Christopher J Black
St James's University Hospital
Internal medicineSurgeryRandomized controlled trialIntensive care medicineAdverse effectPlaceboIrritable bowel syndromeCrohn's diseaseMEDLINEDiarrheaUlcerative colitisMoodLinaclotideAbdominal painConstipationRome iiiAnxietyMedicineRelative riskGastroenterologyMeta-analysis
92Publications
12H-index
879Citations
Publications 63
Newest
#1Christopher J BlackH-Index: 12
#2Orla Craig (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Alexander C. FordH-Index: 86
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Objectives Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. Design We collected complete symptom data from consecutive adult patients with suspected IBS referred to a single UK clinic. All subjects underwent relatively standardised workup, with assessors blinded to symptom status. The refe...
2 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Christopher J Black (University of Leeds)H-Index: 12
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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BACKGROUND Despite randomized controlled trials [RCTs] and trial-based meta-analyses, the optimal rescue therapy for patients with acute glucorticosteroid-refractory ulcerative colitis [UC], to avoid colectomy and improve long-term outcomes, remains unclear. We conducted a network meta-analysis examining this issue. METHODS We searched MEDLINE, EMBASE, EMBASE Classic and the Cochrane central register up to June 2020. We included RCTs comparing ciclosporin and infliximab, either with each other o...
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#1Vivek C. Goodoory (University of Leeds)
#2Lesley A. Houghton (University of Leeds)H-Index: 54
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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ABSTRACT Objectives Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the effects on the natural history of IBS of moving to the latest iteration, Rome IV, from the previous Rome III criteria. We conducted a 12-month longitudinal follow-up study examining this. Methods We collected complete demographic, symptom, mood, and psychological health data at base...
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#1Alfred D. NelsonH-Index: 10
#2Christopher J BlackH-Index: 12
Last. Alexander C. FordH-Index: 86
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#1Christopher J Black (University of Leeds)H-Index: 12
#2Alexander C. Ford (University of Leeds)H-Index: 86
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#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Mohammad Mahdi Zamani (Tehran University of Medical Sciences)H-Index: 12
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Summary Background Inflammatory bowel disease (IBD) is a lifelong condition with no cure. Patients with IBD might experience symptoms of common mental disorders such as anxiety and depression because of bidirectional communication via the gut–brain axis and chronicity of symptoms, and because of impaired quality of life and reduced social functioning. However, uncertainties remain about the magnitude of this problem. We aimed to assess prevalence of symptoms of anxiety or depression in adult pat...
3 CitationsSource
#1Dipesh H. Vasant (University of Manchester)H-Index: 10
#2Peter Paine (University of Salford)H-Index: 15
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
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Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology (BSG) guideline in 2007, substantial advances have been made in understanding its complex pathophysiology, resulting in its re-classification as a disorder of gut-brain interaction, rather than a functional gastrointestinal disorder. Moreover, there has been a considerable amount of new ev...
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#1Christopher J Black (St James's University Hospital)H-Index: 12
#2Alexander C. Ford (St James's University Hospital)H-Index: 86
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#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Yan Yiannakou (County Durham and Darlington NHS Foundation Trust)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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ABSTRACT Objectives Disorders of gut-brain interaction, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD) frequently overlap, but the impact of this on the natural history is unknown. We examined this issue in a longitudinal follow-up study conducted in a large cohort of individuals. Methods We collected complete demographic, symptom, mood, and psychological health data from 1374 adults who self-identified as having IBS. We applied the Rome IV criteria to examine what proporti...
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#1Vivek C. Goodoory (County Durham and Darlington NHS Foundation Trust)
#2Antonina Mikocka-Walus (University of Leeds)
Last. Alexander C. FordH-Index: 86
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INTRODUCTION Psychological comorbidities are associated with irritable bowel syndrome (IBS), but little is known about their cumulative effect on its prognosis. We examined this issue in a longitudinal 12-month follow-up study. METHODS We collected complete demographic, symptom, and psychological comorbidity data (anxiety, depression, somatic symptom disorder, perceived stress, and gastrointestinal symptom-specific anxiety) at baseline from 807 adults who met Rome IV criteria for IBS. At 12 mont...
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