Hervé Petite
French Institute of Health and Medical Research
Biomedical engineeringSurgeryPathologyResorptionStromal cellChemistryMaterials scienceMesenchymal stem cellIn vivoBone marrowStem cellTransplantationBone regenerationBone morphogenetic protein 2Tissue engineeringMedicineBone healingBiologyScaffoldCell biology
Publications 175
#1Guotian Luo (École nationale vétérinaire d'Alfort)H-Index: 6
#2Giuliana E Salazar-Noratto (École nationale vétérinaire d'Alfort)H-Index: 1
Last. Hervé Petite (École nationale vétérinaire d'Alfort)H-Index: 32
view all 4 authors...
Abstract null null Allogenic demineralized bone matrix has been developed as a reliable alternative to the autologous bone graft. In the present study, we assessed the osteoformation potential of a partially demineralized bone matrix (PDBM) in a paste form obtained without an added carrier. This formulation included the preparation of cancelous bone from femoral heads after decellularision, delipidation, demineralization in HCl and autoclaving at 121°C. Structural and biochemical characteristics...
#1Pinpin Wang (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Federico Perche (CNRS: Centre national de la recherche scientifique)H-Index: 15
Last. Chantal Pichon (University of Orléans)H-Index: 40
view all 10 authors...
Abstract Messenger RNA (mRNA) activated matrices (RAMs) are interesting to orchestrate tissue and organ regeneration due to the in-situ and sustained production of functional proteins. However, the immunogenicity of in vitro transcribed mRNA and the paucity of proper in vivo mRNA delivery vector need to be overcome to exert the therapeutic potential of RAM. We developed a dual mRNAs system for in vitro osteogenesis by co-delivering NS1 mRNA with BMP2 mRNA to inhibit RNA sensors and enhance BMP-2...
#1Jonathan Ribot (University of Paris)H-Index: 1
#1Jonathan RibotH-Index: 1
Last. Fani Anagnostou (University of Paris)H-Index: 19
view all 8 authors...
Bone marrow-derived multipotent stromal cells (BMMSCs) represent an attractive therapeutic modality for cell therapy in type 2 diabetes mellitus (T2DM)-associated complications. T2DM changes the bone marrow environment; however, its effects on BMMSC properties remain unclear. The present study aimed at investigating select functions and differentiation of BMMSCs harvested from the T2DM microenvironment as potential candidates for regenerative medicine. BMMSCs were obtained from Zucker diabetic f...
#1Jonathan RibotH-Index: 1
#1Jonathan RibotH-Index: 1
Last. Fani AnagnostouH-Index: 19
view all 8 authors...
#1Guotian LuoH-Index: 6
#2Cyprien DenoeudH-Index: 2
Last. Hervé PetiteH-Index: 32
view all 5 authors...
#1Nathanael Larochette (École nationale vétérinaire d'Alfort)H-Index: 34
#1Nathanaël Larochette (École nationale vétérinaire d'Alfort)H-Index: 4
Last. Delphine Logeart-Avramoglou (École nationale vétérinaire d'Alfort)H-Index: 25
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Abstract While human bone morphogenetic protein-2 (BMP-2) is a promising growth factor for bone regeneration, a major challenge in biomedical applications is finding an optimal carrier for its delivery at the site of injury. Because of their natural affinities for growth factors (including BMP-2) as well as their role in instructing cell function, cultured cell-derived extracellular matrices (ECM) are of special interest. We hereby hypothesized that a “bony matrix” containing mineralized, osteog...
2 CitationsSource
#1Ines Sherifi (CNRS: Centre national de la recherche scientifique)H-Index: 2
#1Ines Sherifi (CNRS: Centre national de la recherche scientifique)
Last. Didier Hannouche (Geneva College)H-Index: 27
view all 5 authors...
Tissue-engineered grafts may be useful in Anterior Cruciate Ligament (ACL) repair and provide a novel, alternative treatment to clinical complications of rupture, harvest site morbidity and biocompatibility associated with autografts, allografts and synthetic grafts. We successfully used supercritical carbon dioxide (Sc-CO2) technology for manufacturing a "smart" biomaterial scaffold, which retains the native protein conformation and tensile strength of the natural ACL but is decellularized for ...
#1Rebecca Landon (Paris Diderot University)H-Index: 1
#2Virginie Gueguen (University of Paris)H-Index: 14
Last. Fani Anagnostou (Paris Diderot University)H-Index: 19
view all 6 authors...
Oxidative stress (OS) plays a pivotal role in diabetes mellitus (DM) onset, progression, and chronic complications. Hyperglycemia-induced reactive oxygen species (ROS) have been shown to reduce insulin secretion from pancreatic β-cells, to impair insulin sensitivity and signaling in insulin-responsive tissues, and to alter endothelial cells function in both type 1 and type 2 DM. As a powerful antioxidant without side effects, astaxanthin (ASX), a xanthophyll carotenoid, has been suggested to con...
14 CitationsSource
#1Baptiste Charbonnier (Lyon College)H-Index: 3
#2Mathieu Manassero (École nationale vétérinaire d'Alfort)H-Index: 3
Last. Esther Potier (École nationale vétérinaire d'Alfort)H-Index: 7
view all 12 authors...
Abstract The architectural features of synthetic bone grafts are key parameters for regulating cell functions and tissue formation for the successful repair of bone defects. In this regard, macroporous structures based on triply-periodic minimal surfaces (TPMS) are considered to have untapped potential. In the present study, custom-made implants based on a gyroid structure, with (GPRC) and without (GP) a cortical-like reinforcement, were specifically designed to fit an intended bone defect in ra...
4 CitationsSource