Yeo Wool Kang
Inha University
CancerDNA repairDNA damageNotch signaling pathwayTropomyosin receptor kinase APlatelet-derived growth factor receptorKinaseChemistryApoptosisImmunologyIn vivoMechanism of actionProximity ligation assayRadiosensitizerEpithelial cell adhesion moleculeChemotherapyMelatoninSorafenibMetastasisDrug deliveryPancreatic cancerGemcitabineAngiogenesisKRASTargeted therapyMelatonin receptorDoxorubicinStat3 Signaling PathwayCell cycleProgrammed cell deathTyrosine kinaseCancer researchRadiation therapyViability assayMAPK/ERK pathwayRadioresistanceMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyAnnexinCancer cell
6Publications
5H-index
70Citations
Publications 6
Newest
#1Ji-Eun Lee (Inha University)H-Index: 18
#2Yeo Wool Kang (Inha University)H-Index: 5
Last. Soon-Sun Hong (Inha University)H-Index: 37
view all 18 authors...
KRAS mutation is associated with the progression and growth of pancreatic cancer and contributes to chemo-resistance, which poses a significant clinical challenge in pancreatic cancer. Here, we developed a RT22-ep59 antibody (Ab) that directly targets the intracellularly activated GTP-bound form of oncogenic KRAS mutants after it is internalized into cytosol by endocytosis through tumor-associated receptor of extracellular epithelial cell adhesion molecule (EpCAM) and investigated its synergisti...
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#1Yeo Wool Kang (Inha University)H-Index: 5
#2Ji Eun Lee (Inha University)H-Index: 4
Last. Soon-Sun Hong (Inha University)H-Index: 37
view all 15 authors...
Abstract Pancreatic cancer exhibits an oncogenic KRAS mutation rate of ∼90%. Despite research and drug development efforts focused on KRAS, no targeted therapy has been clinically approved for the treatment of pancreatic cancer with KRAS mutation. Also, the efficacy of gemcitabine is poor due to rapidly acquired resistance. We developed RT11-i antibody, which directly targets the intracellularly activated GTP-bound form of oncogenic RAS mutants. Here, we investigated the combined effects of RT11...
19 CitationsSource
#1Zhenghuan Fang (Inha University)H-Index: 8
#2Boreum Han (Inha University)H-Index: 5
Last. Soon-Sun Hong (Inha University)H-Index: 37
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Abstract Tropomyosin-related kinase A (TrkA) plays important roles in tumor cell growth and survival signaling and contributes to chemo-resistance in pancreatic cancer. Therefore, we developed KK5101, a novel TrkA target inhibitor and assessed its anti-cancer effects and investigated underlying mechanism of action in pancreatic cancer. KK5101 was characterized to inhibit TrkA selectively and potently by protein binding assay. It effectively inhibited the growth and proliferation of pancreatic ca...
5 CitationsSource
#1Zhenghuan FangH-Index: 8
#2Kyung Hee JungH-Index: 28
Last. Soon-Sun HongH-Index: 37
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BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with poor prognosis. Conventional chemotherapies including gemcitabine have failed owing to weak response and side effects. Hence novel treatment regimens are urgently needed to improve the therapeutic efficacy. In this study, we aimed to assess the anticancer activity of melatonin and sorafenib as a novel therapy against PDAC. METHODS: We used various apoptosis assay and PDAC xenograft model to a...
8 CitationsSource
#1Jung Hee Park (Inha University)H-Index: 7
#2Kyung Hee Jung (Inha University)H-Index: 28
Last. Soon-Sun HongH-Index: 37
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// Jung Hee Park 1, * , Kyung Hee Jung 1, * , Soo Jung Kim 1 , Zhenghuan Fang 1 , Hong Hua Yan 1 , Mi Kwon Son 1 , Juyoung Kim 1 , Yeo Wool Kang 1 , Ji Eun Lee 1 , Boreum Han 1 , Joo Han Lim 2 and Soon-Sun Hong 1 1 Department of Drug Development, College of Medicine, Inha University, Sinheung-dong, Jung-gu, Incheon 400-712, Republic of Korea 2 Department of Internal Medicine, College of Medicine, Inha University, Sinheung-dong, Jung-gu, Incheon 400-712, Republic of Korea * These authors have con...
17 CitationsSource
#1Soo Jung Kim (Inha University)H-Index: 12
#2Kyung Hee Jung (Inha University)H-Index: 28
Last. Soon-Sun Hong (Inha University)H-Index: 37
view all 10 authors...
Abstract Tumor vessels are leaky and immature, which causes poor oxygen and nutrient supply to tumor vessels and results in cancer cell metastasis to distant organs. This instability of tumor blood vessels also makes it difficult for anticancer drugs to penetrate and reach tumors. Numerous tumor vessel normalization approaches have been investigated for improving drug delivery into tumors. In this study, we investigated whether phosphoinositide 3-kinase (PI3K) inhibitors are able to improve vasc...
21 CitationsSource