Michael Burch
Great Ormond Street Hospital
Internal medicineSurgeryCardiologyRetrospective cohort studyABO blood group systemIntensive care medicineMortality ratePediatricsImmunologyDilated cardiomyopathyExtracorporeal membrane oxygenationHeart failureCardiomyopathyHeart transplantationDiseaseRestrictive cardiomyopathyHeart diseaseImmunosuppressionAngiographyMyocarditisPopulationTransplantationIntensive carePediatric heart transplantationMedicineCohortBiology
161Publications
32H-index
17.7kCitations
Publications 160
Newest
#1Konstantinos Mengrelis (Medical University of Vienna)H-Index: 5
#2Filip Kucera (GOSH: Great Ormond Street Hospital)H-Index: 3
Last. E. Graham Davies (GOSH: Great Ormond Street Hospital)H-Index: 20
view all 12 authors...
Paediatric heart transplantation recipients suffer an increased incidence of infectious, autoimmune and allergic problems. The relative roles of thymus excision and immunosuppressive treatments in contributing to these sequelae are not clear. We compared the immunological phenotypes of 25 heart transplant recipients (Tx), 10 children who underwent thymus excision during non-transplantation cardiac surgery (TE) and 25 age range-matched controls, in two age bands: 1-9 and 10-16 years. Significant ...
Source
#9Victor Tsang (GOSH: Great Ormond Street Hospital)H-Index: 40
Abstract null null Background null : Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible heart transplantation. Here we report the first case series of patients transplanted with ABO-IA, and compare outcomes with those undergoing plasma exchange facilitated ABO-incompatible heart transplantation (ABO-PE). null null null Methods null : Data were retrospectively analysed on all ABO-incompatible heart transplants undertaken at a single centre between 1st J...
Source
#1Marco Romano ('KCL': King's College London)H-Index: 13
#2Monica Sen ('KCL': King's College London)H-Index: 3
Last. Giovanna Lombardi ('KCL': King's College London)H-Index: 81
view all 8 authors...
Regulatory T-cells (Tregs) are a subset of T-cells generated in the thymus with intrinsic immunosuppressive properties. Phase I clinical trials have shown safety and feasibility of Treg infusion to promote immune tolerance and new studies are ongoing to evaluate their efficacy. During heart transplantation, thymic tissue is routinely discarded providing an attractive source of Tregs. In this study, we developed a GMP-compatible protocol for expanding sorted thymus derived CD3+ CD4+ CD25+ CD127- ...
Source
#9Victor Tsang (UCL: University College London)H-Index: 40
Background: Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible heart transplantation. Here we report the first case series of patients transplanted with ABO-IA, and compare outcomes with those undergoing plasma exchange facilitated ABO-incompatible heart transplantation (ABO-PE). Methods: Data were retrospectively analysed on all ABO-incompatible heart transplants undertaken at a single centre between 1st January 2000 and 1st June 2020. Data included a...
#1Craig Laurence (GOSH: Great Ormond Street Hospital)H-Index: 2
#2Michael Burch (GOSH: Great Ormond Street Hospital)H-Index: 32
Abstract Heart failure during childhood is a final common pathway resulting from a range of causes. Diagnosis and management are challenging, and the evidence base for therapy is significantly smaller than in the adult literature. Where evidence is lacking, understanding of the underlying pathology is helpful to determine which treatment strategies are likely to bring most benefit. The clinical and haemodynamic features of heart failure arise from both the initial insult and the subsequent neuro...
Source
#1Marco RomanoH-Index: 13
#2Monica SenH-Index: 3
Last. Giovanna LombardiH-Index: 81
view all 8 authors...
Source
#1Craig Laurence (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 1
#2Mohammad Haini (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 1
Last. Jacob Simmonds (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 2
view all 7 authors...
Source
#1Federica Trucco (UniGe: University of Genoa)H-Index: 11
#2J. Domingos (GOSH: Great Ormond Street Hospital)H-Index: 8
Last. Francesco Muntoni (GOSH: Great Ormond Street Hospital)H-Index: 134
view all 17 authors...
Background Corticosteroids (CSs) have prolonged survival and respiratory function in boys with Duchenne muscular dystrophy (DMD) when compared with CSs-naive boys. Research Question The differential impact of frequently used CSs and their regimens on long-term (> 5 years) cardiorespiratory progression in children with DMD is unknown. Study Design and Methods This was a retrospective longitudinal study including children with DMD followed at Dubowitz Neuromuscular Centre, Great Ormond Street Hosp...
Source
#1Michael Burch (GOSH: Great Ormond Street Hospital)H-Index: 32
#2Amy Taylor (GOSH: Great Ormond Street Hospital)H-Index: 1
Last. Nicholas BannerH-Index: 5
view all 11 authors...
Abstract Objective There are no multi-centre data on the outcomes of transplant for adult congenital heart disease (ACHD) outside of North America. The literature has identified a number of concerns for this population such as increased wait-list and early post-operative mortality. We investigated outcomes in a national cohort to see if these problems are replicated outside of America. Methods Adults (aged ≥16 years) undergoing primary heart transplantation 1995–2014 were identified in the UK Re...
Source
#1Sachin Khambadkone (GOSH: Great Ormond Street Hospital)H-Index: 32
#2Michael Burch (GOSH: Great Ormond Street Hospital)H-Index: 32
Last. Tain-Yen Hsia (GOSH: Great Ormond Street Hospital)H-Index: 28
view all 8 authors...
Abstract We report a patient with congenital heart disease and end stage heart failure after interventions for congenital heart disease resulting in aortic regurgitation that could not be treated with mechanical support to bridge to transplantation. We used Melody valve in aortic position to achieve aortic competence to allow use of a left ventricular assist device to bridge them successfully to cardiac transplantation.
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.