Christopher J Black
University of Leeds
Internal medicineSurgeryRandomized controlled trialIntensive care medicineAdverse effectPlaceboIrritable bowel syndromeCrohn's diseaseMEDLINEDiarrheaUlcerative colitisMoodLinaclotideAbdominal painConstipationAnxietyMedicineRelative riskGastroenterologyMeta-analysis
66Publications
13H-index
550Citations
Publications 67
Newest
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Edoardo Savarino (UNIPD: University of Padua)H-Index: 60
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 0 authors...
ABSTRACT null Objectives null There are several licensed drugs for irritable bowel syndrome (IBS) that have proven efficacy in randomized controlled trials (RCTs) but placebo response rates are high. We conducted a systematic review and meta-analysis of licensed drugs to estimate magnitude of placebo response rate according to Food and Drug Administration (FDA)-recommended endpoints, and to assess how this varies with stringency of the endpoint used to define response. null Methods null We searc...
Source
#1Christopher J Black (University of Leeds)H-Index: 13
#2Heidi M Staudacher (Deakin University)H-Index: 20
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 3 authors...
Objective null A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is recommended for irritable bowel syndrome (IBS), if general lifestyle and dietary advice fails. However, although the impact of a low FODMAP diet on individual IBS symptoms has been examined in some randomised controlled trials (RCTs), there has been no recent systematic assessment, and individual trials have studied numerous alternative or control interventions, meaning the best com...
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#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Jonathan P Segal (Imperial College Healthcare)H-Index: 11
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 6 authors...
BACKGROUND 5-aminosalicylates (5-ASAs) are the mainstay of treatment for ulcerative colitis (UC). The optimum preparation, dose, and route of administration for UC remains unclear. We conducted a network meta-analysis to examine this issue. METHODS We searched MEDLINE, EMBASE, EMBASE Classic, and the Cochrane central register of controlled trials from inception to December 2020. We included randomised controlled trials (RCTs) comparing oral, topical, or combined oral and topical 5-ASAs, with eac...
2 CitationsSource
Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction which can have a considerable impact on quality of life. Following diagnosis, timely and evidence-based management is vital to the care of patients with IBS, aiming to improve outcomes, and enhance patient satisfaction. Good communication is paramount, and clinicians should provide a clear explanation about the disorder, with a focus on exploring the patient’s own beliefs about IBS, and a discussion of any concerns they...
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#1Alfred D. Nelson (Mayo Clinic)H-Index: 10
#2Christopher J Black (St James's University Hospital)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 6 authors...
Source
#1Alfred D. Nelson (Mayo Clinic)H-Index: 10
#2Christopher J Black (St James's University Hospital)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 6 authors...
BACKGROUND Although bloating is a highly prevalent and troublesome symptom in irritable bowel syndrome with constipation (IBS-C), treatment is empirical with no specific guidelines for its management. AIM To conduct a pairwise and network meta-analysis, using a frequentist approach, of Food and Drug Administration-licensed drugs for IBS-C comparing their efficacy for abdominal bloating as a specific endpoint. METHODS We searched the medical literature through December 2020 to identify randomised...
2 CitationsSource
#1Christopher J BlackH-Index: 13
#2Orla Craig (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Alexander C. FordH-Index: 86
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Objectives Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. Design We collected complete symptom data from consecutive adult patients with suspected IBS referred to a single UK clinic. All subjects underwent relatively standardised workup, with assessors blinded to symptom status. The refe...
6 CitationsSource
#1Vivek C. Goodoory (St James's University Hospital)
#1Vivek C. Goodoory (St James's University Hospital)
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
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1 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Christopher J Black (University of Leeds)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 4 authors...
BACKGROUND Despite randomized controlled trials [RCTs] and trial-based meta-analyses, the optimal rescue therapy for patients with acute glucorticosteroid-refractory ulcerative colitis [UC], to avoid colectomy and improve long-term outcomes, remains unclear. We conducted a network meta-analysis examining this issue. METHODS We searched MEDLINE, EMBASE, EMBASE Classic and the Cochrane central register up to June 2020. We included RCTs comparing ciclosporin and infliximab, either with each other o...
3 CitationsSource
#1Vivek C. Goodoory (University of Leeds)
#2Lesley A. Houghton (University of Leeds)H-Index: 53
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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ABSTRACT Objectives Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the effects on the natural history of IBS of moving to the latest iteration, Rome IV, from the previous Rome III criteria. We conducted a 12-month longitudinal follow-up study examining this. Methods We collected complete demographic, symptom, mood, and psychological health data at base...
1 CitationsSource