John V. Wade
United States Department of the Army
AdductPharmacodynamicsPharmacokineticsRadicalSurgeryChemistryElectron paramagnetic resonanceAtropineDiazepamIntramuscular injectionPhysostigmineHydroxyl radicalHuman skinCaviidaeAnticholinergicChlorideNerve agentGuinea pigSpin trappingErythemaHairlessAntidoteComaTrihexyphenidylArterial bloodOximePyridostigmineSomanSulfur mustardEdemaAnticholinergic agentsATROPINE/PRALIDOXIMEToxicityClinical courseAnesthesiaReactive oxygen speciesHydrogen peroxideOxygenMedicinePhotochemistryPharmacology
Publications 5
#1Carmen M. ArroyoH-Index: 12
#2John V. Wade (DA: United States Department of the Army)H-Index: 4
Last. Hiroe Nakazawa (Tokai University)H-Index: 14
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Abstract A possible mechanism by which prostacyclin (PGI 2 ) analogues provide beneficial effects including improved survival in shock experimentally induced by endotoxin, polytrauma or hypovolemia was studied. Since several studies have implicated oxygen free radical-mediated tissue damage, we investigated whether PGI 2 -analogues exert their ‘cytoprotective’ effects by inhibiting overproduction of oxygen free radicals. For this reason, the efficiency of Taprostene to scavenge hydroxyl radicals...
11 CitationsSource
#2Nancy K. JaaxH-Index: 2
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Abstract : The purpose of this study was to estimate the minimal dose of intramuscularly administered diazepam to limit soman-induced convulsions in rhesus monkeys pretreated with pyridostigmine and treated with atropine and 2-PAM. Eleven rhesus monkeys were pretreated with four oral doses of pyridostigmine administered at eight-hour intervals before intramuscular administration of 5 LD50 of soman. All of the animals were-treated with atropine and 2-PAM chloride one minute following exposure to ...
#1J. von BredowH-Index: 1
#2Kevin D. CorcoranH-Index: 6
Last. John V. WadeH-Index: 4
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Abstract Pretreatment of nonhuman primates with physostigmine (Phy) and scopolamine or physostigmine and trihexyphenidyl 25 min before exposure to 2 LD50 soman im resulted in complete survival without convulsions or loss of consciousness. When identically pretreated animals were challenged with 5 LD50s of soman followed by atropine and 2-PAM therapy 1 min later, all animals experienced a loss of consciousness for approximately 10 min followed by functional recovery within an additional 20 min. T...
29 CitationsSource
#1Fred W. Stemler (DA: United States Department of the Army)H-Index: 2
#2Theresa M. Tezak-Reid (DA: United States Department of the Army)H-Index: 2
Last. Isaac J. Hayward (DA: United States Department of the Army)H-Index: 1
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Abstract The pharmacokinetics and cardiovascular pharmacodynamics of two oximes were studied in unanesthetized pigs. Effects of 2-[(hydroxyimino)methyl]-1-methylpyridinium chloride (pralidoxime chloride; 2-PAM Cl; 50 μmon/kg) were compared with those of 1,1-methylene bis[4(hydroxyiminomethyl) pyridinium] dichloride (methoxime; MMB-4; 100 μmol/kg). Cardiopulmonary parameters were monitored and plasma concentrations of oximes were determined from arterial blood samples taken at intervals over a pe...
13 CitationsSource
#1Millard M. MershonH-Index: 6
Last. John V. WadeH-Index: 4
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Abstract Sulfur mustard (HD; 1,1′-thiobis[2-chloroethane]) induces fluid-filled blisters in man but not in conventional laboratory animals. An animal model is needed to emulate both cytotoxic (vesicant) and vascular (irritant) responses of human skin to HD exposures. An acceptable model must permit reproducible comparisons of uniformly graded and dose-related HD control responses with reduced responses that may follow antivesicant treatments. Hairless guinea pigs were evaluated by exposing six o...
86 CitationsSource