Cecilia Nasso
CancerInternal medicineOncologyInfection controlRandomized controlled trialStage (cooking)Prospective cohort studyAdverse effectHormone receptorExemestaneMetastatic breast cancerAromataseSteatosisChemotherapyTamoxifenInsulin resistancePrioritizationAdjuvantSirolimusFatty liverEverolimusTrastuzumabBody mass indexOverweightProgression-free survivalPertuzumabPopulation2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Advanced breastTumor responseNorthern italyEndocrine therapyEarly breast cancerStage at diagnosisIncidence (epidemiology)Endocrine systemObesityBreast cancerMedicineGastroenterologyMeta-analysis
Publications 8
Introduction null In the last decade, there have been substantial changes in the management of metastatic renal cell carcinoma (mRCC) with combined regimens with immune checkpoint inhibitors (ICI) replacing targeted therapies. These combined regimens include the combination of cabozantinib plus nivolumab. null Areas covered null Here, we provide an overview of clinical trials evaluating the combination of cabozantinib and nivolumab and the current clinical data on mechanism of action, pharmacoki...
#1Angela Toss (University of Modena and Reggio Emilia)H-Index: 16
#2Chrystel IscaH-Index: 3
Last. Luca MoscettiH-Index: 20
view all 17 authors...
Introduction The present analysis aims to evaluate the consequences of a 2-month interruption of mammographic screening on breast cancer (BC) stage at diagnosis and upfront treatments in a region of Northern Italy highly affected by the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) virus. Methods This retrospective single-institution analysis compared the clinical pathological characteristics of BC diagnosed between May 2020 and July 2020, after a 2-month screening interru...
8 CitationsSource
Background Fat tissue is strongly involved in BC tumorigenesis inducing insulin resistance, chronic inflammation and hormonal changes. Computed tomography (CT) imaging instead of body mass index (BMI) gives a reliable measure of skeletal muscle mass and body fat distribution. The impact of body composition parameters (BCPs) on chemosensitivity is still debated. We examined the associations between BCPs and tumor response to neoadjuvant chemotherapy (NC) in patients treated for operable breast ca...
9 CitationsSource
#1Claudia OmariniH-Index: 10
#2Federico PiacentiniH-Index: 20
Last. Luca MoscettiH-Index: 20
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1046Background: Combined endocrine approaches have been widely investigated as first-line treatment in hormone receptors positive metastatic breast cancer. In particular, multiple randomized trials...
1 CitationsSource
#1Patrizia PalumboH-Index: 1
#2Stefano DraisciH-Index: 1
Last. Claudia OmariniH-Index: 10
view all 14 authors...
Background. Everolimus has been shown to overcome endocrine resistance in hormone receptor positive advanced breast cancer patients. Predictive biomarkers of everolimus efficacy have been investigated in primary breast cancer tissue without finding univocal results. The goal of this study was to investigate the mutational burden in the metastatic site of endocrine-resistant tumors treated with everolimus plus exemestane. Patients and Methods. Mass Array Sequenom platform was used to analyse gene...
4 CitationsSource