cause of death globally. Nowadays, several modalities have been developed for the treatment of cancer. Radiotherapy and chemotherapy are the most common modalities in most countries. However, newer modalities such as immunotherapy and targeted therapy drugs can kill cancer cells with minimal side effects. All anti-cancer agents work based on the killing of cancer cells. Numerous studies are ongoing to kill cancer cells more effectively without increasing side ef...
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#1Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
#2Jamal MajidpoorH-Index: 7
Last. Keywan Mortezaee (Kurdistan University of Medical Sciences)H-Index: 26
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Solid cancers comprise a large number of new cases and deaths from cancer each year globally. There are a number of strategies for addressing tumors raised from solid organs including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy, combinational therapy, and stem cell and extracellular vesicle (EV) therapy. Surgery, radiotherapy, and chemotherapy are the dominant cures, but are not always effective, in which even in a localized tumor there is a possibility of tumor relapse ...
1 CitationsSource
#1Xiao Fu (SYU: Shaoyang University)
#2Yingni He (SYU: Shaoyang University)
Last. Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
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The tumor microenvironment (TME) is made up of several cells and molecules that affect the survival of cancer cells. Indeed, certain (immunosuppressive) cells which promote tumors can promote the growth of tumors by stimulating the proliferation of cancer cells and promoting angiogenesis. During tumor growth, antitumoral immunity includes natural killer cells and CD8+ T cells cannot overcome immunosuppressive responses and cancer cell proliferation. In order to achieve the appropriate therapeuti...
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#1Tayebeh Aryafar (Tehran University of Medical Sciences)H-Index: 2
#2Peyman Amini (Tehran University of Medical Sciences)H-Index: 13
Last. Alireza Shirazi (Tehran University of Medical Sciences)H-Index: 19
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Background: Experimental studies have shown that infiltration of inflammatory cells as well as upregulation of some cytokines play a central role in the development of late effects of ionizing radiation in heart tissues. Evidences have shown that an increased level of TGF-β has a direct correlation with late effects of exposure to ionizing radiation such as chronic oxidative stress and fibrosis. Recent studies have shown that TGF-β, through upregulation of pro-oxidant enzymes such as NOX2 and NO...
2 CitationsSource
#1Qi Mu (IMUN: Inner Mongolia University for Nationalities)
#2Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
Abstract null null Tumor resistance to therapy modalities is one of the major challenges to the eradication of cancer cells and complete treatment. Tumor includes a wide range of cancer and non-cancer cells that play key roles in the proliferation of cancer cells and suppression of anti-tumor immunity. For overcoming tumor resistance to therapy, it is important to have in-depth knowledge relating to intercellular communications within the tumor microenvironment (TME). TME includes various types ...
1 CitationsSource
Cancer patients undergoing radiotherapy, chemotherapy, or targeted cancer therapy are exposed to the risk of several side effects because of the heavy production of ROS by ionizing radiation or some chemotherapy drugs. Damages to DNA, mitochondria, membrane and other organelles within normal tissue cells such as cardiomyocytes and endothelial cells lead to the release of some toxins which are associated with triggering inflammatory cells to release several types of cytokines, chemokines, ROS, an...
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