Johannes Breitling
German Cancer Research Center
SignalPhysicsBiomedical engineeringNoise reductionEndogenyMaterials scienceIn vivoPrincipal component analysisGlioblastomaContrast (vision)Human brainGliomaMagnetization transferAcquisition ProtocolHuman breastDual frequencyCest mriComputer scienceNuclear magnetic resonanceMedicine
29Publications
5H-index
216Citations
Publications 15
Newest
#1Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
#2Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
Last. P Bachert (Heidelberg University)
view all 8 authors...
PURPOSE The value of relaxation-compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)-MRI has already been demonstrated in various neuro-oncological clinical applications. Recently, we translated the approach from 7T to a clinically relevant magnetic field strength of 3T. However, the overall acquisition time was still too long for a broad application in the clinical setting. The aim of this study was to establish a shor...
1 CitationsSource
#1Philip S. Boyd (DKFZ: German Cancer Research Center)H-Index: 3
#2Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 12 authors...
PURPOSE: Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap of several mins. In this study, identification of different types of motion-induced artifacts led to the development of a 3D acquisition protocol for DGE examinations in the human ...
5 CitationsSource
#1Johannes BreitlingH-Index: 5
#2Jan Eric Meissner (DKFZ: German Cancer Research Center)H-Index: 10
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 7 authors...
: Dual-frequency irradiation chemical exchange saturation transfer (dualCEST) allows imaging of endogenous bulk mobile proteins by selectively measuring the intramolecular spin diffusion. The resulting specificity to changes in the concentration, molecular size, and folding state of mobile proteins is of particular interest as a marker for neurodegenerative diseases and cancer. Until now, application of dualCEST in clinical trials was prevented by the inherently small signal-to-noise ratio and t...
1 CitationsSource
#1Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
#2Nina Weinfurtner (DKFZ: German Cancer Research Center)H-Index: 2
Last. P Bachert (Heidelberg University)
view all 9 authors...
PURPOSE: In vivo (31) P MRSI enables noninvasive mapping of absolute pH values via the pH-dependent chemical shifts of inorganic phosphates (Pi ). A particular challenge is the quantification of extracellular Pi with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra- and extracellular pH across the whole human brain via volumetric (31) P MRSI at 7T. METHODS: 3D (31) P MRSI data sets of the brain were acquired from three healthy volunteers and three...
7 CitationsSource
#1Ferdinand Zimmermann (Heidelberg University)H-Index: 3
#2Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 14 authors...
PURPOSE: The application of amide proton transfer (APT) CEST MRI for diagnosis of breast cancer is of emerging interest. However, APT imaging in the human breast is affected by the ubiquitous fat signal preventing a straightforward application of existing acquisition protocols. Although the spectral region of the APT signal does not coincide with fat resonances, the fat signal leads to an incorrect normalization of the Z-spectrum, and therefore to distorted APT effects. In this study, we propose...
9 CitationsSource
#1Jan Eric Meissner (DKFZ: German Cancer Research Center)H-Index: 10
#2Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
Last. Daniel Paech (DKFZ: German Cancer Research Center)H-Index: 20
view all 12 authors...
BACKGROUND: Patients with newly diagnosed inoperable glioma receive chemoradiotherapy (CRT). Standard Response Assessment in Neuro-Oncology (RANO) takes a minimum of 4 weeks after the end of treatment. PURPOSE/HYPOTHESIS: To investigate whether chemical exchange saturation transfer (CEST) MRI enables earlier assessment of response to CRT in glioma patients. STUDY TYPE: Longitudinal prospective study. POPULATION: Twelve brain tumor patients who underwent definitive CRT were included in this study...
22 CitationsSource
#1Jan Eric MeissnerH-Index: 10
#2Johannes BreitlingH-Index: 5
Last. P Bachert
view all 8 authors...
#1Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
#2Yannick Soehngen (DKFZ: German Cancer Research Center)H-Index: 1
Last. Mark E. Ladd (DKFZ: German Cancer Research Center)H-Index: 57
view all 13 authors...
PURPOSE: Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. METHODS: Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral ...
21 CitationsSource
#1Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
#2Anagha Deshmane (MPG: Max Planck Society)H-Index: 12
Last. Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
view all 9 authors...
: High image signal-to-noise ratio (SNR) is required to reliably detect the inherently small chemical exchange saturation transfer (CEST) effects in vivo. In this study, it was demonstrated that identifying spectral redundancies of CEST data by principal component analysis (PCA) in combination with an appropriate data-driven extraction of relevant information can be used for an effective and robust denoising of CEST spectra. The relationship between the number of relevant principal components an...
18 CitationsSource
#1Johannes BreitlingH-Index: 5
#2Anagha Deshmane (MPG: Max Planck Society)H-Index: 12
Last. Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
view all 8 authors...