Yurong Fu
Jilin University
CytotoxicityCancerASK1Unfolded protein responseCellGene expressionMolecular biologyEndoplasmic reticulumProinflammatory cytokineAndrologyFloraReceptorTumor necrosis factor alphaChemistryApoptosisAdverse effectSuperoxide dismutaseSOD2Mechanism of actionOxidative stressKEAP1ResveratrolInflammationZearalenoneAntioxidantCurcuminMalondialdehydeLipopolysaccharideFusariumATF6Cell damageZinc protoporphyrinCell cycleBeneficial bacteriaMucosal immunityDietary fibreWeaned pigletsProgrammed cell deathFood sciencePomaceAflatoxinReactive oxygen speciesCancer researchNecrosisViability assayGlutathioneFlow cytometryWineOxidative phosphorylationCell growthSignal transductionHsp70IntracellularMycotoxinBiologyMicrobiologyMitosisCell biologyCancer cell
10Publications
4H-index
44Citations
Publications 10
Newest
#1Ruihua LiH-Index: 4
#2Hengtong FangH-Index: 4
Last. Jing ZhangH-Index: 5
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Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. The purpose of this study is to investigate whether CUR can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by LPS and its underlying molecular mechanism. ...
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#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Yue Tian (JLU: Jilin University)
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Zearalenone (ZEA) is a mycotoxin of the Fusarium genus that can cause endoplasmic reticulum (ER) stress and Apoptosis in bovine mammary epithelial cells (MAC-T). Polydatin (PD), a glycoside purified from Polygonum cuspidatum, has antioxidant properties. This study aimed to explore whether PD can alleviate ZEA-induced damage on bovine mammary epithelial cells (MAC-T). We found that incasing the concentration of ZEA (0, 7.5, 15, 30, 60, 90, 120, and 240 μM) gradually decreased the cell viability. ...
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#1Ruihua LiH-Index: 4
#2Jing ZhangH-Index: 5
Last. Hao YuH-Index: 8
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Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. Curcumin (CUR), a well-known cancer inhibitor, significantly inhibits the viability of breast cancer cells. Through transcriptomic analysis and flow cytometry experiments, it was found that after 48 hours of treatment of breast cancer cells at its half maximal inhibitory concentration (IC50), curcumin suppressed the viability of cancer cells via induction of ferroptotic death. Use of the ...
3 CitationsSource
#1Rui Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Grape pomace (GP) is an abundant by-product from wine production and is rich in phenolic compounds, unsaturated fatty acids, dietary fibre and beneficial bacteria. In this study, weaned piglets were fed a basic diet supplemented with 5% GP for 4 weeks. Compared with those in the control (CON) group, it was found that the proportion of Lactobacillus delbrueckii, Olsenella umbonata and Selenomonas bovis in the caecum and the villus height and villus height/crypt depth ratio (VCR) of the jejunum we...
1 CitationsSource
#1Jing ZhangH-Index: 5
#2Xin WangH-Index: 4
Last. Hao YuH-Index: 8
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1 CitationsSource
#1Xin Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Abstract Mounting evidence has shown that zearalenone (ZEA) can have toxic effects on the intestinal epithelial cells (IECs) of mammals and humans, but the mechanism of ZEA-induced toxicity on IECs is unclear. The aim of this study was to reveal the mechanism of action of ZEA on intestinal epithelial cells via RNA-seq technology. We measured the effects of ZEA on the viability and lactate dehydrogenase (LDH) activity of the pig intestinal epithelial cell line J2 (IPEC-J2). The results showed ZEA...
4 CitationsSource
#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 14 authors...
ABSTRACT Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary epithelial cells (MAC-T) from dairy cows were investigated. The cells were treated with different concentrations of ZEA to evaluate the effect of the toxin on cell viability, intracellular reactive oxygen species (ROS) concentrations, mitochondria...
5 CitationsSource
#1Junmei Wang (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 16 authors...
Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium graminearum. It is one of the most common feed contaminants that poses a serious threat to the health and performance of dairy cows. This study investigated the in vitro cytotoxicity of DON on bovine mammary epithelial cells (MAC-T). DON at different concentrations (0.25, 0.3, 0.5, 0.8, 1 or 2 μg/ml) inhibited the growth of MAC-T cells after 24 hr of exposure (p < .001). DON at 0.25 μg/ml increased lactate dehydrogenase (L...
7 CitationsSource
#1Yongfeng Zhou (JLU: Jilin University)H-Index: 5
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
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Abstract Aflatoxins are widely occurring food contaminants that are particularly harmful to dairy products and cows. The plant polyphenol resveratrol has been reported to have a good effect on increasing the resistance of cells toward toxins. Therefore, we measured the effects of aflatoxin B1 and resveratrol on the viability of the MAC-T cow mammary epithelial cell line. The appropriate treatment concentrations were assayed (12.81 μM aflatoxin B1 and 43.81 μM resveratrol) to verify the protectiv...
11 CitationsSource
#1Xin Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 12 authors...
ABSTRACTZearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the effects of short-term ZEA exposure on mucosal immunity and the microecological balance of the intestine. We found that the morphological structure of the intestinal mucosa in mice was severely...
10 CitationsSource