Fiona J. Campbell
Royal Liverpool and Broadgreen University Hospital NHS Trust
CancerInternal medicineRadiologyPathologyStromal cellPediatricsProspective cohort studyMyofibroblastPancreatitisGastrinCarcinomaGestational agePancreatectomyNeuroendocrine tumorsDiseaseAchlorhydriaPancreatic cancerAtrophic gastritisKRASIncidence (epidemiology)Cancer researchMedicineChromogranin ABiologyGastroenterology
Publications 29
#1Derek A. O'Reilly (University of Manchester)H-Index: 23
#2Linyun Fou (National Institute for Health and Care Excellence)H-Index: 1
Last. John P. Neoptolemos (Heidelberg University)H-Index: 124
view all 21 authors...
Abstract To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effec...
23 CitationsSource
#1Irene SangradorH-Index: 1
#2Xavier Molero (Autonomous University of Barcelona)H-Index: 20
Last. Eva C. Vaquero (University of Barcelona)H-Index: 22
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The transcription factor Zeb1 has been identified as a crucial player in Kras-dependent oncogenesis. In pancreatic ductal adenocarcinoma (PDAC), Zeb1 is highly expressed in myofibroblasts and correlates with poor prognosis. As Kras mutations are key drivers in PDAC, we aimed here to assess the necessity of Zeb1 for Kras-driven PDAC and to define the role of Zeb1-expressing myofibroblasts in PDAC development. Genetically engineered mice with conditional pancreatic KrasG12D and Trp53 mutations (KP...
5 CitationsSource
#1Paula Ghaneh (University of Liverpool)H-Index: 61
#2Robert Hanson (University of Liverpool)H-Index: 1
Last. John P. Neoptolemos (University of Liverpool)H-Index: 124
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BACKGROUND: Pancreatic cancer diagnosis and staging can be difficult in 10-20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value to the diagnosis and staging of pancreatic cancer. OBJECTIVE: To determine the incremental diagnostic accuracy and impact of PET/CT in addition to standard diagnostic work-up in patients with suspected pancreatic cancer. DESIGN: A multicentre prospect...
76 CitationsSource
#1Paula Ghaneh (University of Liverpool)H-Index: 61
#2Jörg KleeffH-Index: 95
Last. John P. NeoptolemosH-Index: 124
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Objective and Background:Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies.Methods:Analyses were carried out to assess the association between clinical
85 CitationsSource
#1Irene SangradorH-Index: 1
#2Xavier MoleroH-Index: 20
Last. Eva C. VaqueroH-Index: 22
view all 7 authors...
#1Malcolm BoyceH-Index: 20
#2Andrew R. Moore (University of Liverpool)H-Index: 8
Last. D. Mark Pritchard (University of Liverpool)H-Index: 28
view all 9 authors...
Aims Netazepide, a gastrin/CCK2 receptor antagonist, once daily for 12 weeks reduced the number of tumours and size of the largest one in 16 patients with autoimmune chronic atrophic gastritis (CAG), achlorhydria, hypergastrinaemia and multiple gastric neuroendocrine tumours (type 1 gastric NETs), and normalised circulating chromogranin A (CgA) produced by enterochromaffin-like cells, the source of the tumours. The aim was to assess whether longer-term netazepide treatment can eradicate type 1 g...
21 CitationsSource
#1Evan J. Anderson (Emory University)H-Index: 32
Last. Bosco PaesH-Index: 49
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Moderate-late preterm infants, 33-35 weeks' gestational age (wGA), are at increased risk for respiratory syncytial virus hospitalization (RSVH). The objective of this study is to quantify the burden of RSVH in moderate-late preterm infants.A pooled analysis was conducted on RSVH from 7 prospective, observational studies in the Northern Hemisphere from 2000 to 2014. Infants' 33-35 wGA without comorbidity born during the respiratory syncytial virus season who did not receive respiratory syncytial ...
19 CitationsSource
#1Zbyněk Straňák (Charles University in Prague)H-Index: 6
#2Elie Saliba (François Rabelais University)H-Index: 26
Last. Fiona J. CampbellH-Index: 9
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Background Preterm infants are at high risk of developing respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI). This observational epidemiologic study evaluated RSV disease burden and risk factors for RSV-associated LRTI hospitalization in preterm infants 33 weeks+0 days to 35 weeks+6 days gestational age not receiving RSV prophylaxis. Methods Preterm infants ≤6 months of age during RSV season (1 October 2013–30 April 2014) were followed at 72 sites across 23 cou...
23 CitationsSource
#1Barbara WhelanH-Index: 1
#2Elles MustersH-Index: 1
Last. Fiona J. CampbellH-Index: 9
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Severe infection of infants with respiratory syncytial virus (RSV) is a leading cause of morbidity in the developed world and mortality in the developing world. Prophylaxis using palivizumab in infants at risk for severe RSV disease reduces the rate of hospitalisation in this population of children. To ensure complete prophylaxis, infants must receive monthly doses over the winter season. To improve parental convenience, the Synacare® programme was implemented in Ireland and the Netherlands. Syn...
6 CitationsSource
#1Claire JenkinsonH-Index: 12
#2Victoria ElliottH-Index: 13
Last. Eithne CostelloH-Index: 51
view all 15 authors...