Jie-wen Wang
Shenyang Pharmaceutical University
PharmacodynamicsPharmacokineticsNuclear chemistryAbsorption (skin)SolubilityBioavailabilityChemistryApoptosisIn vitroIn vivoHair lossCedrolAcetic acidIrritationCirrhosisGynostemma pentaphyllumMinoxidilEthyl acetateEthanolFibrosisAcetoneCarrageenanHepatic fibrosisPromotion effectHair growthTraditional medicineSignal transductionProtein kinase BPI3K/AKT/mTOR pathwayPharmacology
Publications 4
#1Yumeng ZhangH-Index: 4
Last. Yuqing ZhaoH-Index: 16
view all 7 authors...
Hepatic fibrosis would develop into cirrhosis or cancer without treating. Hence, it is necessary to study the mechanism and prevention methods for hepatic fibrosis. Gynostemma pentaphyllum is a traditional medicinal material with a high medicinal and health value. In this study, nineteen compounds obtained from G. pentaphyllum were qualitative and quantitative by HPLC-FT-ICR MS and HPLC-UV, respectively. Among them, the total content of 19 gypenosides accurately quantified reaches 72.21 mg/g and...
Last. Yuqing ZhaoH-Index: 16
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As the main component of Platycladus orientalis, cedrol has known germinal activity. A range of cedrol formulations have been developed to prevent hair-loss, but compliance remains key issues. In this study, we prepared cedrol nanoemulsion (CE-NE) and determined the particle size and PDI (polydispersion coefficient), investigated the hair growth activity and studied the bioavailability in vitro and in vivo. Results showed that the average particle size of CE-NE is 14.26 ± 0.16 nm, and the PDI va...
#1Jie-wen Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Shan-Shan Chen (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Alternate forms of drug crystals display different physicochemical properties. These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics. It is therefore important to compare the crystal forms of cedrol to obtain optimal anti-inflammatory and analgesic effects. This study, for the first time, obtained and reports three novel forms (I-III) of cedrol polymorphs. The three forms of cedrol were recrystallized from seven...
6 CitationsSource
#1Yan Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Jie-wen Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 6 authors...
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. However, the use of cedrol has been limited by application-related issues, such as poor water solubility and volatile features. Therefore, the present study developed a cream formulation of cedrol and evaluated various physicochemical parameters of the prepared cream. The optimized cedrol cream was selected after orthogonal tests and determined further. The dermatopharmacokinetics were studied to investigat...
4 CitationsSource