Xilin Wu
Queen Mary University of London
Transmembrane domainInternal medicineRadiologyEndocrinologySomatic cellMutantGap junctionCell adhesion moleculeRandomized controlled trialChemistryPrimary (chemistry)Radiofrequency ablationAldosteroneMenopauseGNAQPregnancyAdrenalectomyPrimary aldosteronismEndoscopic ultrasoundGNA11MedicineBiologyCell biology
18Publications
0Citations
Publications 19
Newest
Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations in APAs. Here we identified gain-of-function mutations in both CTNNB1 and GNA11 by whole-exome sequencing of 3/41 APAs. Further sequencing of known CTNNB1-mutant APAs led to a total of 16 of 27 (59%) with a somatic p.Gln209His, p.Gln209Pro or p.Gln20...
1 CitationsSource
#1Xilin Wu (QMUL: Queen Mary University of London)
#2Russell SenanayakeH-Index: 1
Last. William M DrakeH-Index: 29
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#1Xilin Wu (QMUL: Queen Mary University of London)
#2Russell Senanayake (University of Cambridge)H-Index: 2
Last. Alison Marker (University of Cambridge)H-Index: 9
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#1Junhua Zhou (QMUL: Queen Mary University of London)H-Index: 8
#2Sheerazed Boulkroun (University of Paris)H-Index: 4
Last. Morris J. Brown (QMUL: Queen Mary University of London)H-Index: 97
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#1Elena A.B. Azizan (UKM: National University of Malaysia)H-Index: 13
#2Kha Chin Long (UKM: National University of Malaysia)
Last. Morris J. Brown (QMUL: Queen Mary University of London)H-Index: 97
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#1Xilin Wu (QMUL: Queen Mary University of London)
#2Alexander Ney (UCL: University College London)H-Index: 1
Last. Morris J. Brown (QMUL: Queen Mary University of London)H-Index: 97
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#1Junhua Zhou (QMUL: Queen Mary University of London)H-Index: 8
#2Claudia P. Cabrera (QMUL: Queen Mary University of London)H-Index: 19
Last. Morris J. Brown (QMUL: Queen Mary University of London)H-Index: 97
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#1Xilin Wu (QMUL: Queen Mary University of London)
#2Emily Goodchild (QMUL: Queen Mary University of London)
Last. Morris J. Brown (QMUL: Queen Mary University of London)H-Index: 97
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#1Xilin Wu (QMUL: Queen Mary University of London)
#2Sumedha Garg (University of Cambridge)H-Index: 11
Last. Folma Buss (University of Cambridge)H-Index: 37
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