Jessica Wappler
CellPhagocytosisIntrinsic apoptosisProinflammatory cytokineCell typeApoptosisInflammationAmphiregulinMonocyteTissue homeostasisProgrammed cell deathCancer researchMAPK/ERK pathwayFas ligandMedicineImmune system
2Publications
2H-index
6Citations
Publications 2
Newest
#1Christopher Platen (Boston Children's Hospital)H-Index: 4
#2Stephan Dreschers (Boston Children's Hospital)H-Index: 7
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 7 authors...
Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphireg...
Source
#1Christopher Platen (Boston Children's Hospital)H-Index: 4
#2Stephan Dreschers (Boston Children's Hospital)H-Index: 7
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 5 authors...
Neonates are highly susceptible to microbial infections which is partially attributable to fundamental phenotypic and functional differences between effector cells of the adult and neonatal immune system. The resolution of the inflammation is essential to return to tissue homeostasis, but given that various neonatal diseases, such as periventricular leukomalacia, necrotizing enterocolitis, or bronchopulmonary dysplasia, are characterized by sustained inflammation, newborns seem predisposed to a ...
Source
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