Erica Gentilin
University of Padua
NeuriteAbsolute threshold of hearingBiophysicsmicroRNACellNanoparticleIntrinsic apoptosisAudiogramCoding (social sciences)ChemistryField (physics)ApoptosisAutophagyIn vivoOxidative stressBiocompatibilityCisplatinInner earOtotoxicityBone tissueCochlear implantSpiral ganglionDecamethylcyclopentasiloxaneSiliconeDrug deliveryCochleaHearing lossSensorineural hearing lossCerium oxideOrgan of CortiPC12 cell lineProfound hearing impairmentCell cycleRedox activeProgrammed cell deathAnesthesiaReactive oxygen speciesCancer researchViability assaySignal transductionComputational biologyMedicineCell cultureNecroptosisCell biology
8Publications
2H-index
32Citations
Publications 7
Newest
#1Erica Gentilin (UNIPD: University of Padua)H-Index: 2
#2Paolo Gandellini (University of Milan)H-Index: 25
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#1Edi Simoni (UNIPD: University of Padua)H-Index: 18
#2Erica Gentilin (UNIPD: University of Padua)H-Index: 2
Last. Laura Astolfi (UNIPD: University of Padua)H-Index: 42
view all 11 authors...
A cochlear implant (CI) is an electronic device that enables hearing recovery in patients with severe or total hearing loss. Although CIs are a successful treatment for profound hearing impairment, their effectivity may be improved by reducing damages associated with insertion of electrodes in the cochlea, thus preserving residual hearing ability. Inner ear trauma leads to inflammatory reactions altering cochlear homeostasis, reducing post-operative audiological performances and electroacoustic ...
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#1Edi Simoni (UNIPD: University of Padua)H-Index: 18
#2Filippo Valente (UWA: University of Western Australia)H-Index: 3
Last. Laura Astolfi (UNIPD: University of Padua)H-Index: 42
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Abstract Sensorineural hearing loss due to aging, noise exposure, trauma or drug ototoxicity is irreversible because cochlear hair cells and neurons cannot regenerate. Recently, therapeutic strategies involving nanoparticles have been developed as innovative drug delivery systems. Thermodynamically stable liquid crystalline nanoparticles based on the polar lipid glycerol monooleate (GMO NP, cubosomes), nontoxic and able to encapsulate both hydrophilic and hydrophobic compounds, were produced and...
1 CitationsSource
#1Erica Gentilin (UNIPD: University of Padua)H-Index: 2
#2Edi Simoni (UNIPD: University of Padua)H-Index: 18
Last. Laura Astolfi (UNIPD: University of Padua)H-Index: 42
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Cis-diamminedichloridoplatinum (II) (cisplatin) is a chemotherapeutic drug currently prescribed for the treatment of many types of human cancer, but its use is associated with numerous adverse effects, one of which is ototoxicity. Cisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress, autophagy, necroptosis, and then intrinsic apoptosis...
17 CitationsSource
#1Edi Simoni (UNIPD: University of Padua)H-Index: 18
#2Erica Gentilin (UNIPD: University of Padua)H-Index: 2
Last. Laura Astolfi (UNIPD: University of Padua)H-Index: 42
view all 5 authors...
Abstract Cochlear implants, the only way to recover from severe/profound hearing loss, may cause adverse effects, among which reactions to silicone materials coating implant electrodes, leading to apoptosis and necrosis of spiral ganglion cells. Our aim was to evaluate whether three polydimethylsiloxane (PDMS) compounds (hexadimethylsiloxane, octamethyltrisiloxane, decamethylcyclopentasiloxane) used in silicone rods could exert toxic effects on an in vitro neuronal cell model (PC12). Cell viabil...
6 CitationsSource
#1Edi SimoniH-Index: 18
#2Erica GentilinH-Index: 2
Last. Laura AstolfiH-Index: 42
view all 5 authors...