Wei Li
Shenyang Pharmaceutical University
TriterpenoidCytotoxicityInhibitory postsynaptic potentialOrganic chemistryChemistryGlycosidePhytochemicalIn vitroTerpenoidIn vivoSaponinFlavonoidTriterpeneChromatographyTerpeneBiochemistryTraditional medicineBotanyStereochemistryMedicineBiologyPharmacology
257Publications
33H-index
3,738Citations
Publications 239
Newest
#1Zhonghua Luo (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Xude Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Licorice residues are rich in flavonoids and are considered to be valuable reusable resources with broad applications and a high economic value. In view of above, the ultrasound-assisted adsorption/desorption of licorice flavonoids (LFs) on HPD-100 resins was studied. This process was studied at different temperatures (20–30 ℃) using ultrasound at different power densities (0.2, 0.35, 0.5 W/cm2). The higher ultrasonic power density (0.5 W/cm2) and lower temperature (20 ℃) facilitated th...
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#1Jia xin Cheng (CPU: China Pharmaceutical University)H-Index: 1
#2Yu Qi Li (CPU: China Pharmaceutical University)
Last. Jie Zhang (CPU: China Pharmaceutical University)H-Index: 13
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Abstract null null Eleven known phenolic compounds 1–11 were isolated from the MeOH extract of the fruits of Ficus hispida L.f. (Moraceae), all of which have been investigated inhibitory activities of melanin and tyrosinase in vitro. Compounds 1, 2, and 5–8 exhibited potent melanin inhibitory activities against B16F10 melanoma cells, especially 5,7-dihydroxy-4'-methoxy-3'-(3-methyl-2-hydroxybuten-3-yl)isoflavone (2) showed superior inhibitory effect with no or weak toxicities even at the concent...
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#1Xiaojiao Zheng (SPU: Shenyang Pharmaceutical University)
#2Xu Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Jiang Zheng (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Deferiprone (DFP) is a metal chelating agent generally used to treat patients with thalassemia, due to iron overload in clinical settings.Studies have revealed that long-term use of DFP can induce hepatotoxicity, however, mechanisms of its toxic action remain unclear. The present studies are aimed to characterize the reactive metabolite of DFP, to define the metabolic pathway, and to determine the P450 enzymes participating in the bioactivation.A demethylation metabolite (M1) was observed in rat...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Jian Shen (FDA: Food and Drug Administration)H-Index: 9
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Ginger, as a food spice, is widely applied due to its extensive effects. Cedrol (CE) found in ginger is a sesquiterpene with anti-inflammatory activity. The objective of this research is to discuss the efficacy of CE on ameliorating rheumatoid arthritis (RA). CE inhibited chronic inflammation and pain in a dose-dependent manner accompanied by rapid onset and long duration. Besides, CE treatment effectively ameliorated the paw edema volume and arthritis score with no significant effect on body we...
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#1Min Tian (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Shenzhi Zhou (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Jiang Zheng (SPU: Shenyang Pharmaceutical University)H-Index: 7
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1. Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities.2. As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study was conducted to identify reactive metabolite(s), to determine related metabolic pathways, and define the possible association of the bioac...
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#1Lan Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Lihua Xin (SPU: Shenyang Pharmaceutical University)
Last. Jiang Zheng (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Labetalol hydrochloride (LHCl), an α- and β-adrenoreceptor blocker, is widely used for the treatment of hypertension as well as angina pectoris. Previous reports have demonstrated the adverse events during clinical application of LHCl, such as liver injury and acute renal failure. The present study aimed to investigate metabolic activation of LHCl to initiate the elucidation of the mechanisms of its liver toxicity. One glutathione (GSH) conjugate was detected in rat and human primary hepatocytes...
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Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.
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#1Pingping Luo (JNU: Jinan University)H-Index: 1
#2Ming Zheng (JNU: Jinan University)
Last. Jia Xiao (JNU: Jinan University)H-Index: 18
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Abstract Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD in vivo model (the NIAAA model) was used to test the protective functions of SAMC. It was observed that SAMC (300 mg/kg, by gavage method) effectively ameliorated ALD-induced body weight reduction, steatosis, insulin re...
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#2Jin-gang HouH-Index: 11
Last. Wei LiH-Index: 33
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Abstract Ethnopharmacological relevance Diabetic nephropathy (DN) is a major complication of diabetes. The kidney disease develops in nearly 20%–40% of type 2 diabetes (T2D) patients. Ginseng is the root of Panax ginseng C. A. Meyer and has been used in prevention and treatment of diseases for more than 2000 years as a traditional oriental medicine. The 20(R)-ginsenoside Rg3, an active saponin isolated from ginseng, can prevent and treat many diseases. The object of this research was to explore ...
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#1Kouharu Otsuki (Toho University)H-Index: 1
#2Mi Zhang (Toho University)H-Index: 1
Last. Kazuo Koike (Toho University)H-Index: 47
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During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) sh...
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