Stefan P. Berger
University Medical Center Groningen
Complement systemInterquartile rangeInternal medicineUrologyEndocrinologySurgeryRenal functionProspective cohort studyImmunologyHazard ratioKidney diseaseLupus nephritisDialysisKidneyKidney transplantationTransplantationProportional hazards modelMedicineUrinary systemBiologyGastroenterology
236Publications
33H-index
3,378Citations
Publications 229
Newest
#1Daan Kremer (UMCG: University Medical Center Groningen)H-Index: 4
#2Tobias T PietersH-Index: 2
Last. Bas W.M. van BalkomH-Index: 29
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Kidney transplant recipients (KTR) may be at increased risk of adverse COVID-19 outcomes, due to prevalent comorbidities and immunosuppressed status. Given the global differences in COVID-19 policies and treatments, robust assessment of all evidence is necessary to evaluate the clinical course of COVID-19 in KTR. Studies on mortality and acute kidney injury (AKI) in KTR in the World Health Organization COVID-19 database were systematically reviewed. We selected studies published between March 20...
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#1Aukje Brat (EUR: Erasmus University Rotterdam)
Last. Stefan P. BergerH-Index: 33
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BACKGROUND Recently, continuous nonoxygenated hypothermic machine perfusion (HMP) has been implemented as standard preservation method for deceased donor kidneys in the Netherlands. This study was designed to assess the effect of the implementation of HMP on early outcomes after transplantation. METHODS Kidneys donated in the Netherlands from 2016 to 2017 were intended to be preserved by HMP. A historical cohort (2010-2014) preserved by static cold storage (CS) was chosen as control group. Prima...
2 CitationsSource
Background and objectives: High dietary acid load may accelerate kidney function decline. We prospectively investigated whether dietary acid load is associated with graft outcomes in kidney transplant recipients and whether venous bicarbonate (HCO3−) mediates this association. null null Design, setting, participants and measurements: We used data from 642 kidney transplant recipients with a functioning graft ≥1 year after transplantation. Net endogenous acid production (NEAP) was estimated using...
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#6Janesh Pillay (UMCG: University Medical Center Groningen)H-Index: 2
BACKGROUND: The mechanisms driving acute kidney injury (AKI) in critically ill COVID-19 patients are unclear null We collected kidney biopsies from COVID-19 AKI patients within 30 min after death in order to examine the histopathology and perform mRNA expression analysis of genes associated with renal injury null METHODS: This study involved histopathology and mRNA analyses of postmortem kidney biopsies collected from patients with COVID-19 (n = 6) and bacterial sepsis (n = 27) null Normal contr...
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#1S E de Boer (UMCG: University Medical Center Groningen)
#2Jan Stephan Sanders (UMCG: University Medical Center Groningen)H-Index: 22
Last. Stefan P. Berger (UMCG: University Medical Center Groningen)H-Index: 33
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BACKGROUND In 2019, more than 30 % of all newly transplanted kidney transplant recipients in The Netherlands were above 65 years of age. Elderly patients are less prone to rejection, and death censored graft loss is less frequent compared to younger recipients. Elderly recipients do have increased rates of malignancy and infection-related mortality. Poor kidney transplant function in elderly recipients may be related to both pre-existing (i.e. donor-derived) kidney damage and increased susceptib...
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#1Camilo G. Sotomayor (UMCG: University Medical Center Groningen)H-Index: 7
#2Charlotte A Te Velde-Keyzer (UMCG: University Medical Center Groningen)H-Index: 3
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 92
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BACKGROUND Galectin-3 may play a causal role in kidney inflammation and fibrosis, which may also be involved in the development of kidney graft failure. With novel galectin-3 targeted pharmacological therapies increasingly coming available, we aimed to investigate whether galectin-3 is associated with risk of late graft failure in kidney transplant recipients (KTR). METHODS We studied adult KTR who participated in TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study, recr...
1 CitationsSource
#1Camilo G. Sotomayor (UMCG: University Medical Center Groningen)H-Index: 7
#2Dion Groothof (UMCG: University Medical Center Groningen)H-Index: 5
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 92
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The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft function. To test this, we performed a prospective cohort study and included 672 outpatient kidney transplant recipients with a functioning graft of beyond one year. The median plasma cadmium was 58 ng/L. During a median 4.9 year...
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Recent studies have shown that depletion of vitamin C is frequent in outpatient kidney transplant recipients (KTR) and that vitamin C is inversely associated with risk of death. Whether plasma vitamin C is associated with death-censored kidney graft failure remains unknown. We investigated KTR who participated in the TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study. The primary outcome was graft failure (restart of dialysis or re-transplantation). Overall and stratifi...
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#1Maria Pippias (UoB: University of Bristol)H-Index: 9
#2Vianda S. Stel (PHRI: Public Health Research Institute)H-Index: 31
Last. Kitty J Jager (PHRI: Public Health Research Institute)H-Index: 15
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Background We investigated ten-year trends in deceased donor kidney quality expressed as the kidney donor risk index (KDRI) and subsequent effects on survival outcomes in a European transplant population. Methods Time trends in the crude and standardised KDRI between 2005-2015, by recipient age, sex, diabetic status, and country were examined in 24,177 adult kidney transplant recipients in seven European countries. We determined five-year patient and graft survival probabilities and the risk of ...
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#1Manuela Yepes-Calderón (UMCG: University Medical Center Groningen)H-Index: 3
#2Camilo G. Sotomayor (UMCG: University Medical Center Groningen)H-Index: 7
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 92
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Urinary liver-type fatty acid-binding protein (uL-FABP) is a biomarker of kidney hypoxia and ischemia, and thus offers a novel approach to identify early kidney insults associated with increased risk of graft failure in outpatient kidney transplant recipients (KTR). We investigated whether uL-FABP is associated with graft failure and whether it improves risk prediction. We studied a cohort of 638 outpatient KTR with a functional graft ≥1-year. During a median follow-up of 5.3 years, 80 KTR devel...
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