Loris Menegotti
Acute toxicityMachine learningInternal medicineRadiologyUrologySurgeryOncologyArtificial intelligenceOdds ratioProspective cohort studyProstateFecal incontinenceHemorrhoidsAbdominal surgeryProstate cancerRectumPopulationGynecologyPelvic surgeryRectal toxicityReady to useNomogramRisk factorArtificial neural networkRadiation therapyMedicineGastroenterology
Publications 17
#1Massimo ZecchinH-Index: 17
#2Mara SevergniniH-Index: 7
Last. Giuseppe Boriani (University of Modena and Reggio Emilia)H-Index: 83
view all 11 authors...
Abstract The management of patients with a cardiac implanted electronic device (CIED) receiving radiotherapy (RT) is challenging and requires a structured multidisciplinary approach. A consensus document is presented as a result of a multidisciplinary working group involving cardiac electrophysiologists, radiation oncologists and physicists in order to stratify the risk of patients with CIED requiring RT and approaching RT sessions appropriately. When high radiation doses and beam energy higher ...
29 CitationsSource
1 CitationsSource
#1Gianni FellinH-Index: 17
#2Tiziana Rancati (UniSR: Vita-Salute San Raffaele University)H-Index: 27
Last. Riccardo Valdagni (UniSR: Vita-Salute San Raffaele University)H-Index: 51
view all 18 authors...
Abstract Purpose To prospectively evaluate long-term late rectal bleeding (lrb) and faecal incontinence (linc) after high-dose radiotherapy (RT) for prostate cancer in the AIROPROS 0102 population, and to assess clinical/dosimetric risk factors. Materials and methods Questionnaires of 515 patients with G0 baseline incontinence and bleeding scores (follow-up ⩾6years) were analysed. Correlations between lrb/linc and many clinical and dosimetric parameters were investigated by univariate and multiv...
27 CitationsSource
#1Riccardo ValdagniH-Index: 51
#2Vittorio VavassoriH-Index: 18
Last. C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
view all 13 authors...
Purpose: To evaluate and discuss the role of specific types of abdominal surgery (SURG) before radical radiation therapy as a risk factor for late rectal toxicity in prostate cancer patients. Methods: Results concerning questionnaire-based scored late bleeding and faecal incontinence in 718 patients with a complete follow-up of 36 months were analysed, focusing on the impact of specific pre-radiotherapy abdominal/pelvic surgery procedures. Patients were accrued in the prospective study AIROPROS ...
32 CitationsSource
#1Mauro CarraraH-Index: 16
#2S. TomatisH-Index: 1
Last. Riccardo ValdagniH-Index: 51
view all 10 authors...
#1Riccardo ValdagniH-Index: 51
#2Michael W. Kattan (Cleveland Clinic Lerner College of Medicine)H-Index: 10
Last. C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
view all 16 authors...
Purpose Development of user-friendly tools for the prediction of single-patient probability of late rectal toxicity after conformal radiotherapy for prostate cancer. Methods and Materials This multicenter protocol was characterized by the prospective evaluation of rectal toxicity through self-assessed questionnaires (minimum follow-up, 36 months) by 718 adult men in the AIROPROS 0102 trial. Doses were between 70 and 80 Gy. Nomograms were created based on multivariable logistic regression analysi...
38 CitationsSource
#1S. TomatisH-Index: 13
#2Tiziana RancatiH-Index: 27
Last. Riccardo ValdagniH-Index: 51
view all 16 authors...
The aim of this study was to develop a model exploiting artificial neural networks (ANNs) to correlate dosimetric and clinical variables with late rectal bleeding in prostate cancer patients undergoing radical radiotherapy and to compare the ANN results with those of a standard logistic regression (LR) analysis. 718 men included in the AIROPROS 0102 trial were analyzed. This multicenter protocol was characterized by the prospective evaluation of rectal toxicity, with a minimum follow-up of 36 mo...
34 CitationsSource
Purpose To model late fecal incontinence after high-dose prostate cancer radiotherapy (RT) in patients accrued in the AIROPROS (prostate working group of the Italian Association of Radiation Oncology) 0102 trial using different endpoint definitions. Methods and Materials The self-reported questionnaires (before RT, 1 month after RT, and every 6 months for ≤3 years after RT) of 586 patients were available. The peak incontinence (P_INC) and two longitudinal definitions (chronic incontinence [C_INC...
29 CitationsSource
#1Tiziana RancatiH-Index: 27
#2C. FiorinoH-Index: 7
Last. Riccardo ValdagniH-Index: 51
view all 12 authors...
Abstract Background and purpose To fit an NTCP model including clinical risk factors to late rectal toxicities after radiotherapy for prostate cancer. Methods and materials Data of 669 patients were considered. The probability of late toxicity within 36months (bleeding and incontinence) was fitted with the original and a modified Logit-EUD model, including clinical factors by fitting a subset specific TD 50 s: the ratio of TD 50 s with and without including the clinical variable was the dose-mod...
52 CitationsSource
4 CitationsSource