Xinhua Zhou
Jinan University
Caspase 3NeurologyMembrane potentialChemistryApoptosisIn vitroNeuroprotectionMechanism of actionOxidative stressTetramethylpyrazineNitroneEdaravoneIodoacetic acidCortex (botany)BiochemistryProtein kinase BIntracellularPI3K/AKT/mTOR pathwayPharmacology
Publications 2
#1Gaoxiao Zhang (JNU: Jinan University)H-Index: 14
#2Tao Zhang (JNU: Jinan University)H-Index: 4
Last. Zaijun Zhang (JNU: Jinan University)H-Index: 22
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Our previous studies demonstrated that the multifunctional agent TBN, a derivative of tetramethylpyrazine armed with a nitrone moiety, displayed high therapeutic efficacy in experimental ischemic stroke models. However, its molecular mechanisms of action underlying the neuroprotective effect need further exploration. In the present study, we found that TBN had significant activities scavenging free radicals such as ·OH, O 2 ·− and ONOO−, inhibiting Ca2+ overload, maintaining mitochondrial functi...
7 CitationsSource
#1Xinhua Zhou (JNU: Jinan University)H-Index: 2
#2Longjun Zhu (JNU: Jinan University)H-Index: 3
Last. Yuqiang Wang (JNU: Jinan University)H-Index: 25
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Edaravone (EDA) is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect. However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA-) induced neuronal death in vitro. In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs) and its possible underlying mechanisms. We found that EDA attenuated IAA-induced cell injury in CGNs. Moreover, ED...
10 CitationsSource