Bowen Yang
Guangzhou University of Chinese Medicine
CancerDownregulation and upregulationChemokineWnt signaling pathwayUnfolded protein responseIntegrin alpha MChemistryApoptosisGlycolysisAutophagyIn vivoMetastatic breast cancerTumor microenvironmentMammary tumorBetulinic acidXenotransplantationMetastasisBone marrowProstate cancerCaveolin 1Stem cellCateninCancer researchAbcg2Breast cancerAnaerobic glycolysisMedicineCancer cellCXCL1
22Publications
10H-index
232Citations
Publications 24
Newest
#1Jing Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Shengqi Wang (Guangzhou University of Chinese Medicine)H-Index: 14
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#9Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Abstract null null Background null : Metastasis is the most common lethal cause of breast cancer-related death. Recent studies have implied that autophagy is closely implicated in cancer metastasis. Therefore, it is of great significance to explore autophagy-related molecular targets involved in breast cancer metastasis and to develop therapeutic drugs null null null . Purpose null : This study was designed to investigate the anti-metastatic effects and autophagy regulatory mechanisms of the Aid...
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#3Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Background null Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for survival period prolongation and immune balance modulation. However, the underlying molecular mechanisms remain largely unknown. This study aimed to explore the antimetastatic effect and immunomodulatory function of a clinical formula Aiduqing (ADQ). null Methods null Naive CD4+...
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#10Zhiyu Wang (Guangzhou University of Chinese Medicine)
Background: Depression plays a significant role in mediating breast cancer recurrence and metastasis. However, a precise risk model is lacking to evaluate the potential effects of depression on breast cancer prognosis. In this study, we established a depression-related gene (DRG) signature that can predict overall survival (OS) and elucidated its correlation with pathological parameters and sensitivity to therapy in breast cancer. Methods: The model training and validation assays were based on t...
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#7Fengxue Zhang (Guangzhou University of Chinese Medicine)H-Index: 6
#8Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
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#1Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
As one of the most abundant immune cell populations in the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play important roles in multiple solid malignancies, including breast cancer, prostate cancer, liver cancer, lung cancer, ovarian cancer, gastric cancer, pancreatic cancer, and colorectal cancer. TAMs could contribute to carcinogenesis, neoangiogenesis, immune-suppressive TME remodeling, cancer chemoresistance, recurrence, and metastasis. Therefore, reprogramming of the im...
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#1Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Sanguisorba officinalis L. (SA) is a common herb for cancer treatment in the clinic, particularly during the consolidation phase to prevent occurrence or metastasis. Nevertheless, there are limited studies reporting the molecular mechanisms about its anti-metastatic function. It is well demonstrated that autophagy is one of the critical mechanisms accounting for metastasis and anti-cancer pharmacological actions of Chinese herbs. On the threshold, the regulatory effects and molecular mechanisms ...
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#9Zhiyu Wang (Peking Union Medical College)
Abstract Background Breast cancer is the most common malignancy in women and metastasis is the leading cause of breast cancer-related deaths. Our previous studies have shown that XIAOPI formula, a newly approved drug by the State Food and Drug Administration of China (SFDA), can dramatically inhibit breast cancer metastasis by modulating the tumor-associated macrophages/C-X-C motif chemokine ligand 1 (TAMs/CXCL1) pathway. However, the bioactive compound accounting for the anti-metastatic effect ...
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Depression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included. The results showed that depression was associated with cancer recurrence [1.24 (1.07, 1.43)], all-cause mortality [1.30 (1.23, 1.36)], and cancer-specific mortality [1.29 (1.11, 1.49)]. However, anx...
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