Lucie S. Meyer
Ludwig Maximilian University of Munich
Internal medicineUrologyEndocrinologyGermline mutationHyperaldosteronismFamilial hyperaldosteronismAdenomaHyperplasiaAdrenal cortexAldosteroneSingle CenterAdrenalectomyZona glomerulosaPrimary aldosteronismAldosterone synthaseMutationHistopathologyCell growthMedicineCohortBiology
9Publications
4H-index
62Citations
Publications 9
Newest
#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Laura Handgriff (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Unilateral forms of primary aldosteronism are usually surgically treated to remove the source of aldosterone excess. After adrenalectomy, aldosteronism persists in some patients indicating abnormal aldosterone production from the unresected gland. Our objective was to investigate histopathology, genotype, and postsurgical outcomes in a 3-year prospective cohort of surgically treated patients for primary aldosteronism (from 2016 to 2018). The cohort comprised 60 consecutively operated patients ca...
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#1Lucie S. MeyerH-Index: 4
#2Martin ReinckeH-Index: 9
view all 3 authors...
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#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Siyuan Gong (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT1R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT1R-...
1 CitationsSource
#1Na SunH-Index: 10
#2Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Aldosterone-producing adenomas (APAs) are one of the main causes of primary aldosteronism and the most prevalent surgically correctable form of hypertension. Aldosterone-producing cell clusters (AP...
7 CitationsSource
#1Yuhong YangH-Index: 6
#2Lucie S. MeyerH-Index: 4
Last. Tracy Ann WilliamsH-Index: 38
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#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Martin Reincke (LMU: Ludwig Maximilian University of Munich)H-Index: 82
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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The overwhelming majority of cases of primary aldosteronism (PA) occur sporadically due to a unilateral aldosterone-producing adenoma (APA) or bilateral idiopathic adrenal hyperplasia. Familial forms of PA are rare with four subtypes defined to date (familial hyperaldosteronism types I–IV). The molecular basis of familial hyperaldosteronism type I (FH type I or glucocorticoid-remediable aldosteronism) was established in 1992; two decades later the genetic variant causing FH type III was identifi...
2 CitationsSource
#1Yuhong Yang (LMU: Ludwig Maximilian University of Munich)H-Index: 6
#2Celso E. Gomez-Sanchez (UMMC: University of Mississippi Medical Center)H-Index: 79
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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: Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein-coupled inwardly rectifying potassium channel are a cause of primary aldosteronism. These mutations drive aldosterone excess, but their role in cell growth is undefined. Our objective was to determine the role of KCNJ5 mutations in adrenal cell proliferation and apoptosis. The Ki67 proliferative index was positively correlated with adenoma diameter in aldosterone-producing adenomas with a KCNJ5 mutation (r=0.435, P=0....
10 CitationsSource
#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Xiao WangH-Index: 2
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Unilateral primary aldosteronism (PA) is the most common surgically curable form of hypertension that must be accurately differentiated from bilateral PA for therapeutic management (surgical versus...
26 CitationsSource
#1Elke Tatjana Aristizabal Prada (LMU: Ludwig Maximilian University of Munich)H-Index: 9
#2Isabella Castellano (UNITO: University of Turin)H-Index: 27
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I–IV) and the majority of sporadic unilateral aldosterone-producing adenomas has now been resolved. Familial forms of hyperaldosteronism are, however, rare. The sporadic forms of the disease prevail and these are usually caused by either a unilateral ...
9 CitationsSource