Minshi Liang
Guangzhou University of Chinese Medicine
AdductRadicalMedicinal chemistryMass spectrometryHigh-performance liquid chromatographyAqueous solutionChemistryMesenchymal stem cellAcid dissociation constantMechanism of actionGalactosideHyperosideLicochalcone ALactate dehydrogenaseMetaboliteAntioxidantMyricetinGallic acidSubstituentFlavonolsAglyconeDimerABTSProtocatechuic acidQuercetinDPPHTandem mass spectrometryElectrospray ionizationChromatographyBiochemistryStereochemistry
Publications 4
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jingyuan Zeng (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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In this study, the anti-ferroptosis effects of catecholic flavonol quercetin and its metabolite quercetin Diels-Alder anti-dimer (QDAD) were studied using an erastin-treated bone marrow-derived mesenchymal stem cell (bmMSCs) model. Quercetin exhibited higher anti-ferroptosis levels than QDAD, as indicated by 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid (C11-BODIPY), 2′,7′-dichlorodihydrofluoroscein diacetate (H2DCFDA), lactate dehydrogenase (LDH) relea...
13 CitationsSource
#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 8
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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Background Pyrola decorata H. Andres, is exclusively distributed in China and a source of traditional Chinese herbal medicine Luxiancao for more than 2000 years. Here, we evaluated the antioxidant and cytoprotective effects of P. decorata and its five phenolic components (protocatechuic acid, gallic acid, hyperoside, 2′′-O-galloylhyperin, and quercetin), and discussed their antioxidant chemistry.
6 CitationsSource
#1Xican LiH-Index: 19
#2Xiaojian OuyangH-Index: 5
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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The biological process, 3-O-galactosylation, is important in plant cells. To understand the mechanism of the reduction of flavonol antioxidative activity by 3-O-galactosylation, myricetin-3-O-galactoside (M3OGa) and myricetin aglycone were each incubated with 2 mol α,α-diphenyl-β-picrylhydrazyl radical (DPPH•) and subsequently comparatively analyzed for radical adduct formation (RAF) products using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-fl...
10 CitationsSource
#1Minshi Liang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 5 authors...
Echinatin and its 1,1-dimethyl-2-propenyl derivative licochalcone A are two chalcones found in the Chinese herbal medicine Gancao. First, their antioxidant mechanisms were investigated using four sets of colorimetric measurements in this study. Three sets were performed in aqueous solution, namely Cu2+-reduction, Fe3+-reduction, and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-scavenging measurements, while 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•)-scavenging colori...
22 CitationsSource