Manar G. Salem
Suez Canal University
Sulfonylurea receptorProton NMRSelectivityPolyol pathwayReview articleCarbon-13 NMRMolecular modelEnzymeChemistryIn vitroIn vivoCombinatorial chemistryAldose reductaseSorbinilAcetamideEpalrestatRhodanineIC50Ring (chemistry)RepaglinideAldehyde ReductaseBiochemistryStereochemistryPharmacology
4Publications
2H-index
12Citations
Publications 4
Newest
#1Manar G. Salem (Suez Canal University)H-Index: 2
#2Yasmine M. Abdel Aziz (Suez Canal University)H-Index: 6
Last. Mohamed Said (Suez Canal University)H-Index: 17
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Abstract In the present study, a novel generation of selective aldose reductase ALR2 inhibitors with significant hypoglycemic activities was designed and modulated based on rhodanine scaffold joined to an acetamide linker in between two lipophilic moieties. The synthesis of the novel compounds was accomplished throughout simple chemical pathways. Molecular docking was performed on B-cell membrane protein SUR1, aldehyde reductase ALR1 and aldose reductase ALR2 active sites. Compounds 10B, 11B, 12...
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#2Manar G. SalemH-Index: 2
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#1Manar G. Salem (Suez Canal University)H-Index: 2
#2Yasmine M. Abdel Aziz (Suez Canal University)H-Index: 6
Last. Mohamed Said (Suez Canal University)H-Index: 17
view all 5 authors...
Abstract Novel non-sulfonylureas derivatives bearing an acetamide linker between a spirohydantoin scaffold and a phenyl ring were prepared and their hypoglycemic activity was estimated in vivo . Their abilities to discriminate in vitro between aldehyde reductase (ALR1) and aldose reductase (ALR2) were determined. The molecular docking and the in silico prediction studies were performed to rationalize the obtained biological results and to predict the physicochemical properties and drug-likeness ...
4 CitationsSource
#1Manar G. Salem (Suez Canal University)H-Index: 2
#2Yasmine M. Abdel Aziz (Suez Canal University)H-Index: 6
Last. Mohamed Said (Suez Canal University)H-Index: 17
view all 5 authors...
Abstract Novel derivatives of spiroimidazolidinedione were synthesized and evaluated as hypoglycemic agents through binding to sulfonylurea receptor 1 (SUR1) in pancreatic beta-cells. Their selectivity index was calculated against both aldehyde reductase (ALR1) and aldose reductase (ALR2). Aldehyde reductase is a key enzyme in the polyol pathway that is involved in the etiology of the secondary diabetic complications. All structures were confirmed by microanalysis and by IR, 1H NMR, 13C NMR and ...
6 CitationsSource