Ryo Fujita
Hokkaido University
Internal medicineUrologyIncinerationEndocrinologyRetrospective cohort studyLeachateBone remodelingMaterials scienceOsteoclastOsteoporosisBisphosphonateCrushed stoneCementitiousJuvenile osteoporosisWaste managementSludgeBone resorptionOrthopedic surgeryMedicineMunicipal solid wasteFly ash
12Publications
5H-index
50Citations
Publications 14
Newest
#1Tsutomu Endo (Hokkaido University)H-Index: 6
#2Yoshinao Koike (Hokkaido University)H-Index: 3
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 16 authors...
Study Design:Retrospective cross-sectional study.Objectives:There is insufficient data on the clinical features of ossification of the ligamentum flavum (OLF) of the thoracic spine and the risk of ...
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#1Tsutomu Endo (Hokkaido University)H-Index: 6
#2Yoshinao Koike (Hokkaido University)H-Index: 3
Last. Yuichi HasegawaH-Index: 1
view all 19 authors...
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a sing...
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#1Takeru Tsujimoto (Hokkaido University)H-Index: 5
#2Tsutomu EndoH-Index: 6
Last. Masahiko TakahataH-Index: 30
view all 11 authors...
STUDY DESIGN A retrospective observational study. OBJECTIVE To clarify the exceptional conditions for a favorable neurological recovery after laminoplasty (LMP) for cervical myelopathy caused by K-line (-) ossification of the posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA The K-line-based classification of cervical OPLL was developed to predict insufficient neurological recovery after LMP. For patients with K-line (-) OPLL, LMP generally yields the least improvement because o...
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#1Hideyuki Kobayashi (Hokkaido University)H-Index: 2
#2Ryo Fujita (Hokkaido University)H-Index: 5
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 8 authors...
Osteomyelitis is characterized by progressive inflammatory bone destruction accompanied by severe pain and disability. However, with the exception of antibiotic therapies, there is no established therapy to protect the bone from infectious osteolysis. The anti-receptor activator of nuclear factor-kB ligand (RANKL) monoclonal antibody (anti-RANKL Ab) is a potential drug based on its proven effectiveness in preventing joint bone erosion in rheumatoid arthritis; however, the efficacy and adverse ef...
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#1Tomohiro Shimizu (Hokkaido University)H-Index: 11
#2Kosuke Arita (Hokkaido University)
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
Purpose We aimed to investigate the longitudinal changes in bone metabolic markers and bone mineral density (BMD) after starting or switching from bisphosphonate (BP) to romosozumab (ROMO) or denosumab (DENO) therapies over 12 months and to determine predictors that establish associations with changes in BMD among the patients received the ROMO therapy. Methods Postmenopausal osteoporosis patients with a high risk of fracture-154 in total-were recruited; their therapies were switched to ROMO or ...
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#1Ryo Fujita (Hokkaido University)H-Index: 5
#2Itaru Oda (Memorial Hospital of South Bend)H-Index: 8
Last. Yoshiharu Kawaguchi (University of Toyama)H-Index: 46
view all 7 authors...
Abstract Background Despite repeated efforts for accurate cervical pedicle screw insertion, malpositioning of the inserted screw is commonly noted. To avoid neurovascular complications during cervical pedicle screw insertion, we have developed a new patient-specific screw guide system. This study aimed to evaluate the accuracy of cervical PS placement using the new patient-specific screw guide system. Methods This study is a retrospective clinical evaluation of prospectively enrolled patients. S...
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#1Hiromi Kimura-Suda (Chitose Institute of Science and Technology)H-Index: 11
#2Fumiya Nakamura (Chitose Institute of Science and Technology)H-Index: 2
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 8 authors...
Bone quality is a combination of the material and structural properties of bone. Reductions in bone quality parameters, such as the degree of collagen fiber orientation, mineralization, mineral mat...
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#1Ryo Fujita (Hokkaido University)H-Index: 5
#2Masahiro Ota (Hokkaido University)H-Index: 8
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 10 authors...
The efficacy and renal safety of low-dose/high-frequency (LDHF) dosing and high-dose/low-frequency (HDLF) dosing of bisphosphonates (BPs) are comparable in patients with normal kidney function but might be different in patients with late-stage chronic kidney disease (CKD). This study aimed to compare the efficacy and renal safety of two different dosage regimens of a BP, alendronate (ALN), in stage 4 CKD using a rat model. Male, 10-week-old Sprague-Dawley rats were subjected to either 5/6 nephre...
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#1Dai Sato (Hokkaido University)H-Index: 6
#2Masahiko Takahata (Hokkaido University)H-Index: 30
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 12 authors...
Effective treatment of juvenile osteoporosis, which is frequently caused by glucocorticoid (GC) therapy, has not been established due to limited data regarding the efficacy and adverse effects of antiresorptive therapies on the growing skeleton. We previously demonstrated that sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) targeting therapy, which interferes with osteoclast terminal differentiation in the secondary, but not primary, spongiosa, increased bone mass without adverse e...
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#1Ryo Fujita (Hokkaido University)H-Index: 5
#2Hiroki Hamano (Hokkaido University)H-Index: 7
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 10 authors...
Breast cancer is one of the most prevalent malignancies in women, and approximately 75–80% of patients with advanced breast cancer develop bone metastasis. Expression of the cancer-associated carbohydrate antigen sialyl-Tn (STn) in breast cancer is associated with a poor prognosis; however, involvement of STn in the development of metastatic bone lesions remains unclear. We investigated whether STn expression on breast cancer cells influences intraosseous tumor growth and bone response in mice m...
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