Shizhou Qi
Shenyang Pharmaceutical University
Proton NMRCytotoxicityDocking (molecular)Circular dichroismRhizomeCytotoxic T cellMedicinal chemistryGenusCatalysisCarbon-13 NMRProinflammatory cytokineEnzymeChemistryApoptosisGlycosidePhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroMyeloperoxidaseTransformation (genetics)Absolute configurationG1 phaseColitisActinidia argutaLactamOxidative stressPhenylpropanoidMoietyCaesalpiniaLactoneInflammationLeptopusHeLaNitric oxide synthaseAntioxidantCaesalpinia bonducLipopolysaccharideEuphorbiaceaeMedicinal plantsAromatizationNatural productAnti-inflammatoryTarget proteinAtractylodes lanceatert-Butyl hydroperoxideLeptopus chinensisSaussurea involucrataAcid catalyzedDried fruitPentacyclic triterpenoidsNo productionReactive oxygen speciesNitric oxideViability assayYield (chemistry)BiosynthesisBiochemistryTraditional medicineMAPK/ERK pathwayPhosphodiesteraseStereochemistryProtein kinase BHydrolysisPharmacology
9Publications
4H-index
19Citations
Publications 10
Newest
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Siyu Yu (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Eighteen cassane diterpenoids, including five new lactam-type (4-8), 12 new lactone-type (1-3 and 9-17), and one known compound (18), were isolated from Caesalpinia sinensis. To our knowledge, this is the first study on the seed kernels of C. sinensis, and cassane derivatives were discovered in this plant for the first time. Their structures including absolute configurations were established by extensive spectroscopic methods complemented with single-crystal X-ray diffraction analyses and ECD ca...
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#1Ting LiuH-Index: 1
Last. Huiyuan GaoH-Index: 12
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 9 authors...
Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Liping LongH-Index: 3
Last. Huiyuan GaoH-Index: 12
view all 9 authors...
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#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xiang Li (SPU: Shenyang Pharmaceutical University)
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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In this study, phytochemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc led to the isolation of two new cassane-type diterpenoids, norcaesalpinin Q (1) a...
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#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 10 authors...
Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lushan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractSix sesquiterpenoids and four lignans (1–10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2–4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In...
5 CitationsSource
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractSaussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7...
4 CitationsSource
#1Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 9 authors...
Abstract In this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5) and seven known compounds (6-12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism) spectral analysis. The characters for new compounds with the presence of an aromatized C ring...
5 CitationsSource
#1Lian LianH-Index: 1
#2Song Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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In this study, we aimed at investigating the antiinflammatory activity of the freeze-dried fruit powder of Actinidia arguta (FAA) on dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice and the effect of its extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. For pharmacodynamic studies, the oral administration of FAA (300 or 600 mg kg−1) could decrease the disease activity index (DAI), reduce the incidence of colon and spleen edemas (caused by inflammation), a...
5 CitationsSource