Christopher L. Wolfgang
Johns Hopkins University School of Medicine
CancerInternal medicineRadiologySurgeryPathologyOncologyResectionRetrospective cohort studyCarcinomaPancreatectomyPancreasPancreaticoduodenectomyPancreatic cancerAdenocarcinomaIn patientCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 641
#1Lisa Suzanne Brubaker (BCM: Baylor College of Medicine)H-Index: 2
#2Fabio Casciani (University of Verona)H-Index: 2
Last. Chad G. Ball (U of C: University of Calgary)H-Index: 47
view all 26 authors...
Abstract null null Background null Intraperitoneal drain placement decreases morbidity and mortality in patients who develop a clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD). It is unknown whether multiple drains mitigate CR-POPF better than a single drain. We hypothesize that multiple drains decrease the complication burden more than a single drain in cases at greater risk for CR-POPF. null null null Methods null The Fistula Risk Score (FRS...
#1Min Wang (HUST: Huazhong University of Science and Technology)H-Index: 32
#2Ding Ding (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 51
Last. Chien-Hui Wu (NTU: National Taiwan University)
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Abstract null null AJCC TNM stage and WHO grade (G) are two widely used staging systems to guide clinical management for pancreatic neuroendocrine neoplasms (panNENs), based on clinical staging and pathological grading information, respectively. We proposed to integrate TNM stage and G grade into one staging system (TNMG) and to evaluate its clinical application as a prognostic indicator for panNENs. Accordingly, 5254 patients diagnosed with panNENs were used to evaluate and to validate the appl...
#1Joseph R. Habib (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
#2Yayun Zhu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
Last. William H. Burns (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 20
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Background or purpose null Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). However, the diagnostic adequacy of EUS-FNA is often limited by low cellularity leading to inconclusive results. We aimed to investigate the feasibility and added utility of targeted next-generation sequencing (NGS) on PDAC EUS-FNAs. null Methods null EUS-FNAs were prospectively performed on 59 patients with suspected PDAC (2014-2017) at a hig...
#1A. Floortje van Oosten (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Ding Ding (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 51
Last. Jin He (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
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INTRODUCTION Robotic pancreaticoduodenectomy is slowly gaining acceptance within pancreatic surgery. Advantages have been demonstrated for robotic surgery in other fields, but robust data for pancreaticoduodenectomy is limited. The aim of this study was to compare the short-term outcomes of robotic pancreaticoduodenectomy (RPD) to open pancreaticoduodenectomy (OPD) and laparoscopic pancreaticoduodenectomy (LPD). METHODS Patients who underwent a pancreaticoduodenectomy between January 2011 and Ju...
1 CitationsSource
#1Giovanni Marchegiani (University of Verona)H-Index: 29
#2Tommaso Pollini (University of Verona)H-Index: 8
Last. Roberto Salvia (University of Verona)H-Index: 52
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Importance The progression of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas to malignant disease is still poorly understood. Observational and surgical series have failed to provide comprehensive information. Objective To identify dynamic variables associated with the development of malignant neoplasms by combining pathological features with data from preoperative repeated observations. Design, Setting, and Participants The Crossover Observational Multicentric Study included a...
1 CitationsSource
#1Alex B. Blair (Johns Hopkins University)H-Index: 17
#2Ling Di Yin (JHUSOM: Johns Hopkins University School of Medicine)
Last. Jin He (Johns Hopkins University)H-Index: 40
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OBJECTIVE: The aim of this study was to characterize the patterns and treatment of disease recurrence in patients achieving a pathological complete response (pCR) following neoadjuvant chemoradiation for advanced pancreatic ductal adenocarcinoma (PDAC). SUMMARY OF BACKGROUND DATA: A pCR is an independent predictor for improved survival in PDAC. However, disease recurrence is still observed in these patients. METHODS: Patients with advanced PDAC who were treated with neoadjuvant therapy and had a...
6 CitationsSource
#1Regina Yun (Cedars-Sinai Medical Center)
#2Ammar A. JavedH-Index: 23
Last. Rachel Kruer (Johns Hopkins University)H-Index: 7
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OBJECTIVE To evaluate the impact of postoperative glycemic control on postoperative morbidity in patients undergoing a pancreaticoduodenectomy. METHODS A retrospective study was performed on patients at The Johns Hopkins Hospital between April 2015 and April 2016. Data were collected on postoperative insulin regimens, blood glucose, rates of hyperglycemia and hypoglycemia, and postoperative complications and were evaluated. RESULTS Out of 244 patients, 114 (46.7%) experienced at least 1 hypergly...
#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
#1Ling LiH-Index: 8
#2Gilad Halpert (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 8
Last. Florin M. Selaru (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
view all 22 authors...
Hepatocellular carcinoma (HCC) is the 6th-most common and the 4th-most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC models in which to test new small molecules. Herein, we implemented novel patient-derived organoid (PDO) and patient-derived xenografts (PDX) strategies for high-throughput drug screening. Omacetaxine, an FDA-approved drug for chronic myelogenous leukemia (CML), was fo...
#1Georgios A. Margonis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2Neda Amini (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 27
Last. Matthew J. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 30
view all 26 authors...
Objective:To examine the prognostic impact of tumor laterality in colon cancer liver metastases (CLM) after stratifying by Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutational status.Background:Although some studies have demonstrated that patients with CLM from a right sided (RS) primary c
11 CitationsSource