Manas Ranjan Praharaj
Indian Veterinary Research Institute
GeneInfectivityGlycoproteinPhenotypeInnate immune systemGene expressionVirologyTranscriptomeCD8ReceptorAcquired immune systemBasic reproduction numberViral phylodynamicsVaccinationHsp90PathogenBreedCD14PopulationPeste-des-Petits-RuminantsGeneticsViral entryHsp70PhylogenomicsEvolutionary biologyBiologyImmune systemPhylogeneticsCell biology
12Publications
2H-index
6Citations
Publications 11
Newest
#1Sajad Ahmad Wani (OSU: Ohio State University)H-Index: 5
Last. Ravi Kumar GandhamH-Index: 1
view all 12 authors...
ABSTRACT Immune response is a highly coordinated cascade involving all the subsets of peripheral blood mononuclear cells (PBMCs). In this study, RNA sequencing (RNA-Seq) analysis of PBMC subsets was done to delineate the systems biology behind immune protection of the vaccine in sheep and goats. The PBMC subsets studied were CD4+, CD8+, CD14+, CD21+, and CD335+ cells from day 0 and day 5 of sheep and goats vaccinated with Sungri/96 peste des petits ruminants virus. Assessment of the immune respo...
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#2Priyanka GargH-Index: 2
Last. Trilochan Mohapatra (ICAR: Indian Council of Agricultural Research)H-Index: 46
view all 14 authors...
Background: SARS-CoV-2 is a viral pathogen causing life-threatening disease in human. Interaction between spike protein of SARS-CoV-2 and ACE2 receptor on the cells is a potential factor in the infectivity of a host. The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor - ACE2, in different hosts was evaluated to understand and predict viral entry. The protein and nucleotide sequences of ACE2 were initially compared across different species to identify key differences amo...
Source
#1Raja Ishaq Nabi Khan (IVRI: Indian Veterinary Research Institute)H-Index: 3
#2Amit Ranjan Sahu (IVRI: Indian Veterinary Research Institute)H-Index: 7
Last. Ashok K. Tiwari (IVRI: Indian Veterinary Research Institute)H-Index: 24
view all 18 authors...
Transcriptome profiling of Vrindavani and Tharparkar cattle revealed that more numbers of genes dysregulated in Vrindavani than in Tharparkar. A contrast in gene expression was observed with 18.5 % of upregulated genes in Vrindavani were downregulated in Tharparkar and 17.5% upregulated genes in Tharparkar were downregulated in Vrindavani. Functional annotation of genes differentially expressed in Tharparkar and Vrindavani revealed that the systems biology in Tharparkar is moving towards counter...
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#1Sameera Farah (U of G: University of Guelph)H-Index: 2
#2Ashwin AtkulwarH-Index: 2
Last. Mumtaz Baig (U of G: University of Guelph)H-Index: 1
view all 6 authors...
Background: This is the first phylodynamic study attempted on SARS-CoV-2 genomes from India to infer the current state of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution using phylogenetic network and growth trends Materials & Methods: Out of 286 retrieved whole genomes from India, 138 haplotypes were used to build a phylogenetic network The birth-death serial model (BDSIR) package of BEAST2 was used to calculate the reproduction number of SARS-CoV-2 Population dynamics we...
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#1Sajad Ahmad Wani (OSU: Ohio State University)H-Index: 5
#1Sajad Ahmad Wani (OSU: Ohio State University)H-Index: 3
Last. Ravi Kumar GandhamH-Index: 10
view all 11 authors...
Abstract Immune response is a highly coordinated cascade involving all the subsets of PBMCs. In this study, RNA-Seq analysis of PBMC subsets - CD4+, CD8+, CD14+, CD21+ and CD335+ cells from day 0 and day 5 of Sungri/96 Peste des Petits Ruminants vaccinated sheep and goats was done to delineate the systems biology behind immune - protection of the vaccine in sheep and goats. Assessment of the immune response processes enriched by the differentially expressed genes in all the subsets suggested a s...
Source
#1Raja Ishaq Nabi Khan (IVRI: Indian Veterinary Research Institute)H-Index: 3
#2Amit Ranjan Sahu (IVRI: Indian Veterinary Research Institute)H-Index: 7
Last. Ashok K. Tiwari (IVRI: Indian Veterinary Research Institute)H-Index: 24
view all 18 authors...
Abstract Heat stress induced by high environmental temperature and humidity affects livestock production and health. With global warming on the uprise, indigenous cattle known for their heat tolerance are gaining importance than the Crossbreds. However, systems biology behind this phenotype in indigenous cattle is less known. This study, revealed novel insights in response to heat stress in Indian cattle (Tharparkar breed – Indigenous breed vs Vrindhavani – Crossbred). The number of DEGs in Cros...
Source
#1Sameera Farah (U of G: University of Guelph)H-Index: 2
#2Ashwin AtkulwarH-Index: 2
Last. Mumtaz Baig (U of G: University of Guelph)H-Index: 1
view all 6 authors...
The ongoing SARS-CoV-2 pandemic is one of the biggest outbreaks after the Spanish flu of 1918. Understanding the epidemiology of viral outbreaks is the first step towards vaccine development programs. This is the first phylodynamics study attempted on of SARS-CoV-2 genomes from India to infer its current evolution in the context of an ongoing pandemic. Out of 286 retrieved SARS-CoV-2 whole genomes from India, 138 haplotypes were generated and analyzed. Median-joining network was built to investi...
Source
#2Priyanka GargH-Index: 2
Last. Trilochan Mohapatra (ICAR: Indian Council of Agricultural Research)H-Index: 46
view all 12 authors...
Background: SARS-CoV-2 is a viral pathogen causing life threatening disease in human. Interaction between spike protein of SARS-CoV-2 and ACE2 receptor on the cells is a potential factor in the infectivity of a host. The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor - ACE2, in different hosts was evaluated to understand and predict viral entry. The protein and nucleotide sequences of ACE2 were initially compared across different species to identify key differences amo...
1 CitationsSource
#2Priyanka GargH-Index: 2
Last. Trilochan Mohapatra (ICAR: Indian Council of Agricultural Research)H-Index: 46
view all 12 authors...
SARS-CoV-2 is a viral pathogen causing life threatening disease in human. Interaction between spike protein of SARS-CoV-2 and ACE2 receptor on the cells is a potential factor in the infectivity of a host. Using in-silico analysis, the protein and nucleotide sequences of ACE2 were initially compared across different species to identify key differences among them. This phylogeny and alignment comparison did not lead to any meaningful conclusion on viral entry facilitation in different hosts. The 6...
1 CitationsSource
#1Raja Ishaq Nabi Khan (IVRI: Indian Veterinary Research Institute)H-Index: 3
#2Amit Ranjan Sahu (IVRI: Indian Veterinary Research Institute)H-Index: 7
Last. Ashok K. Tiwari (IVRI: Indian Veterinary Research Institute)H-Index: 24
view all 18 authors...
Background: Heat stress induced by high environmental temperature and humidity affects livestock production and health. With global warming on the up rise, indigenous cattle known for their heat tolerance are gaining importance than the crossbreds. However, systems biology behind this phenotype in indigenous cattle is less known. In this study using transcriptome analysis, we identified key molecules and pathways that may lead to the heat tolerance phenotype in indigenous cattle (Tharparkar bree...
1 CitationsSource