Fang Feng
China Pharmaceutical University
PharmacokineticsAnalytical chemistryDetection limitMass spectrometryHigh-performance liquid chromatographyChemistryTraditional Chinese medicineDecoctionMetabolomicsDerivatizationAlcoholic liver diseaseChlorideAnthraquinoneAnthraquinonesGrapheneReagentChromatographyElectrochemistryBiochemistryLiquid chromatography–mass spectrometryMedicinePharmacology
52Publications
17H-index
550Citations
Publications 42
Newest
#1Xiao-Lei Zhang (CPU: China Pharmaceutical University)H-Index: 2
#2Ji-Lan Qi (CPU: China Pharmaceutical University)
Last. Gongjun Yang (CPU: China Pharmaceutical University)H-Index: 7
view all 4 authors...
Abstract A novel molecularly imprinted electrochemiluminescene (ECL) sensor was fabricated for the detection of ethosuximide. The new Ru(pby)32+@N-GQDs (tris(2,2′-bipyridyl) ruthenium(II)@nitrogen doped graphene quantum dots) nanocomposite was synthesized by electrostatic interaction between Ru(pby)32+ and N-GQDs, which showed excellent and stable ECL properties. And then dopamine as functional monomer and ethosuximide as template molecule were co-polymerized by hydrogen bonding on the surface o...
1 CitationsSource
#1Qianqian Zhang (CPU: China Pharmaceutical University)H-Index: 1
#2Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
Abstract In recent years, depression occurs frequently. Given the long duration of the disease and the high risk of recurrence, the treatment of depression requires long-term medication. Zhi-Zi-Hou-Po Decoction (ZZHPD) has been used in clinical treatment of depression and related diseases for many years, and the potential toxic damage caused by its long-term use has gradually emerged. Existing research methods that expose toxicity by a one-time administration of large doses cannot provide a refe...
3 CitationsSource
#1Xiaotong Li (CPU: China Pharmaceutical University)H-Index: 2
#2Yanchun Wang (YZU: Yangzhou University)H-Index: 1
Last. Gongjun Yang (CPU: China Pharmaceutical University)H-Index: 7
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An electrochemical immunosensor for the determination of porcine epidemic diarrhea virus (PEDV) is described. It was manufactured by using gold nanoparticles/molybdenum disulfide/reduced graphene oxide nanocomposites modified on the surface of a glassy carbon electrode (GCE). The independently developed monoclonal antibody of PEDV-2C11 was immobilized on the modified electrode at site of gold nanoparticles provided in the nanocomposites. The concentration of PEDV was quantified by measuring the ...
7 CitationsSource
#1Qing Hu (CPU: China Pharmaceutical University)H-Index: 2
#2Xixi Li (CPU: China Pharmaceutical University)H-Index: 2
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
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AbstractZhi-Zi-Da-Huang decoction (ZZDHD) has been acknowledged with striking therapeutic effects for hepatobiliary disorders in the history of China. As decoctions are usually administrated orally, intestinal absorption, the prerequisite task of exerting therapeutic effects, is of utmost significance for screening potential active compounds and understanding the mechanism of drug action.In this work, an in vitro–in silico–in vivo strategy based on HPLC-DAD-ESI-TOF/MS was adopted for precisely p...
3 CitationsSource
#1Xiao-Lei Zhang (CPU: China Pharmaceutical University)H-Index: 2
#2Xue Li (CPU: China Pharmaceutical University)H-Index: 1
Last. Gongjun Yang (CPU: China Pharmaceutical University)H-Index: 7
view all 6 authors...
Abstract The Au nanoclusters@graphene quantum dots nanocomposite as an electrochemiluminescence (ECL) luminophore was synthesized through amide coupling reaction between Au nanoclusters (Au NCs) and graphene quantum dots (GQDs). The ECL intensity of the as-prepared Au NCs@GQDs was enhanced for 2.6-fold compared with that of Au NCs or 40-fold compared with that of GQDs, which was due to the ECL resonance energy transfer between GQDs as a donor and Au NCs as an acceptor, and excellent electrical c...
17 CitationsSource
#1Xiaoyan Wang (CPU: China Pharmaceutical University)H-Index: 1
#2Weiyang Shen (CPU: China Pharmaceutical University)H-Index: 1
Last. Gongjun Yang (CPU: China Pharmaceutical University)H-Index: 3
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AbstractA novel method for the indirect electrochemical determination of ribavirin based on boronic acid-diol recognition was developed using the platform as the sensing element. The device was constructed using a 3-aminophenylboronic acid (APBA)-electrochemically reduced graphene oxide (ERGO) modified electrode. When the electrode was immersed in a solution of ribavirin, complexation of boronic acid groups of APBA with ribavirin occurred at the surface of the electrode and simultaneously caused...
2 CitationsSource
#1Miao Wang (CPU: China Pharmaceutical University)H-Index: 1
#2Qing Hu (CPU: China Pharmaceutical University)H-Index: 2
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
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Abstract1. Zhi–Zi–Da–Huang decoction (ZZDHD) has been widely used for the treatment of alcoholic jaundice, alcoholic liver disease, and acute hepatitis in China for thousands of years. Conventionally decoctions are administered orally, after which the metabolism caused by the enzymes in intestinal bacteria may influence significantly on the curative effects or toxicity.2. In this work, the comprehensive metabolic process of ZZDHD in intestinal bacteria was investigated reliably using high-resolu...
11 CitationsSource
#1Guoxue Zhu (CPU: China Pharmaceutical University)
#2Yiling Chen (CPU: China Pharmaceutical University)
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
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Da-Huang-Xiao-Shi decoction (DHXSD) is a representative formula for treating jaundice and could have bright prospects owing to its liver protecting effects. DHXSD might synthetically result in a change in the metabolic profiles of cholestasis rats compared with that of normal rats after oral administration. Metabolic profiling analysis has gained significant attention ever since the field of metabolomics began to develop. In this study, a highly sensitive, rapid and high chromatographic resoluti...
Source
#1Guoxue Zhu (CPU: China Pharmaceutical University)H-Index: 1
#2Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
Cortex Phellodendri is derived from two species of Phellodendron amurense Rupr. and Phellodendron chinense Schneid. Traditionally, the two species are utilized interchangeably under the name of “huangbo” in the clinic because they are believed to share the same clinical efficacy. However, the chemical analysis in vitro couldn't directly reflect the pharmacological effects. Therefore, whether the constituents could be absorbed into the blood becomes the uppermost problem to account for the clinic...
2 CitationsSource
#1Dan Wang (CPU: China Pharmaceutical University)H-Index: 1
#2Qingshui ShiH-Index: 3
Last. Fang Feng (CPU: China Pharmaceutical University)H-Index: 17
view all 3 authors...
Da-Huang-Xiao-Shi decoction has been used to treat damp-heat jaundice for centuries in China. However, the absorbed components of the decoction and their related metabolites are little known till now. In this work, an integrative strategy based on liquid chromatography coupled with mass spectrometry (time-of-flight/triple-quadruple tandem) was adopted to effectively identify the prototypes and their metabolites and to speculate the possible transformation pathways among these compounds. Using pa...
6 CitationsSource