Dimitrios Andrikos
University of Duisburg-Essen
HaematopoiesisInterquartile rangeInternal medicineMann–Whitney U testObstetricsImmunoglobulin class switchingCase-control studyOdds ratioB-cell receptorCell adhesion moleculeAndrologyRetrospective cohort studySubgroup analysisNaive B cellImmunologyStimulationT cellPlacentaPreeclampsiaCarcinoembryonic antigenImmune toleranceB cellPregnancyImmunityMemory B cellImmune dysregulationCord bloodImmune tolerance in pregnancyBlood serumIn patientFirst trimesterPhysiologybreakpoint cluster regionGestationEarly pregnancy factorMedicineBiomarker (medicine)Area under the curveBiologyImmune systemGastroenterology
8Publications
2H-index
14Citations
Publications 9
Newest
#2Dimitrios AndrikosH-Index: 2
Last. A Köninger (University Hospital Regensburg)
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PURPOSE The study aimed to assess the course of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in pregnant women with fetal growth restriction (FGR) and to evaluate potential associations between the sFlt-1/PlGF ratio and feto-maternal Doppler parameters, fetal biometric measurements and the time between study inclusion and birth ("time to delivery"). METHODS This was a retrospective longitudinal single center study including 52 FGR cases. The serum levels o...
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#1Bettina Budeus (University of Duisburg-Essen)H-Index: 8
#2Artur Kibler (University of Duisburg-Essen)H-Index: 1
Last. Taras Kreslavsky (Karolinska University Hospital)H-Index: 17
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Neonatal and infant immune responses are characterized by a limited capability to generate protective Ab titers and memory B cells as seen in adults. Multiple studies support an immature or even impaired character of umbilical cord blood (UCB) B cells themselves. In this study, we provide a comprehensive molecular and functional comparison of B cell subsets from UCB and adult peripheral blood. Most UCB B cells have a mature, naive B cell phenotype as seen in adults. The UCB Ig repertoire is high...
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#1Pawel MachH-Index: 10
#2Dimitrios AndrikosH-Index: 2
Last. Angela Köninger (University of Regensburg)H-Index: 11
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PROBLEM The aim of this study was to evaluate the sCEACAM1 concentrations in serum from patients in the first trimester who have a high risk for developing PE during pregnancy. METHOD OF THE STUDY Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) levels were determined with ELISA. The patients (n = 109) were divided into two groups: patients who have a high risk of developing PE early-onset and a control group. Patients who have a high risk of developing PE were then divided in...
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#2Dimitrios AndrikosH-Index: 2
Last. Angela KöningerH-Index: 11
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#1Dimitrios AndrikosH-Index: 2
Last. Pawel MachH-Index: 10
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Fur eine erfolgreiche Schwangerschaft wird eine adaquate Immuntoleranz vorausgesetzt. Eine gestorte Immuntoleranz fuhrt zur Plazentadysfunktion und demzufolge zu Schwangerschaftskomplikationen, wie einer Praeklampsie (PE) oder einer Wachstumsretardierung (IUGR). Man kann nach aktuellem Wissen durch das Ersttrimesterscreening fruhzeitig die Plazentadysfunktion bzw. die am meisten gefahrdeten Patientinnen identifizieren und durch Einnahme von Aspirin® (ASS) das Risiko fur fruhe plazentare Dysfunkt...
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#1Bettina Budeus (University of Duisburg-Essen)H-Index: 8
#2Artur Kibler (University of Duisburg-Essen)H-Index: 1
Last. Marc Seifert (University of Duisburg-Essen)H-Index: 17
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The human infant B cell system is considered premature or impaired. Here we show that neonates have mature and fully functional B cell subsets as seen in adults, albeit with distinct transcriptional programs providing accelerated responsiveness to T cell independent and T cell dependent stimulation and facilitated IgA class switching. Stimulation drives extensive differentiation into antibody secreting cells, thereby presumably limiting memory B cell formation. The neonatal Ig-repertoire is high...
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#1Alexandra GellhausH-Index: 19
#2Pawel MachH-Index: 10
Last. Angela KöningerH-Index: 11
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Introduction The successful outcome of pregnancy requires adequate immune tolerance. A lack of appropriate tolerance might cause placental dysfunction and pregnancy complications such as preeclampsia (PE). Members of the B7 family play an essential role in maintaining immune tolerance in pregnancy by effecting T cells. Objectives B7-H4 is responsible for the negative regulation of T-cell-mediated immune response and might play an important role in PE. We currently revealed that sB7-H4 is involve...
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#1Angela Köninger (University of Duisburg-Essen)H-Index: 11
#2A Enekwe (University of Duisburg-Essen)H-Index: 5
Last. Hans Dieplinger (Innsbruck Medical University)H-Index: 24
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Purpose Oxidative stress is involved in the pathogenesis of hypertensive disorders such as preeclampsia (PE) and associated with the human vitamin E-binding protein afamin. The aim of this study was, therefore, to analyse afamin in the first trimester of patients developing PE later in pregnancy and in control subjects without pregnancy complications.
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PROBLEM: B7-H4 negatively regulates T-cell-mediated immunity and might play an important role in preeclampsia (PE). Here, we have investigated the association between PE and maternal soluble B7-H4 (sB7-H4) serum levels and B7-H4 mRNA expression in the placenta. METHOD OF STUDY: Maternal serum levels of sB7-H4 were determined by enzyme-linked immunosorbent assay in women between 11 and 13 weeks' gestation with elevated risk for PE (n = 48) and women without elevated risk for PE (n = 47). In the t...
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