Cong Cao
China-Japan Friendship Hospital
Induced pluripotent stem cellCollagen receptorStem cell transplantation for articular cartilage repairClinical uses of mesenchymal stem cellsBone remodelingInduced stem cellsChemistryMesenchymal stem cellAdult stem cellBasic fibroblast growth factorKeratinocyte growth factorWound healingStem cellBone Marrow Stem CellSchwann cell differentiationSchwann cell proliferationBone regenerationBone morphogenetic protein 2MedicineCell biology
Publications 6
#1Qingqing Wu (CQMU: Chongqing Medical University)H-Index: 5
#2Bo Yang (Capital Medical University)H-Index: 5
Last. Yi Man (Sichuan University)H-Index: 19
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Abstract Induced pluripotent stem cells (iPSCs) are regarded as a new cell source for regenerative medicine. Recent advances in tissue engineering have brought to light the therapeutic application of induced pluripotent stem cells (iPSCs) in bone defect repair. However, a safe and efficient way to differentiate iPSCs into osteogenic lineage remains to be a major challenge. Here we describe an approach using anti-BMP2 antibodies (Abs) to mediate osteogenic differentiation of iPSC-derived mesenchy...
8 CitationsSource
#1Yili Qu (Sichuan University)H-Index: 16
#2Cong Cao (China-Japan Friendship Hospital)H-Index: 5
Last. Yi Man (Sichuan University)H-Index: 19
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: The major challenges associated with skin regeneration can include hindered vascularization and an insufficient degree of epithelization. In view of the complexity of these processes and the control signals on which they depend, one possible solution to these limitations could be simulating normal skin development and wound repair via the exogenous delivery of multiple cytokines. Here, we report the use of keratinocyte growth factor (KGF or FGF-7) and basic fibroblast growth factor (bFGF or FG...
15 CitationsSource
#1Chenyu Chu (Sichuan University)H-Index: 11
#2Deng Jia (Sichuan University)H-Index: 6
Last. Yili Qu (Sichuan University)H-Index: 16
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Collagen is an essential component of the extracellular matrix (ECM) and is a suitable material for nerve repair during tissue remodeling for fracture repair. Epigallocatechin-3-gallate (EGCG), an extract of green tea, shows various biological activities that are beneficial to nerve repair. Here, we developed modified collagen containing different concentrations of EGCG (0.0064%, 0.064%, and 0.64%, resp.) to induce Schwann cell proliferation and differentiation. Cell Counting Kit-8 test, live/de...
6 CitationsSource
#1Qingqing Wu (Sichuan University)H-Index: 5
#2Bo Yang (Sichuan University)H-Index: 5
Last. Ping Gong (Sichuan University)H-Index: 17
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Aging is associated with peripheral nerve degradation and bone destruction. The aim of the study is to elucidate the influence of sensory denervation on bone metabolism in different age groups by establishing a modified unilateral inferior alveolar nerve transection (IANT) model. The rats, divided into young, middle-aged and aged group, were sacrificed at 1, 2, 4 and 8 weeks after right IANT. The histological changes of mandibles were analyzed by fluorescent double labeling, micro-CT, HE, TRAP a...
7 CitationsSource
#1Qingqing Wu (Sichuan University)H-Index: 5
#2Bo Yang (Sichuan University)H-Index: 5
Last. Ping WangH-Index: 19
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Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells using defined transcription factors, are regarded as a promising cell source for tissue engineering. For the purpose of bone tissue regeneration, efficient in vitro differentiation of iPSCs into downstream cells, such as mesenchymal stem cells (MSCs), osteoblasts, or osteocyte-like cells, before use is necessary to limit undesired tumorogenesis associated with the pluripotency of iPSCs. Until recently numerous techniqu...
25 CitationsSource
#1Hongling Li (Sichuan University)H-Index: 1
#1Frances R Henshaw (USYD: University of Sydney)H-Index: 4
Last. Stephen M. Twigg (RPA: Royal Prince Alfred Hospital)H-Index: 59
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A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Inde...
1 CitationsSource