Caroline Mann
Goethe University Frankfurt
NeuroanatomyAnatomyDopamine receptorInternal medicineEndocrinologyDopaminergicNeuropsychologyBrain morphometryDiffusion MRIPsychologyCytoarchitectureNeurologyNeuroscienceChemistryAutismPrecentral gyrusContrast (vision)Folding (DSP implementation)Spatial distributionCortex (anatomy)Transcranial direct-current stimulationGrey matterNeurotypicalAutism spectrum disorderPosterior cingulateNeurodevelopmental disorderPsychosisDown syndromeNeuropathologyLevodopaDorsolateral prefrontal cortexAttention deficit hyperactivity disorderGyrificationWhite matterAutistic symptomsWHITE MATTER TISSUEGenetic ConditionGynecologyNeural activitySpatial similarityBrain tissueBrain anatomyStructural magnetic resonance imagingDeletion syndromeStructural imagingAufmerksamkeitsdefizit hyperaktivitatsstorungCortical volume22q11 2 microdeletionRegional differencesTypically developingClinical phenotypeCortex (botany)Nuclear magnetic resonanceDopamineAudiologyNeuroimagingContrast (statistics)BioinformaticsBoundary (topology)Resting state fMRIText miningMedicineSchizophreniaBiologyFractional anisotropyFrustum
12Publications
3H-index
23Citations
Publications 12
Newest
#1Caroline Mann (Goethe University Frankfurt)H-Index: 3
#2Tim Schäfer (Goethe University Frankfurt)H-Index: 4
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 13 authors...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer-specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and 92 adult individuals with ASD (aged 18-52 years), we examined volumetric gradients by quantifying the degree to which CV is weighted from...
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#1Anke Bletsch (Goethe University Frankfurt)H-Index: 3
#2Tim Schäfer (Goethe University Frankfurt)H-Index: 4
Last. Crispian WilsonH-Index: 2
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Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray-white matter (GWM) boundary, represent a crucial feature of ASD. However, no research has yet characterized the GWM boundary in ASD based on measures of di...
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#1Tim Schäfer (Goethe University Frankfurt)H-Index: 4
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 7 authors...
Zusammenfassung. Theoretischer Hintergrund: Autismus-Spektrum-Storung (ASS) ist eine neuronale Entwicklungsstorung und tritt haufig gemeinsam mit der Aufmerksamkeitsdefizit-/Hyperaktivitatsstorung ...
1 CitationsSource
#1Maria Gudbrandsen ('KCL': King's College London)H-Index: 11
#2Eileen Daly ('KCL': King's College London)H-Index: 65
Last. Christine Ecker ('KCL': King's College London)H-Index: 43
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22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion in humans, with a heterogenous clinical presentation including medical, behavioural and psychiatric conditions. Previous neuroimaging studies examining the neuroanatomical underpinnings of 22q11.2DS show alterations in cortical volume (CV), cortical thickness (CT) and surface area (SA). The aim of this study was to identify (1) the spatially distributed networks of differences in CT and SA in 22q11.2DS compared to controls, (...
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#1Maria Gudbrandsen ('KCL': King's College London)H-Index: 11
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 13 authors...
: 22q11.2 deletion syndrome (22q11.2DS) is a genetic condition accompanied by a range of psychiatric manifestations, including autism spectrum disorder (ASD). It remains unknown, however, whether these symptoms are mediated by the same or distinct neural mechanisms as in idiopathic ASD. Here, we examined differences in lGI associated with ASD in 50 individuals with 22q11.2DS (n = 25 with ASD, n = 25 without ASD) and 81 individuals without 22q11.2DS (n = 40 with ASD, n = 41 typically developing c...
3 CitationsSource
#1Maria Gudbrandsen ('KCL': King's College London)H-Index: 11
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 13 authors...
Source
#1Maria Gudbrandsen ('KCL': King's College London)H-Index: 11
#2Anke Bletsch (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 13 authors...
A crucial step to understanding the mechanistic underpinnings of autism spectrum disorder (ASD), is to examine if the biological underpinnings of ASD in genetic high-risk conditions, like 22q11.2 deletion syndrome (22q11.2DS), are similar to those in idiopathic illness. This study aimed to examine if ASD symptomatology in 22q11.2DS is underpinned by the same—or distinct—neural systems that mediate these symptoms in non-deletion carriers. We examined vertex-wise estimates of cortical volume (CV),...
2 CitationsSource
#1Maria GudbrandsenH-Index: 11
#2Anke BletschH-Index: 3
Last. Carrie E. BeardenH-Index: 79
view all 13 authors...
Source
#1Benjamin Meyer (University of Mainz)H-Index: 10
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Raffael Kalisch (University of Mainz)H-Index: 32
view all 10 authors...
Dopamine dysfunction is associated with a wide range of neuropsychiatric disorders commonly treated pharmacologically or invasively. Recent studies provide evidence for a nonpharmacological and noninvasive alternative that allows similar manipulation of the dopaminergic system: transcranial direct current stimulation (tDCS). In rodents, tDCS has been shown to increase neural activity in subcortical parts of the dopaminergic system and recent studies in humans provide evidence that tDCS over pref...
6 CitationsSource
#1Anke Bletsch (Goethe University Frankfurt)H-Index: 3
#2Caroline Mann (Goethe University Frankfurt)H-Index: 3
Last. Christine Ecker (Goethe University Frankfurt)H-Index: 43
view all 7 authors...
: Increased cortical thickness (CT) has been reported in Down syndrome (DS) during childhood and adolescence, but it remains unclear, which components of the neural architecture underpin these increases and if CT remains altered in adults. Among other factors, differences in CT measures could be driven by reduced tissue contrast between grey and white matter (GWC), which has been reported in neurodegenerative disorders, such as Alzheimer's disease. Using structural magnetic resonance imaging, we...
5 CitationsSource