Fleur van der Sijde
Erasmus University Rotterdam
GeneCronbach's alphaRNA extractionInternal medicinePeripheral blood mononuclear cellOncologyGene expressionMolecular biologyWhole bloodStromal cellGene expression profilingPhysical therapyObservational studySystemic inflammationChemotherapyInflammationFOLFIRINOXLymphocyteAdjuvantAdjuvant therapyAnklePancreasDiseaseADAM12Peripheral blood cellPancreatic cancerGemcitabinePopulationPeriampullary cancerCirculating MicroRNAObjective responseCirculating biomarkersIncidence (epidemiology)Reliability (statistics)Construct validityProportional hazards modelStromaFicollScale (social sciences)RNAOrthopedic surgeryMedicineCohortAbsolute neutrophil countBiologyGastroenterologyPhysical medicine and rehabilitation
5Publications
4H-index
30Citations
Publications 10
Newest
#1Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
#2Laura Schafthuizen (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Casper H.J. van Eijck (EUR: Erasmus University Rotterdam)H-Index: 72
view all 7 authors...
Quality of life in cancer patients might be affected by chemotherapy-induced toxicity. Especially in patients with pancreatic ductal adenocarcinoma (PDAC), with a short life expectancy, fear of poor quality of life is often a reason for both patients and medical oncologists to refrain from further treatment. In this study, we investigated quality of life (QoL), pain, sleep, and activity levels in locally advanced pancreatic cancer (LAPC) patients after FOLFIRINOX treatment. A total of 41 LAPC pa...
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In this study, we explored the predictive value of serum microRNA (miRNA) expression for early tumor progression during FOLFIRINOX chemotherapy and its association with overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). A total of 132 PDAC patients of all disease stages were included in this study, of whom 25% showed progressive disease during FOLFIRINOX according to the RECIST criteria. MiRNA expression was analyzed in serum collected before the start and after one ...
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#1Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
#2Zakia Azmani (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Quisette P Janssen (EUR: Erasmus University Rotterdam)H-Index: 4
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Background:Biomarkers predicting treatment response may be used to stratify pancreatic ductal adenocarcinoma (PDAC) patients for therapy. The aim of this study was to identify circulating tumor DNA...
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#2Dana A. M. MustafaH-Index: 12
Last. Casper H.J. van EijckH-Index: 72
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ABSTRACT To date, little advances have been made toward new and more effective therapies for pancreatic ductal adenocarcinoma (PDAC). Discovery of prognostic and predictive biomarkers is needed to stratify patients for available treatments and to elucidate how new therapies could be developed. Recent studies have made clear that the immune system is not only affected in the microenvironment of the primary tumor and it is also systemically disrupted in PDAC patients. Under normal circumstances, t...
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#1Marin Strijker (UvA: University of Amsterdam)H-Index: 9
#2Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
Last. Maarten F. BijlsmaH-Index: 19
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Abstract Background We evaluated the stroma marker A Disintegrin And Metalloprotease 12 (ADAM12) as a preoperative prognostic and treatment-predictive marker for overall survival (OS) in pancreatic ductal adenocarcinoma (PDAC) and periampullary cancers. Methods Materials were derived from the prospective nationwide Dutch Pancreas Biobank (2015-2017). We included patients who underwent resection because of PDAC/periampullary cancer or non-invasive IPMN (control group) and had a preoperative serum...
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#1Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
#2Yunlei Li (EUR: Erasmus University Rotterdam)H-Index: 9
Last. Dana A. M. Mustafa (EUR: Erasmus University Rotterdam)H-Index: 12
view all 6 authors...
Monitoring changes in the immune profile in blood samples can help identifying changes in tumor biology and therapy responsiveness over time. Immune-related gene expression profiles offer a highly reproducible method to monitor changes of the immune system. However, measuring gene expression profiles in whole blood samples can be complicated because of the high protein and enzyme abundancy that affect the stability and quality of the RNA. Peripheral blood mononuclear cells (PBMCs) are one the mo...
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#1Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
#2Eveline E. Vietsch (EUR: Erasmus University Rotterdam)H-Index: 2
Last. Casper H.J. van Eijck (EUR: Erasmus University Rotterdam)H-Index: 72
view all 5 authors...
Abstract Background Several peripheral blood cell counts and immune ratios, such as the systemic immune-inflammation index (SII = neutrophil count/lymphocyte count x platelet count) have prognostic value in patients with resectable pancreatic cancer (PDAC). Circulating microRNAs (miRNAs) are involved in various aspects of cancer and inflammation. We aimed to identify measurable circulating miRNAs in PDAC patients correlating with systemic inflammation parameters. Methods A total of 42 PDAC patie...
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#1Eveline E. Vietsch (Georgetown University)H-Index: 7
#2Ivana Peran (Georgetown University)H-Index: 2
Last. Anton Wellstein (Georgetown University)H-Index: 67
view all 8 authors...
Clinical follow-up aided by changes in the expression of circulating microRNAs (miRs) may improve prognostication of pancreatic ductal adenocarcinoma (PDAC) patients. Changes in 179 circulating miRs due to cancer progression in the transgenic KrasG12D/+; Trp53R172H/+; P48-Cre (KPC) animal model of PDAC were analyzed for serum miRs that are altered in metastatic disease. In addition, expression levels of 250 miRs were profiled before and after pancreaticoduodenectomy in the serum of two patients ...
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#1Fleur van der Sijde (EUR: Erasmus University Rotterdam)H-Index: 4
#2Eveline E. Vietsch (EUR: Erasmus University Rotterdam)H-Index: 2
Last. Casper H.J. van Eijck (EUR: Erasmus University Rotterdam)H-Index: 72
view all 6 authors...
Pancreatic cancer is a lethal disease with increasing incidence. Most patients present with advanced disease, for which palliative systemic chemotherapy is the only therapeutic option. Despite improved median survival rates with FOLFIRINOX or gemcitabine chemotherapy compared to the best supportive care, many individual patients may not benefit from chemotherapy. Biomarkers are needed to predict who will benefit from chemotherapy and to monitor a patient’s response to chemotherapy. This review s...
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#1A. Siebe De Boer (EUR: Erasmus University Rotterdam)H-Index: 6
#2Roderik J C Tjioe (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Esther M.M. Van Lieshout (EUR: Erasmus University Rotterdam)H-Index: 33
view all 9 authors...
Objectives The American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale is among the most commonly used instruments for measuring outcome of treatment in patients who sustained a complex ankle or hindfoot injury. It consists of a patient-reported and a physician-reported part. A validated, Dutch version of this instrument is currently not available. The aim of this study was to translate the instrument into Dutch and to determine the measurement properties of the AOFAS Ankle-Hind...
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