Christopher J Black
University of Leeds
Internal medicineSurgeryRandomized controlled trialIntensive care medicineAdverse effectPlaceboIrritable bowel syndromeCrohn's diseaseMEDLINEDiarrheaUlcerative colitisMoodLinaclotideAbdominal painConstipationAnxietyMedicineRelative riskGastroenterologyMeta-analysis
66Publications
13H-index
550Citations
Publications 67
Newest
#1Christopher J Black (St James's University Hospital)H-Index: 13
#2Yan Yiannakou (County Durham and Darlington NHS Foundation Trust)H-Index: 13
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 6 authors...
INTRODUCTION: Conventionally, patients with irritable bowel syndrome (IBS) are subgrouped based on their predominant bowel habit. Given the relevance of psychological comorbidity to IBS symptoms, our aim was to explore an alternative approach to subgrouping by incorporating factors beyond stool form and frequency. METHODS: We collected demographic, symptom, and psychological health data from 1,375 adult subjects in the community who self-identified as having IBS, identifying 2 cohorts meeting ei...
14 CitationsSource
#1Christopher J Black (University of Leeds)H-Index: 13
#2Alexander C. Ford (University of Leeds)H-Index: 86
1 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Lesley A. Houghton (University of Leeds)H-Index: 53
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 6 authors...
Introduction Irritable bowel syndrome (IBS) is a chronic functional bowel disorder, which follows a relapsing and remitting course. Little is known about how evolving definitions of IBS or treatment for the condition affect symptom stability. We conducted a 12-month longitudinal follow-up study of individuals who self-identified as having IBS to examine these issues. Methods We collected demographic, gastrointestinal symptom, mood, and psychological health data at baseline, and gastrointestinal ...
7 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Mohammad Mahdi Zamani (Tehran University of Medical Sciences)H-Index: 12
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 5 authors...
Background: Inflammatory bowel disease (IBD) is a lifelong condition without a cure. Due to bidirectional communication, via the gut-brain axis, as well as the chronicity of symptoms, impaired quality of life, and reduced social functioning, patients with IBD may experience common mental disorders, including anxiety and depression. However, uncertainties remain about the magnitude of this problem. We conducted a systematic review and meta-analysis examining this issue. Methods: MEDLINE, EMBASE, ...
2 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Maria Ines Pinto-Sanchez (McMaster University)H-Index: 14
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 8 authors...
Background Conventionally, patients with functional dyspepsia are subgrouped based on upper gastrointestinal symptoms, according to the Rome criteria. However, psychological co-morbidity and extraintestinal symptoms are also relevant to functional gastrointestinal disorders. Aim To investigate whether it is possible to subgroup people with functional dyspepsia using factors beyond upper gastrointestinal symptoms. Methods We collected demographic, symptom and psychological health data from adult ...
3 CitationsSource
#1Pradeep MundreH-Index: 2
#2Christopher J Black (St James's University Hospital)H-Index: 13
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 4 authors...
Summary Background Treatment of achalasia has changed substantially over the past 20 years. Therapeutic options offered to patients vary, depending on access to both resources and expertise, and include pneumatic dilation (PD), laparoscopic Heller's myotomy (LHM), or per-oral endoscopic myotomy (POEM). Although there are head-to-head trials of these interventions, many of these are small and underpowered, so relative efficacy is unknown. We did a systematic review and network meta-analysis to tr...
5 CitationsSource
#1Christopher J Black (University of Leeds)H-Index: 13
#2Douglas A. Drossman (UNC: University of North Carolina at Chapel Hill)H-Index: 103
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Gastrointestinal symptoms are highly prevalent, but many people who have them will have no organic explanation for their symptoms. Most of these people will be labelled as having a functional gastrointestinal disorder, such as irritable bowel syndrome, functional dyspepsia, or functional constipation. These conditions affect up to 40% of people at any one point in time, and two-thirds of these people will have chronic, fluctuating symptoms. The pathophysiology of functional gastrointestinal diso...
18 CitationsSource
#1Alexander C. Ford (St James's University Hospital)H-Index: 86
#2Paul Moayyedi (McMaster University)H-Index: 115
Last. Yeong Yeh Lee (Universiti Sains Malaysia)H-Index: 24
view all 9 authors...
BACKGROUND Functional dyspepsia (FD) is a relapsing and remitting condition affecting between 5% and 10% of people. Efficacious therapies are available, but their relative efficacy is unknown. AIM To perform a systematic review with network meta-analysis to resolve this uncertainty. METHODS We searched the medical literature through July 2020 for randomised controlled trials (RCTs) assessing efficacy of drugs for adults with FD, compared with each other, or placebo. Trials reported a dichotomous...
9 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Sanjiv Mahadeva (UM: University of Malaya)H-Index: 32
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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BACKGROUND Prevalence of uninvestigated dyspepsia varies across cross-sectional surveys. This may be due to differences in definitions used or study methodology, rather than global variability. AIM To determine the global prevalence of uninvestigated dyspepsia according to Rome criteria. METHODS MEDLINE and EMBASE were searched to identify population-based studies reporting prevalence of uninvestigated dyspepsia in adults (≥18 years old) according to Rome I, II, III or IV criteria. Prevalence of...
9 CitationsSource
#1Christopher J Black (University of Leeds)H-Index: 13
#2Alexander C. Ford (University of Leeds)H-Index: 86
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder affecting 4% to 10% of people worldwide [1], with a substantial impact on the quality of life. The diagnosis is made in patient...
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