Natasha Bertelsen
Istituto Italiano di Tecnologia
Functional specializationBiological neural networkPhenotypeAssociation (psychology)Nonverbal communicationHippocampal formationPsychologyNeuroscienceHyperconnectivityAutismVocal learningNeurodevelopmental disorderHippocampusWilliams syndromeEarly languageCortical surfaceRepetitive behaviorGenetic heterogeneityResting state fMRIBiologyEpisodic memory
9Publications
1H-index
9Citations
Publications 10
Newest
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC >...
Source
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
view all 0 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Elena Maria Busuoli (IIT: Istituto Italiano di Tecnologia)
Last. Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
view all 14 authors...
Early detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on outcome is poorly understood. While clinical traits such as language ability have been shown to predict treatment outcome, whether or not and how information at the genomic level can predict treatment outcome is unknown. Leveraging a cohort of toddlers with autism who all received the same standardized intervention at a very young age and pr...
Source
#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (97-99%) out-of-sample SC=RRB, SC>RRB,...
Source
#1Marilina Mastrogiuseppe (University of Trento)H-Index: 2
#2Natasha Bertelsen (University of Trento)H-Index: 1
Last. Sang Ah Lee (KAIST)H-Index: 20
view all 4 authors...
Source
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
#2Lisa T Eyler (Veterans Health Administration)H-Index: 1
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regional identities develop through anterior-posterior (A-P) and dorsal-ventral (D-V) prenatal genomic patterning gradients. Here we find that A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) is intact in typically developing and autistic toddlers with good language outcome, but is absent in autistic toddlers with poor early language outcome. Genes driving this effect are prominent in midgestational A-P and D-V gene expression gradients and prenatal cell t...
1 CitationsSource
#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Abstract Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and is underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (96-98%) out-of-sample SC=RRB, SC...
Source
#1Marilina Mastrogiuseppe (UniTS: University of Trieste)H-Index: 2
#2Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
Last. Sang Ah Lee (KAIST)H-Index: 20
view all 4 authors...
Recent theories of episodic memory (EM) posit that the hippocampus provides a spatiotemporal framework necessary for representing events. If such theories hold true, then does the development of EM in children depend on the ability to first bind spatial and temporal information? And does this ability rely, at least in part, on normal hippocampal function? We investigated the development of EM in children 2–8 years of age (Study 1) and its impairment in Williams Syndrome, a genetic neurodevelopme...
4 CitationsSource
#1Marilina Mastrogiuseppe (University of Trento)H-Index: 2
#2Natasha Bertelsen (University of Trento)H-Index: 1
Last. Sang Ah Lee (KAIST)H-Index: 20
view all 4 authors...
Recent theories of episodic memory propose that the hippocampus provides the spatiotemporal framework for episodic memories. If this is true, does the development of episodic memory depend on the binding of space and time? And does this rely, at least partly, on normal hippocampal function? We investigated the development of episodic memory in children 2-8 years of age (Study 1) and its impairment in Williams Syndrome (Study 2) by implementing a nonverbal object- placement task that dissociates ...
Source