Chih Min Tang
University of California, San Diego
Genetically modified mousePathologyAntibodyMonoclonalStromal cellPlatelet-derived growth factor receptorImmunohistochemistryIn vivoGrowth factor receptorGiSTPDGFCTumor microenvironmentStromal tumorHedgehogCrenolanibMetastasisPTCH1GLI1Surgical oncologySonidegibOncogeneCrenolanib BesylatePTCH1 GeneCell killingImatinib mesylatePDGFRATyrosine kinaseCancer researchCarcinogenesisFluorescence-lifetime imaging microscopyMedicinePDGFRBParacrine signallingBiologyHedgehog signaling pathway
5Publications
4H-index
86Citations
Publications 5
Newest
#1Hyunho Yoon (UCSD: University of California, San Diego)H-Index: 3
#2Chih-Min Tang (UCSD: University of California, San Diego)H-Index: 7
Last. Jason K. Sicklick (UCSD: University of California, San Diego)H-Index: 33
view all 22 authors...
Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic targets in GIST by investigating the tumor microenvironment. Here, we identified a paracrine signaling network by which cancer-associated fibroblasts (CAFs) drive GIST growth and metastasis. Specifically, CAFs isolated from human tumors were found to produce high levels of platelet-derived ...
2 CitationsSource
#1Sudeep Banerjee (UCSD: University of California, San Diego)H-Index: 6
#2Christopher L. Corless (OHSU: Oregon Health & Science University)H-Index: 107
Last. Jason K. Sicklick (UCSD: University of California, San Diego)H-Index: 33
view all 10 authors...
Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It was recently demonstrated that approximately one-third of PF have activation of the GLI1 oncogene, a transcription factor in the hedgehog (Hh) pathway, via a MALAT1-GLI1 fusion protein or GLI1 up-regulation. Despite this discovery, the biology of most PFs remains unknown. Next generation sequ...
5 CitationsSource
#1Chih Min Tang (UCSD: University of California, San Diego)H-Index: 4
#2Tracy E. Lee (UCSD: University of California, San Diego)H-Index: 2
Last. Jason K. Sicklick (UCSD: University of California, San Diego)H-Index: 33
view all 19 authors...
// Chih-Min Tang 1,* , Tracy E. Lee 1,* , Sabriya A. Syed 2,3,* , Adam M. Burgoyne 4 , Stephanie Y. Leonard 1 , Fei Gao 2 , Jonathan C. Chan 1 , Eileen Shi 5 , Juliann Chmielecki 6 , Deborah Morosini 6 , Kai Wang 6 , Jeffrey S. Ross 6 , Michael L. Kendrick 7 , Michael R. Bardsley 2 , Martina De Siena 1 , Junhao Mao 8 , Olivier Harismendy 9 , Tamas Ordog 2,10,* and Jason K. Sicklick 1,5,* 1 Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, ...
17 CitationsSource
#1Yujiro Hayashi (Mayo Clinic)H-Index: 26
#2Michael R. Bardsley (Mayo Clinic)H-Index: 12
Last. Tamas Ordog (Mayo Clinic)H-Index: 41
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Background & Aims In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is predominantly expressed by interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor-α (PDGFRA) polypeptide is expressed by so-called fibroblast-like cells. KIT and PDGFRA have been reported to be coexpressed in ICC precursors and gastrointestinal stromal tumors (GISTs), which originate from the ICC lineage. PDGFRA signaling has been proposed to stimulate grow...
38 CitationsSource
#1Cristina A. Metildi (UC: University of California)H-Index: 15
#1Cristina A. Metildi (UC: University of California)H-Index: 1
Last. Jason K. Sicklick (UC: University of California)H-Index: 33
view all 9 authors...
Background Gastrointestinal stromal tumors (GISTs) are frequently characterized by KIT overexpression. Tumor-free margins and complete cytoreduction of disease are mainstays of treatment. We hypothesized that fluorescently labeled anti-KIT antibodies can label GIST in vivo.
23 CitationsSource