Kyle Bromma
University of Victoria
Colloidal goldCancerBiophysicsDNA damageCellNanomedicineNanoparticleNanotechnologyChemistryIn vitroIn vivoTumor microenvironmentChemotherapyHeLaDrug deliveryPancreatic cancerDocetaxelPopulationCancer therapyRadiation doseMetal nanoparticlesNormal tissue toxicityCancer researchRadiation therapyMedicineIntracellularCancer cellDistribution (pharmacology)
16Publications
7H-index
103Citations
Publications 16
Newest
#1Abdulaziz Alhussan (UVic: University of Victoria)H-Index: 1
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 10 authors...
Pancreatic cancer is one of the deadliest types of cancer, with a five-year survival rate of only 10%. Nanotechnology offers a novel perspective to treat such deadly cancers through their incorporation into radiotherapy and chemotherapy. However, the interaction of nanoparticles (NPs) with cancer cells and with other major cell types within the pancreatic tumor microenvironment (TME) is yet to be understood. Therefore, our goal is to shed light on the dynamics of NPs within a TME of pancreatic o...
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#1Kyle BrommaH-Index: 7
#2Abdulaziz AlhussanH-Index: 1
Last. Devika B. ChithraniH-Index: 17
view all 6 authors...
Radiotherapy and chemotherapy are the gold standard for treating patients with cancer in the clinic but, despite modern advances, are limited by normal tissue toxicity. The use of nanomaterials, such as gold nanoparticles (GNPs), to improve radiosensitivity and act as drug delivery systems can mitigate toxicity while increasing deposited tumor dose. To expedite a quicker clinical translation, three-dimensional (3D) tumor spheroid models that can better approximate the tumor environment compared ...
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#1Abdulaziz Alhussan (UVic: University of Victoria)H-Index: 1
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 10 authors...
Pancreatic cancer is one of the deadliest with a 5-year survival of 6 to 9%. Nanotechnology offers paradigm-changing opportunity to treat such cancers. Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on...
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According to the global cancer observatory (GLOBOCAN), there are approximately 18 million new cancer cases per year worldwide. Cancer therapies are largely limited to surgery, radiotherapy, and chemotherapy. In radiotherapy and chemotherapy, the maximum tolerated dose is presently being used to treat cancer patients. The integrated development of innovative nanoparticle (NP) based approaches will be a key to address one of the main issues in both radiotherapy and chemotherapy: normal tissue toxi...
5 CitationsSource
#1Kyle Bromma (UVic: University of Victoria)H-Index: 7
#2Aaron Bannister (UVic: University of Victoria)H-Index: 3
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 5 authors...
Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical role: FBs suppress the tumor growth while CAFs promote it. It is not yet known how NPs interact wit...
2 CitationsSource
#1Kyle Bromma (UVic: University of Victoria)H-Index: 7
#2Leah Cicon (UVic: University of Victoria)H-Index: 3
Last. Devika B. ChithraniH-Index: 17
view all 4 authors...
One of the major issues in cancer radiotherapy (RT) is normal tissue toxicity. Introduction of radiosensitizers like gold nanoparticles (GNPs) into cancer cells to enhance the local RT dose has been tested successfully. However, it is not known how GNPs interact with other stromal cells such as normal fibroblasts (FBs) and cancer associated fibroblasts (CAFs) within the tumour microenvironment. It is known that FBs turn into CAFs to promote tumour growth. Hence, we used FBs and CAFs along with H...
5 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 3
#2Dushanthi Dissanayake (UVic: University of Victoria)H-Index: 1
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 6 authors...
Nanoparticles (NPs) have shown promise in both radiotherapy and chemotherapy. NPs are mainly transported along cellular microtubules (MTs). Docetaxel (DTX) is a commonly used chemotherapeutic drug that can manipulate the cellular MT network to maximize its clinical benefit. However, the effect of DTX on NP behaviour has not yet been fully elucidated. We used gold NPs of diameters 15 and 50 nm at a concentration of 0.2 nM to investigate the size dependence of NP behaviour. Meanwhile, DTX concentr...
1 CitationsSource
#1Jan Schuemann (Harvard University)H-Index: 23
#2Alexander F. Bagley (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Sunil Krishnan (Mayo Clinic)H-Index: 79
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This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are bein...
14 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 3
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. ChithraniH-Index: 17
view all 9 authors...
Objective:One of the major issues in current radiotherapy (RT) is the normal tissue toxicity. A smart combination of agents within the tumor would allow lowering the RT dose required while minimizi...
8 CitationsSource
#1Kristy Rieck (UVic: University of Victoria)H-Index: 2
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 6 authors...
Objective: The incorporation of high atomic number materials such as gold nanoparticles (GNPs) into tumor cells is being tested to enhance the local radiotherapy (RT) dose. It is also known that th...
5 CitationsSource