Christopher J Black
University of Leeds
Internal medicineSurgeryRandomized controlled trialIntensive care medicineAdverse effectPlaceboIrritable bowel syndromeCrohn's diseaseMEDLINEDiarrheaUlcerative colitisMoodLinaclotideAbdominal painConstipationAnxietyMedicineRelative riskGastroenterologyMeta-analysis
66Publications
13H-index
550Citations
Publications 65
Newest
#1Pavit Luthra (Royal Free Hospital)H-Index: 1
#2Michael Camilleri (Mayo Clinic)H-Index: 146
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 6 authors...
Source
#1Christopher J Black (University of Leeds)H-Index: 13
#2Yan Yiannakou (County Durham and Darlington NHS Foundation Trust)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 4 authors...
Objectives Few studies have examined the effects of applying the Rome IV criteria for irritable bowel syndrome (IBS) vs the previous standard, the Rome III criteria. We conducted a cross-sectional survey of individuals who self-identify as having IBS to examine this issue. Methods We collected complete demographic, symptom, mood, and psychological health data from 1375 adults who self-identified as having IBS, but were not recruited from a referral population. We applied the Rome III and the Rom...
20 CitationsSource
#1Christopher J Black (University of Leeds)H-Index: 13
#2Yuhong Yuan (McMaster University)H-Index: 35
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 7 authors...
Summary Background Although novel therapies for irritable bowel syndrome (IBS) continue to be developed, many doctors rely on more established, traditional therapies as first-line or second-line treatment options. These therapies include soluble fibre (eg, ispaghula husk), antispasmodic drugs, peppermint oil, and gut–brain neuromodulators (including tricyclic antidepressants, selective serotonin reuptake inhibitors, or α-2-δ calcium channel subunit ligands). However, the relative efficacy of tra...
21 CitationsSource
#1Christopher J Black (St James's University Hospital)H-Index: 13
#2Lesley A. Houghton (University of Leeds)H-Index: 53
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 3 authors...
Source
#1Christopher J Black (University of Leeds)H-Index: 13
#2Nicholas E Burr (University of Leeds)H-Index: 14
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 8 authors...
Objective Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty. Design We searched MEDLINE, Embase, Embase Classic, the Cochrane central register of controlled trials, and Clinicaltrials.gov through January 2019 to identify randomised controlled trials (RCTs) assessing the efficacy ...
31 CitationsSource
#1Leonardo Henry Eusebi (UNIBO: University of Bologna)H-Index: 25
#2Christopher J Black (University of Leeds)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 4 authors...
Abstract Objective To determine the effectiveness of management strategies for uninvestigated dyspepsia. Design Systematic review and network meta-analysis. Data sources Medline, Embase, Embase Classic, the Cochrane Central Register of Controlled Trials, and clinicaltrials.gov from inception to September 2019, with no language restrictions. Conference proceedings between 2001 and 2019. Eligibility criteria for selecting studies Randomised controlled trials that assessed the effectiveness of mana...
13 CitationsSource
#1Pavit Luthra (Royal Free Hospital)H-Index: 1
#2Michael Camilleri (Mayo Clinic)H-Index: 146
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 6 authors...
Summary Background There are several drugs available for the treatment of chronic idiopathic constipation, but their relative efficacy is unclear because there have been no head-to-head randomised controlled trials. We did a network meta-analysis to compare the efficacy of these therapies in patients with chronic idiopathic constipation. Methods We searched Medline, Embase, Embase Classic, and the Cochrane Central Register of Controlled Trials for randomised controlled trials published from ince...
22 CitationsSource
#1Christopher J Black (University of Leeds)H-Index: 13
#2Alexander C. Ford (University of Leeds)H-Index: 86
Last. Lesley A. Houghton (University of Leeds)H-Index: 53
view all 3 authors...
1 CitationsSource
#1Shujing Jane Lim (St James's University Hospital)H-Index: 1
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Christopher J Black (University of Leeds)H-Index: 13
view all 8 authors...
BACKGROUND: 23-seleno-25-homo-tauro-cholic acid (SeHCAT) scanning to rule out bile acid diarrhea (BAD) in patients with chronic diarrhea has a high yield. Our previous study showed that patients with terminal ileal (TI) Crohn's disease, TI resection, or cholecystectomy were highly likely to have an abnormal scan. As a result, we encouraged clinicians to use a therapeutic trial of a bile acid sequestrant in these patients, instead of scanning. This may have reduced diagnostic yield of the test, s...
5 CitationsSource
#1Gianluca Ianiro (UCSC: Catholic University of the Sacred Heart)H-Index: 36
#2Leonardo Henry Eusebi (UNIBO: University of Bologna)H-Index: 25
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 6 authors...
BACKGROUND: Increasing evidence supports the role of the gut microbiota in the aetiology of irritable bowel syndrome (IBS). Faecal microbiota transplantation (FMT) is a highly effective treatment against recurrent Clostridioides difficile infection in randomised controlled trials (RCTs), and may be beneficial in ulcerative colitis. However, its efficacy in IBS is uncertain. AIM: To perform a systematic review and meta-analysis to examine this issue. METHODS: We searched MEDLINE, EMBASE, EMBASE C...
50 CitationsSource