Yun-Xuan Tan
Chinese Academy of Sciences
IsomerizationStereocenterAtom economyEnantioselective synthesisMedicinal chemistryCatalysisChemistryConjugateCombinatorial chemistryFunctional groupAlkyneKinetic resolutionElectrophileRhodiumYield (chemistry)Cascade reactionRegioselectivityAldol reactionStereochemistryIntramolecular force
17Publications
6H-index
100Citations
Publications 18
Newest
#1Yun-Xuan Tan (SHU: Shanghai University)H-Index: 6
#2Pei-Ying Peng (SHU: Shanghai University)H-Index: 1
Last. Ping Tian (SHU: Shanghai University)H-Index: 17
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A diastereo- and enantioselective rhodium(III)-catalyzed reductive cyclization of cyclohexadienone-tethered terminal alkenes and (E)-1,2-disubstituted alkenes (1,6-dienes) is reported, providing cis-bicyclic products bearing three contiguous stereocenters with good yields and high diastereo- and enantioselectivities. The kinetic resolution of the racemic precursor is also achieved with good efficiency. Moreover, a subgram-scale experiment, several transformations of the cyclization product, and ...
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#1Hao Xu (SHU: Shanghai University)H-Index: 1
#2Yun-Xuan Tan (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Guo-Qiang Lin (SHU: Shanghai University)H-Index: 24
view all 11 authors...
1 CitationsSource
#1Kairui Feng (SHU: Shanghai University)H-Index: 4
#2Yun-Xuan Tan (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Guo-Qiang Lin (CAS: Chinese Academy of Sciences)H-Index: 24
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The Cu-catalyzed asymmetric carboboration of cyclohexadienone-tethered allenes has been achieved through regioselective β-borylation of the allenes and subsequent conjugate addition to cyclohexadienones, affording cis-bicyclic frameworks with acceptable yields and high to excellent enantioselectivities. Further conjugate borylation of the carboboration products proved to be a favorable kinetic resolution process, which improved the overall enantioselectivity. Finally, one-pot preparation of high...
3 CitationsSource
#1Yun-Xuan Tan (CAS: Chinese Academy of Sciences)H-Index: 6
#2Xing-Yu Liu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Ping Tian (CAS: Chinese Academy of Sciences)H-Index: 17
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Abstract The transition-metal-catalyzed carboboration of heterobicyclic alkenes has been already established, however, the asymmetric version has never been uncovered. Herein, we describe a Rh(III)-catalyzed asymmetric carboboration of heterobicyclic alkenes, including 7-oxa- and 7-azabenzonorbornadienes, via borylative dimerization. During the transformation, another heterobicyclic alkene acts as electrophilic carbon reagent. The carboboration product bearing seven chiral centers could be effic...
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#1Qing-Hua Li (SHU: Shanghai University)H-Index: 7
#2Dingding Gao (SHU: Shanghai University)H-Index: 3
Last. Ping Tian (CAS: Chinese Academy of Sciences)H-Index: 17
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Summary Bridged and fused polycyclic structures are found in a huge number of natural products. Significant progress has been made on their syntheses; however, facile and practical strategies to afford polycycles with tunable substituents and functional groups remain rare. Here, we report a practical rhodium(III)-catalyzed asymmetric borylative cyclization of cyclohexadienone-containing 1,6-enynes, affording highly enantioenriched cis-bicyclic frameworks with great functional group compatibility...
1 CitationsSource
#1Kairui Feng (SHU: Shanghai University)H-Index: 4
#2Feng Wang (SHU: Shanghai University)H-Index: 2
Last. Ping Tian (CAS: Chinese Academy of Sciences)H-Index: 17
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Abstract Persistently activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the development of multiple cancers, and therefore is a potential therapeutic target for cancer prevention. Herein, we report the rational design, synthesis, and biological evaluation of novel potent STAT3 inhibitors based on BBI608. Among them, compound A11 exhibited the most potent in vitro tumor cell growth inhibitory activities toward MDA-MB-231, MDA-MB-468 and HepG2 cells wi...
4 CitationsSource
#1Cheng-Yu He (CWNU: China West Normal University)H-Index: 3
#2Yun-Xuan Tan (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Guo-Qiang Lin (CAS: Chinese Academy of Sciences)H-Index: 24
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Among about 150 identified allenic natural products, the exocyclic allenes constitute a major subclass. Substantial efforts are devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. Herein, we show an efficient strategy for the asymmetric synthesis of chiral exocyclic allenes with the simultaneous control of axial and central chirality through copper(I)-catalyzed asymmetric intramolecular reductive coupling of 1,3-enyne...
12 CitationsSource
#1Yun-Xuan TanH-Index: 6
#2Xing-Yu Liu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Guo-Qiang Lin (CAS: Chinese Academy of Sciences)H-Index: 24
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Different from the established trans-endo-selective cyclization of alkyne-tethered electrophiles that involved an E/Z isomerization process, herein, we presented a novel strategy to allow trans-exo...
3 CitationsSource
#1Dingding Gao (SHU: Shanghai University)H-Index: 3
#2Xing-Yu Liu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Ping Tian (CAS: Chinese Academy of Sciences)H-Index: 17
view all 9 authors...
An efficient one-pot synthesis of multisubstituted 9,10-dihydrophenanthrenes from easily available 2-arylazaarenes and cyclohexadienone-tethered terminal alkynes (1,6-enynes) has been successfully ...
4 CitationsSource
#1Xing-Yu Liu (CAS: Chinese Academy of Sciences)H-Index: 4
#2Yun-Xuan Tan (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Guo-Qiang Lin (CAS: Chinese Academy of Sciences)H-Index: 24
view all 7 authors...
A nickel(II)-catalyzed addition of aryl-, alkenyl-, and alkylboronic acids to alkenylazaarenes was presented. This reaction exhibited high efficiency (up to 93% yield), a broad substrate scope (sev...
1 CitationsSource