Shanyu Ye
Guangzhou University of Chinese Medicine
Therapeutic effectEndosomeStress granuleGene silencingPhosphorylationDownregulation and upregulationChromatin immunoprecipitationDopaminergicCaspase 1microRNACellGene expressionGPX4Tyrosine hydroxylaseRNA interferencePyroptosisGene knockdownChemistryApoptosisMesenchymal stem cellRho-associated protein kinaseIn vivoStimulationNeuroprotectionWestern blotInflammationArthritisWedelolactoneInflammasomeMoxibustionSorting nexinROCK2Parkinson's diseaseSubstantia nigraAtractylodes lanceaOncogeneSuper-enhancerFTH1Neural degenerationCell cycleMir 181a 5pMethylationChondrogenesisReactive oxygen speciesSecretionCancer researchViability assayIschemiaFlow cytometryMedicineBiologyMethyltransferaseCell biologyPharmacology
8Publications
3H-index
23Citations
Publications 8
Newest
Abstract null null Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide. Recent studies revealed that the ferroptosis pathway is involved in the death process of dopaminergic neurons in PD. The aberrant endosomal sorting pathway, which results in aberrant iron level in eukaryotic cells, may serve a role in the ferroptosis pathway in PD condition. However, its specific molecular mechanisms remained unclear. In the present study, we performed chromatin immunopr...
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#1Zifeng Huang (Guangzhou University of Chinese Medicine)H-Index: 2
#2Wenwen SiH-Index: 1
Last. Meiling ZhuH-Index: 4
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Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxid...
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#1Xinrong LiH-Index: 2
#2Wenwen SiH-Index: 4
Last. Meiling ZhuH-Index: 4
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Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). In a previous study, the authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis in a model of 6‑hydroxydopamine (6‑OHDA)‑induced PD. However, whether and how microRNAs (miRNAs/miRs) modulate FTH1 in PD ferroptosis is not yet well understood. In the present study, in vivo and in vitro models of PD induced by 6‑OHDA were establishe...
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#1Shanyu YeH-Index: 3
#2Wenwen SiH-Index: 1
view all 10 authors...
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#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Zhen Li (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
view all 9 authors...
As a sensitive cold-shock protein, RNA binding protein motif 3 (RBM3) exhibits a neuroprotective function in the condition of brain injury. However, how RBM3 is involved in acute ischemic stroke by affecting stress granules (SGs) remains unclear. Here, we established an oxygen-glucose deprivation/reperfusion (OGD/R) model in rat primary cortical neurons and PC12 cells to explore the potential mechanism between RBM3 and SG formation in acute ischemic/reperfusion (I/R) condition. The immunofluores...
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#1Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 2
#2Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 24
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OBJECTIVES Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti-inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages and its influence on MSU-induced inflammation. MATERIALS AND METHODS BMDM, J774A.1 and PMA-differentiated THP-1 macrophages were primed with LPS and then stimulated with ATP or nigericin or MSU crystal ...
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#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yi Li (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling ZhuH-Index: 4
view all 8 authors...
The modification of methyltransferase-like (METTL) enzymes plays important roles in various cellular responses by regulating microRNA expression. However, how m6A modification is involved in stress granule (SG) formation in the early stage of acute ischemic stroke by affecting the biogenesis processing of microRNAs remains unclear. Here, we established a middle cerebral artery occlusion (MCAO) model in rats and an oxygen-glucose deprivation/reperfusion (OGD/R) model in primary cortical neurons a...
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#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Shanyu Ye (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 24
view all 11 authors...
: Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were p...
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