Zhuo-Hui Luo
Guangzhou University of Chinese Medicine
FrizzledEndocrinologyWnt signaling pathwayLipogenesisWhite adipose tissueAdipose tissueLRP5KinaseChemistryTLR4RUNX2Morinda officinalisOsteoblastFatty liverRANKLOsteoprotegerinLipid metabolismOvariectomized ratCell biologyPharmacology
6Publications
2H-index
10Citations
Publications 6
Newest
#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jia-Wen Huang (Guangzhou University of Chinese Medicine)
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Abstract Background We had reported that cajanolactone A (CLA) from Cajanus cajan dose-dependently inhibited ovariectomy-induced obesity and liver steatosis in mice, showing potential to prevent postmenopausal obesity and fatty liver. In this study, the role of CLA in the regulation of energy and lipid homeostasis was investigated. Methods Ovariectomized mice treated with CLA or vehicle for 12 weeks were performed a 48 h monitoring for energy metabolism and food uptake. After that, hypothalami, ...
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#1Zhi-Wen Liu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Abstract Background Osteoporosis is a systemic skeletal disease that leads to a high risk for bone fractures. Morinda officinalis How. has been used as osteoporosis treatment in China. However, its mechanism of action as an anti-osteoporotic herb remains unknown. Methods A network pharmacology approach was applied to explore the potential mechanisms of action of M. officinalis in osteoporosis treatment. The active compounds of M. officinalis and their potential osteoporosis-related targets were ...
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#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Zhi-Wen Liu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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ABSTRACT BACKGROUND : Visceral obesity and fatty liver are prevalent in postmenopausal women. The stilbene-rich extract of Cajanus cajan (L.) Millsp. has been reported to prevent ovariectomy-induced and diet-induced weight gain in animal models, and stilbenoids from C. cajan are thought to have the potential to prevent postmenopausal obesity and fatty liver. PURPOSE : Cajanolactone A (CLA) is the main stilbenoid from C. cajan with osteoblastogenic promoting activity. This study investigated the ...
1 CitationsSource
#1Zhao Qu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yan Chen (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
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OBJECTIVES: Neuroprotective potential of 7-methoxyflavanone (7MF) and its underlying mechanism was investigated. METHODS: Inhibitory effects of 7MF on microglial activation and neuroinflammation were evaluated by employment of lipopolysaccharide (LPS)-induced BV2 microglial cells. Changes in expression of genes and proteins of interest were investigated by RT-qPCR analysis and Western blot analysis. Inhibitory effects of 7MF on microglial overactivation were verified in LPS-treated C57BL/6J mice...
2 CitationsSource
#1Bin Xie (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yuan-Yuan Lu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 2
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Abstract Ethnopharmacological relevance Marsdenia tenacissima (Roxb.) Wight et Arn is a vine distributed in southwest area of China and used in folk medicine for treatment of tumors. Recent decades of studies on this plant reveal its synergistic effects with certain anticancer drugs in cancer therapy. In our previous study, an extract ETA which contains total aglycones made from M. tenacissima significantly enhanced antitumor activity of paclitaxel in tumor-bearing mice. However, the effective c...
4 CitationsSource
#1Shan Liu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
view all 9 authors...
Cajanolactone A (CLA) is a stilbenoid discovered by us from Cajanus cajan (L.) Millsp. In our study, CLA was found to promote osteoblast differentiation in human bone marrow mesenchymal stem cells (hBMSCs), as judged by increased cellular alkaline phosphatase activity and extracellular calcium deposits, and elevated protein expression of Runx2, collagen-1, bone morphogenetic protein-2, and osteopontin. Mechanistic studies revealed that hBMSCs undergoing osteoblast differentiation expressed upreg...
5 CitationsSource