Amy S. Paller
Northwestern University
Internal medicinePathologyDermatologyRandomized controlled trialChemistryAdverse effectImmunologyPlaceboIchthyosisAtopic dermatitisDiseaseCrisaboroleDupilumabPsoriasisEczema Area and Severity IndexEpidermolysis bullosaDisease severityClinical trialGeneticsMedicineBiologyCell biology
Publications 329
#1Christopher H. Arehart (Anschutz Medical Campus)
#2Michelle Daya (Anschutz Medical Campus)H-Index: 17
Last. Richard L. Gallo (UCSD: University of California, San Diego)H-Index: 137
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Abstract null null Background null While numerous genetic loci associated atopic dermatitis (AD) have been discovered, to date, work leveraging the combined burden of AD risk variants across the genome to predict disease risk has been limited. null null null Objective null This study aims to determine if polygenic risk scores (PRSs) relying on genetic determinants for AD provide useful predictions for disease occurrence and severity. We also explicitly test the value of including genome wide ass...
#1Emma Guttman-Yassky (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 73
Last. Alan D. Irvine (Trinity College, Dublin)H-Index: 73
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Summary Background Upadacitinib is an oral Janus kinase (JAK) inhibitor with greater inhibitory potency for JAK1 than JAK2, JAK3, and tyrosine kinase 2. We aimed to assess the efficacy and safety of upadacitinib compared with placebo for the treatment of moderate-to-severe atopic dermatitis. Methods Measure Up 1 and Measure Up 2 were replicate multicentre, randomised, double-blind, placebo-controlled, phase 3 trials; Measure Up 1 was done at 151 clinical centres in 24 countries across Europe, No...
2 CitationsSource
#1Andi Wang (NU: Northwestern University)H-Index: 1
#2Gabrielle A. Morgan (Children's Memorial Hospital)H-Index: 4
Last. Lauren M. Pachman (NU: Northwestern University)H-Index: 66
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Abstract Background Persistent skin manifestations, especially calcinoses, contribute to morbidity in children with juvenile dermatomyositis (JDM). Objective To compare the course of skin and muscle involvement and document frequency of calcinosis in JDM. Methods Prospective cohort study of 184 untreated children with JDM (July 1971-May 2019) at a single children’s hospital Results Disease activity scores (DAS) were persistently higher for skin vs muscle at all time points; clinical inactivity (...
2 CitationsSource
#1Nicole C. Nowak (NU: Northwestern University)
#2Daniela M. Menichella (NU: Northwestern University)H-Index: 13
Last. Amy S. Paller (NU: Northwestern University)H-Index: 36
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Type 2 diabetes (T2D) is associated with several potential comorbidities, among them impaired wound healing, chronic ulcerations, and the requirement for lower extremity amputation. Disease-associated abnormal cellular responses, infection, immunological and microvascular dysfunction, and peripheral neuropathy are implicated in the pathogenesis of the wound healing impairment and the diabetic foot ulcer. The skin houses a dense network of sensory nerve afferents and nerve-derived modulators, whi...
#1Amy S. PallerH-Index: 36
#2Andreas WollenbergH-Index: 65
Last. Faisal A. KhokharH-Index: 3
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#1Dennis RyuH-Index: 3
#2Dong-Hyun KimH-Index: 118
Last. Shuai Xu (NU: Northwestern University)H-Index: 22
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Vital signs monitoring is a fundamental component of ensuring the health and safety of women and newborns during pregnancy, labor, and childbirth. This monitoring is often the first step in early detection of pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal and neonatal morbidity and mortality. Contemporary pregnancy monitoring systems require numerous devices wired to large base units; at least five separate devices with distinct user inte...
Purpose of review To describe new and emerging therapies for pediatric atopic dermatitis (AD). Recent findings Recent investigations have highlighted the importance of type 2 immunity and interrelationships among the skin immune system, epidermal barrier, and microbiome in the pathogenesis of AD, including in infants and children. These discoveries have translated into more targeted therapy. Crisaborole ointment, a topical phosphodiesterase 4 (PDE4) inhibitor, and dupilumab, a subcutaneously inj...
#1Anna B. Fishbein (NU: Northwestern University)H-Index: 17
#2Brian T. Cheng (NU: Northwestern University)H-Index: 5
Last. James W. Griffith (NU: Northwestern University)H-Index: 35
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Abstract Rationale Atopic dermatitis(AD) causes sleep disturbance, yet the epidemiology is not known. Objective Estimate the US prevalence of sleep disturbance and its impact on psychological and neurocognitive function. Methods Cross-sectional survey of 180 parent-child dyads with AD, using stratified sampling based on disease severity(POEM,Patient Oriented Eczema Measure,mild(n=30)/moderate(n=75)/severe (n=75)), age, and race (White/Black or African American/Other). Symptoms of sleep and psych...
#1Thomas R. HolmesH-Index: 4
#2Xiaoqi WangH-Index: 26
Last. Amy S. PallerH-Index: 36
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#1Rachel Lefferdink (NU: Northwestern University)H-Index: 4
#2Margot Chima (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 5
Last. Amy S. Paller (NU: Northwestern University)H-Index: 36
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