Xue Wu
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyProinflammatory cytokineChemistryApoptosisSuperoxide dismutaseColitisOccludinOxidative stressSteatosisLiver injuryInflammationPogostemonMucositisGlutathione peroxidaseFatty liverAnti-inflammatoryUlcerative colitisOil Red OReactive oxygen speciesGlutathioneGut floraMedicineVery low-density lipoproteinPharmacology
14Publications
6H-index
113Citations
Publications 14
Newest
#1Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Huijuan Luo (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 12 authors...
Non-alcoholic fatty liver disease (NAFLD) has been a leading cause of chronic metabolic disease, seriously posing healthy burdens to the public, whereas interventions available for it are limited to date. Patchouli oil had been reported to attenuate hepatic steatosis in our previous study. β-patchoulene (β-PAE) is a representative component separated from patchouli oil with multiple activities, but its effect against NAFLD is still unknown. To investigate the effect and potential mechanism of β-...
1 CitationsSource
#1Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jia-Zhen Wu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Yu-Cui Li (Guangzhou University of Chinese Medicine)H-Index: 20
view all 12 authors...
Abstract Ulcerative colitis (UC) often occurs accompanied by colonic leakage and flora imbalance, resulting in secondary liver injury (SLI). SLI, in turn, aggravates UC, so the treatment of UC should not ignore it. β-patchoulene (β-PAE), a tricyclic sesquiterpene isolated from Pogostemon cablin, has been reported to exert a protective effect in gastrointestinal disease in our previous studies. However, its protection against UC and SLI remains unknown. Here we explored the protective effect and ...
5 CitationsSource
#1Jia-Zhen Wu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Yuxuan Gan (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 13 authors...
Abstract Intestinal mucositis causes great suffering to cancer patients who undergo chemotherapy and radiotherapy. Owing to the uncertain side effects of anticancer drugs to attenuate patients’ intestinal mucositis, many studies focused on traditional Chinese medicine (TCM). Patchouli alcohol (PA) is an active compound extracted from Pogostemon cablin, and has potent gastrointestinal protective effect. However, whether PA has an effect on intestinal mucositis is still unknown. Therefore, we esta...
11 CitationsSource
#1Yuxuan Gan (Guangzhou University of Chinese Medicine)H-Index: 4
#2Gaoxiang Ai (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiao-Qi Huang (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Ethnopharmacological relevance Pogostemon cablin, commonly named “Guang-Huo-Xiang” in China, has long been renowned for its ability to dispel dampness and regulate gastrointestinal functions. Patchouli oil (P.oil), the major active fraction of Pogostemon cablin, has been traditionally used as the principal component of Chinese medicinal formulae to treat exterior syndrome and diarrhea. However, the effects of P.oil in treating 5-fluorouracil (5-FU)-induced intestinal mucositis have not ...
10 CitationsSource
#1Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Xue Wu (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 14 authors...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized by an accumulation of hepatic lipids. Patchouli oil (PO), which is isolated from the well-known Chinese herb named Pogostemon cablin (Blanco) Benth. (Lamiaceae), inhibits hepatic lipid accumulation effectively. However, its potential ability for the treatment of NAFLD had not been...
3 CitationsSource
#1Minyao Li (Guangzhou University of Chinese Medicine)H-Index: 3
#2Huijuan Luo (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Xue-bao Zheng (Guangzhou University of Chinese Medicine)H-Index: 1
view all 12 authors...
Abstract Objective Huangqin Decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases over thousands of years. We investigated the anti-inflammatory effects of HQD on dextran sulfate sodium (DSS)-induced colitis and underlying mechanisms involved. Methods The experimental mice with 3% DSS were given HQD (2.275g/kg, 4.55g/kg and 9.1g/kg) and Mesalazine (ME, 200 mg/kg) via oral administration for 7 days. The body weight loss, dise...
7 CitationsSource
#1Xue Wu (Guangzhou University of Chinese Medicine)H-Index: 6
#2Nan Xu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 12 authors...
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic hepatic disorder worldwide. The earliest stage of NAFLD is simple steatosis, which is characterized by the accumulation of triglycerides in hepatocytes. Inhibition of steatosis is a potential treatment for NAFLD. Patchouli alcohol (PA) is an active component of Pogostemon cablin (Blanco) Benth. (Labiatae), which is a medicinal food in Asia countries and proved to possess hepatoprotective effect. This research aimed to ...
9 CitationsSource
#1Xue Wu (Guangzhou University of Chinese Medicine)H-Index: 6
#2Qiong-Hui Huang (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 9 authors...
Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Acrostichum aureum Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment ...
10 CitationsSource
#1Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
#2Qiong-Hui Huang (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Jian-Nan Chen (Guangzhou University of Chinese Medicine)H-Index: 19
view all 10 authors...
Acetaminophen (APAP) is commonly used to relieve pain and fever in a clinical setting, but its excessive use can lead to serious hepatotoxicity. Our previous study demonstrated that polydatin (PD) can effectively attenuate D-galactose- and alcohol-induced hepatotoxicity, however, its effect on APAP-induced hepatotoxicity is still unknown. In this study, we explore the protective effect and potential mechanism of PD against APAP-induced hepatotoxicity in mice. The results indicate that PD effecti...
12 CitationsSource
#1Qiong-Hui Huang (Guangzhou University of Chinese Medicine)H-Index: 8
#2Xue Wu (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Yu-Hong Liu (Guangzhou University of Chinese Medicine)H-Index: 19
view all 10 authors...
Correction for ‘Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation’ by Qiong-Hui Huang et al., RSC Adv., 2018, 8, 24399–24410.
10 CitationsSource