Lingyun Li
Nanjing Medical University
Downregulation and upregulationCellNotch signaling pathwayBone remodelingGene knockdownApoptosisIn vivoBone metastasisOsteoblastJAG1MetastasisAngiogenesisCartilageChondrocyteTube formationCancer researchBreast cancerMedicineBiologyCell biology
8Publications
3H-index
31Citations
Publications 8
Newest
#1Yucui Jin (Nanjing Medical University)H-Index: 6
Last. Changyan MaH-Index: 9
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#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Dong Li (Nanjing University of Chinese Medicine)H-Index: 1
Last. Wei Zhang (Nanjing Medical University)H-Index: 25
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Osteoporosis is a complex multifactorial disorder characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures or broken bones. Balanced bone remodeling is tightly regulated by the differentiation, activity and apoptosis of bone‑forming osteoblasts and bone‑resorbing osteoclasts. MicroRNAs (miRs) are dysregulated in osteoporosis, but whether they control osteogenic differentiation and skeletal biology, or could serve as therapeutic targets remains to be eluci...
2 CitationsSource
#1Jiashu Yang (Nanjing Medical University)H-Index: 1
#2Yuting Tang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Following a specific number of mitotic divisions, primary chondrocytes undergo proliferative senescence, thwarting efforts to expand sufficient populations in vitro suitable to meet the needs of scientific research or medical therapies. Therefore, the human telomerase reverse transcriptase (TERT) was used to immortalize human chondrocyte and establish a cell line that escape from cellular senescence. The human chondrocytes were successfully immortalized by ectopic stable expression of TERT. The ...
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#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Lingyun Li (Nanjing Medical University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Abstract Osteoporosis is a bone disease characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures. Icariin (ICA), an active flavonoid glucoside isolated from Herba epimedii (HEF), is a potent stimulator of osteogenic differentiation and has potential applications for preventing bone loss in postmenopausal women. However, the molecular mechanism underlying the osteogenic effect of ICA has not yet been fully elucidated. In this study, we report that ICA trea...
4 CitationsSource
#1Qianyi Bao (Nanjing Medical University)H-Index: 4
#2Dawei Yang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Abstract Osteoarthritis (OA) is a chronic joint disease and hard to cure at present. Alpha B-crystallin (CRYAB) has been identified as a downregulated gene in OA cartilage. However, the precise roles and underlying molecular mechanisms of CRYAB in OA progression have not been elucidated. In the present study, we found that the expression of CRYAB in cartilages from patients with OA was significantly lower than that in the cartilages from patients with no prior medical history of OA. We establish...
1 CitationsSource
#1Shuang Qu (Nanjing Medical University)H-Index: 4
#2Jiahui Wu (Nanjing Medical University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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: As a key transcription factor required for bone formation, osterix (OSX) has been reported to be overexpressed in various cancers, however, its roles in breast cancer progression remain poorly understood. In this study, we demonstrated that OSX was highly expressed in metastatic breast cancer cells. Moreover, it could upregulate the expression of S100 calcium binding protein A4 (S100A4) and potentiate breast cancer cell migration and tumor angiogenesis in vitro and in vivo. Importantly, inhibi...
5 CitationsSource
#1Bing Yao (Nanjing Medical University)H-Index: 5
#2Jue Wang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
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Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragmentary. Osterix (Osx) is a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation. Here, we identified the functional roles of Osx in facilitating breast cancer invasion and bone metastasis. Osx up...
17 CitationsSource
#1Jiahui Wu (Nanjing Medical University)H-Index: 3
#2Xiang Chen (Jiangsu University)H-Index: 3
Last. Changyan MaH-Index: 9
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Background/Aims: Osterix (Osx), a key regulator of osteoblast differentiation and bone formation, has been recently reported to be associated with the progression
3 CitationsSource
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