Zhian Chen
Southern Medical University
Conjugated systemMicelleDrug resistanceCancerBiophysicsMitochondrial permeability transition poreGene deliverymicroRNACellPhotothermal therapyChemistryApoptosisMaterials scienceEffluxAutophagySericinIn vivoPaclitaxelVitamin B12Drug deliveryPhotodynamic therapyEndocytosisMitochondrionCytochrome cMitochondrial respiratory chainReactive oxygen speciesCancer researchTransfectionFlow cytometryBiochemistryCarcinogenesisCell growthClone (cell biology)MedicineInner mitochondrial membraneCell biologyCancer cellPharmacologyCaspaseCytosol
6Publications
2H-index
29Citations
Publications 6
Newest
#1Weihong Guo (Southern Medical University)H-Index: 6
#2Zhian Chen (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 9 authors...
Background Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead to drug resistance by pumping PTX out of GC cells. Consequently, it might be a hopeful way to combat drug resistance by inhibiting the out-pumping function of P-gp. Results In this study, we developed a drug delivery system incorporating PTX onto polyethylene glycol (PEG)-modified and oxidized sodium alginate (OSA)-functionalized graphene oxide (GO) nan...
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#1Zhian Chen (Southern Medical University)H-Index: 2
#2Yanrui Liang (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 16 authors...
Among various methods, the use of targeting nucleic acid therapy is a promising method for inhibiting gastric cancer (GC) cells' rapid growth and metastasis abilities. In this study, vitamin B12-labeled poly (d,l-lactide-co-glycolide) and polyethylene glycol nanoparticles (PLGA-PEG-VB12 NPs) were developed for microRNAs-532-3p mimics incorporating as targeting gene delivery systems (miR-532-3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. The ...
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#1Weihong Guo (Southern Medical University)H-Index: 6
#2Zhian Chen (Southern Medical University)H-Index: 2
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 15 authors...
CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, as near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic effect (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric cancer (GC) cells’ mitochondrial damage, remained unclear. Moreover, theranostic efficiency of HMON@CuS might be well improved by applying multi-modal imaging, which cou...
2 CitationsSource
#1Weihong Guo (Southern Medical University)H-Index: 6
#2Lizhi Deng (SYSU: Sun Yat-sen University)H-Index: 3
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 13 authors...
AIM: Our previous research has introduced sericin micelles to reverse drug resistance. However, these micelles could not selectively bind to gastric cancer (GC) cells. We developed vitamin B12 (VB12) conjugated sericin micelles for targeted GC therapy. MATERIALS & METHODS: We used VB12, sericin, synthetic poly(γ-benzyl-L-glutamate) (PBLG) and paclitaxel (PTX) to develop VB12-conjugated and PTX-loaded micelles (VB12-sericin-PBLG-PTX). Then we explored their physicochemical properties, cellular up...
9 CitationsSource
#1Weihong Guo (Southern Medical University)H-Index: 6
#2Jiang Yu (Southern Medical University)H-Index: 27
Last. Yanfeng Hu (Southern Medical University)H-Index: 22
view all 13 authors...
Although paclitaxel (PTX) is a promising front-line agent for gastric cancer (GC), its hydrophobic characteristics and ineffective cancer site access have limited its clinical applications. Previously, we have introduced nanosized drug delivery systems based on sericin micelles, to reverse drug resistance. However, these micelles lacked the ability to selectively bind and directly affect cancer cells. In general, vitamin B12 (VB12) is highly required by malignant tumors, while its related recept...
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#1Weihong Guo (Southern Medical University)H-Index: 6
#2Zhaoyu Chen (Southern Medical University)H-Index: 3
Last. Yanfeng HuH-Index: 22
view all 11 authors...
Background: RAB3A-interacting protein (Rab3IP) is known to be involved in cancer; however, its function during the proliferation of gastric cancer (GC) cells remains unknown. Therefore, this study aimed to explore the potential function of Rab3IP in GC. Methods: The expression of Rab3IP and its clinical pathology value were determined by quantitative real-time PCR and immunohistochemistry. Rab3IP (knockdown and overexpression) and light chain 3 (LC3) lentiviruses were transfected into GC cells, ...
15 CitationsSource