Denise E. Jackson
RMIT University
Collagen receptorInternal medicineMolecular biologyAntibodyCell adhesion moleculeReceptorIntegrin alpha MChemistryIntegrinImmunologyIn vivoTetraspaninGPVIThrombusPlatelet activationBiochemistrySignal transductionMedicineBiologyPlateletCell biologyPharmacology
57Publications
24H-index
1,738Citations
Publications 60
Newest
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#1Fahd A. Kuriri (Shaqra University)H-Index: 2
#2Genia F. Burchall (RMIT: RMIT University)H-Index: 4
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
view all 7 authors...
The immunoglobulin (Ig)–immunoreceptor tyrosine–based inhibitory motif (ITIM) bearing receptors, PECAM-1 and CEACAM1 have been shown net negative regulators of platelet-collagen interactions and hemi-ITAM signalling pathways. null In this study, a double knockout (DKO) mouse null was developed with deleted PECAM-1 and CEACAM1 to study their combined contribution in platelet activation by glycoprotein VI, C-type lectin-like receptor 2 (CLEC-2), protease activated receptor PAR-4, ADP purinergic re...
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#2Mohammad AlgahtaniH-Index: 1
#3Hassan A Hamali (JazanU: Jazan University)H-Index: 2
Last. Gasim Dobie (JazanU: Jazan University)H-Index: 2
view all 12 authors...
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) accounting for 3%–10% of primary AML in childhood. Clinical manifestations of AML patients can include low grade of fever, diarrhea, easy bruising, failure to growth, and life-threatening clinical manifestations. Laboratory tests are very crucial to make a definitive diagnosis and treatment. We report here an uncommon case of AMKL in a 12-month-old boy who presented with general paleness and fatigue. Based on blo...
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#1Alshehri Aa (RMIT: RMIT University)H-Index: 1
#2Denise E. Jackson (RMIT: RMIT University)H-Index: 24
Abstract Hemolytic disease of fetus and newborn (HDFN) imposes great healthcare burden being associated with maternal alloimmunization against parental-inherited fetal red blood cell antigens causing fetal anemia or death. Non-invasive pre-natal analysis (NIPT) provides safe foetal RHD genotyping for early identification of risk pregnancies and proper management guidance. We aimed to conduct systematic review and meta-analysis on NIPT's beneficial application, in conjunction with quantitative ma...
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#1Zachary Powell (RMIT: RMIT University)
#2Nan Jiang (RMIT: RMIT University)
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
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Despite stringent testing protocols, there always remains a chance of a delayed haemolytic transfusion reaction (DHTR) occurring as a result of an undetected or unknown antibody. In this systemic review and meta-analysis, we aimed to investigate improvements to patient outcomes that could be achieved through the implementation of a national antibody registry. A series of searches through PubMed and SCOPUS identified a collection of articles with relevant information, restricted to full text, Eng...
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#1Abdullah Yahya Hamadi (University of Tabuk)H-Index: 2
#2Ali Mahzari (Al Baha University)H-Index: 2
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
view all 9 authors...
COVID-19 (Virus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) is a pandemic disease characterized with respiratory infection caused by coronavirus. It has worldwide after an outbreak began in Wuhan, China, in December 2019. SARS-CoV-2 has infected more than 15 million people globally. The disease severity and mortality increased in patients with heart-related comorbidities. Cardiovascular disease patients are more susceptible and infected with SARS-CoV-2. Early screening...
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#1Fehaid Alanazi (RMIT: RMIT University)H-Index: 2
#2Faith A.A. Kwa (RMIT: RMIT University)H-Index: 7
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
view all 4 authors...
Multiple myeloma (MM), a plasma cell malignancy, is characterized by lesions in multiple bones involving transformed, matured post-follicular B cells. The course of the disease involves an initial development of monoclonal gammopathy of undetermined significance (MGUS), followed by smoldering MM, before the full MM disease emerges. Despite novel therapies, MM remains incurable, managed by combination therapies, including proteasome inhibitors (PIs), immunomodulators (IMiDs) and anti-human CD38 (...
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#1Gasim Dobie (RMIT: RMIT University)H-Index: 2
#2Fahd A. Kuriri (RMIT: RMIT University)H-Index: 2
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
view all 10 authors...
The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has proven to be efficacious in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) and related diseases. However, a major adverse side effect of ibrutinib is bleeding, including major hemorrhages. The bleeding associated with ibrutinib use is thought to be due to a combination of on-target irreversible Btk inhibition, as well as off-target inhibition of other kinases, including EGFR, ITK, JAK3, and Tec kinase. In this study, we inv...
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#1Abdullah Yahya Hamadi (RMIT: RMIT University)H-Index: 2
#2Andrew Grigg (Austin Hospital)H-Index: 67
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
view all 7 authors...
Both nilotinib, a second-generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukaemia (CML), and ponatinib, a third-generation TKI used in CML and Philadelphia positive acute lymphocytic leukaemia, have been associated with an increase in arterial occlusive events, in contrast to other TKIs such as imatinib and dasatinib. We have previously demonstrated evidence of a pro-thrombotic state associated with nilotinib, using microvascular and arterial thrombosis C57BL...
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