Daniel R. Schmidt
Massachusetts Institute of Technology
Malate-aspartate shuttleErgFusion geneCancerInternal medicineTranslational researchSomatic cellCell migrationOncologyChemistryIn vivoMetabolomicsTumor microenvironmentProstateClinical OncologyMetaboliteCarcinomaPTENTMPRSS2MetastasisLower riskProstate cancerBody mass indexGynecologyOmics technologiesNormal tissueOrganoidConfidence intervalMorphology (biology)Cancer researchCarcinogenesisBioinformaticsMedicineNAD+ kinaseIntracellularTranscription factorBiologyCell biologyCancer cellEctopic expressionCytosol
Publications 6
#1Daniel R. Schmidt (MIT: Massachusetts Institute of Technology)H-Index: 2
#1Daniel Schmidt (MIT: Massachusetts Institute of Technology)H-Index: 48
Last. Jason W. Locasale (Duke University)H-Index: 68
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Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is ...
2 CitationsSource
#1Xiaoshuang Feng (Harvard University)H-Index: 1
#2Cindy Ke Zhou (Harvard University)H-Index: 3
Last. Lorelei A. Mucci (Harvard University)H-Index: 86
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Background: The TMPRSS2: ERG gene fusion and PTEN loss are two of the most common somatic molecular alterations in prostate cancer. Here we investigated the association of pre-diagnostic circulating metabolomics and prostate cancer defined by ERG or PTEN status to improve understanding of these etiologically distinct molecular prostate cancer subtypes. Methods: The study was performed among 277 prostate cancer cases with ERG status, 211 with PTEN status, and 294 controls nested in the Health Pro...
#1H. Furkan Alkan (Graz University of Technology)H-Index: 4
#2Paul W. Vesely (Harvard University)H-Index: 4
Last. Juliane G. Bogner-Strauss (Graz University of Technology)H-Index: 17
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Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth. Here, we report the impact of AGC1-knockdown on metastasis. Low AGC1 expr...
1 CitationsSource
#1Veena Venkatachalam (MIT: Massachusetts Institute of Technology)H-Index: 9
#1V. Venkatachalam (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. M. Vander Heiden (MIT: Massachusetts Institute of Technology)H-Index: 1
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2 CitationsSource
#1Hubert Pakula (Harvard University)H-Index: 5
#2Douglas E. Linn (Harvard University)H-Index: 4
Last. Zhe Li (Harvard University)H-Index: 28
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: TMPRSS2/ERG is the most common type of gene fusions found in human prostate cancer. There are two important features of TMPRSS2/ERG fusions. One is that these gene fusions lead to ectopic expression of ERG, an ETS family transcription factor, in prostate epithelial cells from the 5' control region of an androgen/estrogen dual-responsive gene, TMPRSS2; the other is that ~60% of these fusions are generated via intrachromosomal deletion of the interstitial region between TMPRSS2 and ERG. To recap...
1 CitationsSource
#1Rebecca E. Graff (Harvard University)H-Index: 15
#2Thomas U. Ahearn (Harvard University)H-Index: 14
Last. Lorelei A. Mucci (Harvard University)H-Index: 86
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Background: The largest molecular subtype of primary prostate cancer is defined by the TMPRSS2:ERG gene fusion. Few studies, however, have investigated etiologic differences by TMPRSS2:ERG status. Because the fusion is hormone-regulated and a man9s hormonal milieu varies by height and obesity status, we hypothesized that both may be differentially associated with risk of TMPRSS2:ERG-defined disease. Methods: Our study included 49,372 men from the prospective Health Professionals Follow-up Study....
9 CitationsSource