Yuhang Li
Jilin University
DopaminergicGene expressionReceptorTight junctionChemistryNeuroprotectionInflammationNeurodegenerationNF-?BSepsisLipopolysaccharideMicrogliaAMPKSubstantia nigraIntestinal permeabilityIntestinal epitheliumAntibioticsp38 mitogen-activated protein kinasesGut floraSignal transductionProtein kinase BBiologyNeuroinflammationMicrobiologyCell biologyPharmacology
14Publications
9H-index
238Citations
Publications 17
Newest
#2Hualei Wang (JLU: Jilin University)H-Index: 30
#5Yuchen Yang (JLU: Jilin University)H-Index: 5
Innate immune suppression and high blood fatty acid levels are the pathological basis of multiple metabolic diseases. Neutrophil vacuolation is an indicator of the immune status of patients, which is associated with autophagy-dependent granule degradation. Vacuolated neutrophils are observed in ethanol toxicity and septicemia patients due to the changes in their blood constituents, but how about the neutrophils in nonalcoholic fatty liver disease (NAFLD) patient is unknown. Here, we confirmed th...
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#1Wenjin Guo (JLU: Jilin University)H-Index: 11
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 18
view all 10 authors...
Mastitis can seriously damage the physical and mental health of lactating women. The use of antibiotics and anti-inflammatory drugs may damage the flora balance in lactating women. To alleviate mastitis in lactating women and reduce drug-induced damage to the flora, we found that dehydroandrographolide (Deh) has good anti-inflammatory and bacterial balance functions. In vivo, we found that Deh significantly inhibited the expression of MPO, IL6, IL-1β, TNF-α, COX2 and iNOS and reduced pathologica...
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#1Bingxu Huang (JLU: Jilin University)H-Index: 16
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Dianfeng Liu (JLU: Jilin University)H-Index: 11
view all 12 authors...
alpha-Cyperone, extracted from Cyperus rotundus, has been reported to inhibit microglia-mediated neuroinflammation. Oxidative stress and apoptosis play crucial roles in the course of Parkinson's disease (PD). PD is a common neurodegenerative disease characterized by selective death of dopaminergic neurons. This study was designed to investigate the neuroprotective effects of alpha-cyperone against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis in dopaminergic neuronal SH-SY5Y ce...
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#1Yuhang Li (JLU: Jilin University)H-Index: 9
#2Yalong Zeng (JLU: Jilin University)H-Index: 5
Last. Guiqiu Hu (JLU: Jilin University)H-Index: 9
view all 11 authors...
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#4Qing Zhang (JLU: Jilin University)H-Index: 1
Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study was to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways by the Gi protein-coupled receptor and increase pho...
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#1Bingrun Liu (JLU: Jilin University)H-Index: 5
#2Bingxu Huang (JLU: Jilin University)H-Index: 16
Last. Dianfeng Liu (JLU: Jilin University)H-Index: 11
view all 9 authors...
Microglia, proinflammatory M1 and anti-inflammatory M2 phenotypes immune cells in the brain, has the function of phagocytosis of foreign bodies in the central nervous system. Overactivated microglia causes the production of a large number of neurotoxic factors, which cause neuroinflammatory response and then result in brain disorders. Inflammatory response in the brain plays a crucial part in the pathophysiology of many psychiatric and neurological diseases. It has been demonstrated that inhibit...
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#1Yuhang Li (JLU: Jilin University)H-Index: 9
#2Yalong Zeng (JLU: Jilin University)H-Index: 5
Last. Guiqiu Hu (JLU: Jilin University)H-Index: 9
view all 11 authors...
Abstract Neuroinflammation, characterized by the activation of microglia, is one of the major pathologic processes of Parkinson's disease (PD). Overactivated microglia can release many pro-inflammatory cytokines, which cause an excessive inflammatory response and eventually damage dopaminergic neurons. Therefore, the inhibition of neuroinflammation that results from the overactivation of microglia may be an method for the treatment of PD. Farrerol is a 2,3-dihydro-flavonoid obtained from Rhodode...
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#1Bingxu Huang (JLU: Jilin University)H-Index: 16
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Dianfeng Liu (JLU: Jilin University)H-Index: 11
view all 12 authors...
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (SN). Neuroinflammation induced by over-activation of microglia leads to the death of dopaminergic neurons in the pathogenesis of PD. Therefore, downregulation of microglial activation may aid in the treatment of PD. Polydatin (PLD) has been reported to pass through the blood-brain barrier and protect against motor degeneration in the SN. However, the mol...
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#5Yuhang Li (SCUT: South China University of Technology)H-Index: 9
It has been hypothesized that during spark plasma sintering (SPS) the superimposition of an applied pressure enhances mass transfer; however, a pressure-related atomic diffusion coefficient DT has yet to be determined. In this work, we report on the establishment of a framework and illustrate how it can be used to determine the value of DT. In addition, we elucidate the underlying interrelation between the as-determined DT and the densification mechanisms that are active during powder sintering....
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#1Guangxin Chen (Shanxi University)H-Index: 12
#2Bingxu Huang (JLU: Jilin University)H-Index: 16
Last. Juxiong Liu (JLU: Jilin University)H-Index: 13
view all 12 authors...
The intestinal epithelial barrier is important to mucosal immunity, although how it is maintained after damage is unclear. Here, we show that G protein-coupled receptor 109A (GPR109A) supports barrier integrity and decreases mortality in a mouse cecum ligation and puncture (CLP) sepsis model. Data from 16S RNA sequencing showed that the intestinal microbiota of WT and Gpr109a-/- mice clustered differently and their compositions were disrupted after CLP surgery. GPR109A-deficient mice showed incr...
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